Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sita J. Lange"'
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56470 (2013)
The CRISPR-Cas (Clustered Regularly Interspaced Short Palindrome Repeats--CRISPR associated proteins) system provides adaptive immunity in archaea and bacteria. A hallmark of CRISPR-Cas is the involvement of short crRNAs that guide associated protein
Externí odkaz:
https://doaj.org/article/d96360b65aad4a368027a1a1afc42190
Autor:
Kundan Sharma, Aris-Edda Stachler, Lisa Nickel, Lisa-Katharina Maier, Christof Lenz, Anita Marchfelder, Lennart Randau, Rolf Backofen, Ruth A. Schmitz, Hagen Richter, Henning Urlaub, Jutta Brendel, Britta Stoll, Thorsten Allers, Sita J. Lange
Publikováno v:
Europe PubMed Central
Journal of Biological Chemistry
The Journal of Biological Chemistry
Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: The Cas6 protein is required for generating crRNAs in CRISPR-Cas I and III systems. Results: The Cas6 protein is necessary for crRNA production but not sufficient for crRNA maintenance in Haloferax. Conclusion: A Cascade-like complex is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98025e8ea2dd817f4cf449d41a29e5a4
https://doi.org/10.1074/jbc.m113.508184
https://doi.org/10.1074/jbc.m113.508184
CRISPRmap: an automated classification of repeat conservation in prokaryotic adaptive immune systems
Publikováno v:
Nucleic Acids Research
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Central to Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Cas systems are repeated RNA sequences that serve as Casprotein–binding templates. Classification is based on the architectural composition of associated Cas proteins, con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4914fb8e2ccdc7aa694aa887fc45981
http://europepmc.org/articles/PMC3783184
http://europepmc.org/articles/PMC3783184
Autor:
Lisa-Katharina Maier, Susan Fischer, Eike Fischer, Jens Wöhnert, Britta Stoll, Elke Duchardt-Ferner, Karina A. Haas, Anita Marchfelder, Sita J. Lange, Rolf Backofen
Publikováno v:
RNA Biology
To fend off foreign genetic elements, prokaryotes have developed several defense systems. The most recently discovered defense system, CRISPR/Cas, is sequence-specific, adaptive and heritable. The two central components of this system are the Cas pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93db7dffa76a96b9563585e6ea35cd73
http://europepmc.org/articles/PMC3737343
http://europepmc.org/articles/PMC3737343
Autor:
Susan Fischer, Rolf Backofen, Jutta Brendel, Lisa-Katharina Maier, Britta Stoll, Anita Marchfelder, Sita J. Lange
Publikováno v:
Biochemical Society transactions. 41(6)
Uptake of foreign mobile genetic elements is often detrimental and can result in cell death. For protection against invasion, prokaryotes have developed several defence mechanisms, which take effect at all stages of infection; an example is the recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b68095a1f5fff093a7d58379d3ba69c
https://pubmed.ncbi.nlm.nih.gov/24256235
https://pubmed.ncbi.nlm.nih.gov/24256235
Autor:
Dominik Jäger, Lisa Nickel, Ruth A. Schmitz, Sita J. Lange, Katrin Weidenbach, Nadja Heidrich, Rolf Backofen
Publikováno v:
RNA biology. 10(5)
The clustered regularly interspaced short palindromic repeats (CRISPR) system represents a highly adaptive and heritable defense system against foreign nucleic acids in bacteria and archaea. We analyzed the two CRISPR-Cas systems in Methanosarcina ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1967b7222cf41695633c8abb0144713e
https://pubmed.ncbi.nlm.nih.gov/23619576
https://pubmed.ncbi.nlm.nih.gov/23619576
The prokaryotic antiviral defense systems CRISP R (clustered regularly interspaced short palindromic repeats)/Cas (CRISP Rassociated) employs short crRNAs (CRISP R RNAs) to target invading viral nucleic acids. A short spacer sequence of these crRNAs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7d1df1865e7dcd43e5ea190a74cb17
https://europepmc.org/articles/PMC3737328/
https://europepmc.org/articles/PMC3737328/
Autor:
Joshua N. Gagnon, Mathias Möhl, Daniel Maticzka, Chris M. Brown, Sita J. Lange, Rolf Backofen
Publikováno v:
Nucleic Acids Research
Determining the structural properties of mRNA is key to understanding vital post-transcriptional processes. As experimental data on mRNA structure are scarce, accurate structure prediction is required to characterize RNA regulatory mechanisms. Althou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ddec56000c8b41e40f5d4a30cd4cee
https://pubmed.ncbi.nlm.nih.gov/22373926
https://pubmed.ncbi.nlm.nih.gov/22373926
Autor:
Timm Oberwahrenbrock, Sita J. Lange, Jan Baumbach, Jörg Ingo Baumbach, Alexander Bunkowski, Sven Rahmann, Nils Kleinbölting
Publikováno v:
Journal of Integrative Bioinformatics, Vol 4, Iss 3, Pp 186-197 (2007)
IMS2 is an Integrated Medical Software system for the analysis of Ion Mobility Spectrometry (IMS) data. It assists medical staff with the following IMS data processing steps: acquisition, visualization, classification, and annotation. IMS2 provides d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2fc3f7dc056ffa1275ff946d68f468
https://doi.org/10.2390/biecoll-jib-2007-75
https://doi.org/10.2390/biecoll-jib-2007-75