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Akademický článek

Ginkgo biloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways

Autor: Congying Wei, Yansong Zhang, Xiaobin Zhong, Sisi Lu, Xiaoqin Zou, Yufang Yang, Songqing Huang, Zhenguang Huang

Publikováno v: Chinese Medicine, Vol 17, Iss 1, Pp 1-14 (2022)

Abstract Background Our previous study indicated that Ginkgo biloba leaf extract (EGb) could protect against cisplatin-induced acute kidney injury in rabbits. The present study aimed to determine the effects and potential molecular mechanisms of EGb

Externí odkaz: https://doaj.org/article/849481ff9c754d5ab3bea799e0367cd3

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Akademický článek

Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice

Autor: Ximiao Chen, Zhengli Li, Haofeng Hong, Ning Wang, Junyi Chen, Sisi Lu, Hongyuan Zhang, Xiaolei Zhang, Chaoyong Bei

Publikováno v: Biomedicine & Pharmacotherapy, Vol 137, Iss , Pp 111238- (2021)

Osteoarthritis (OA), manifested as degeneration and damage of the articular cartilage is a progressive disease of joints. Previous studies have shown that extracellular matrix degradation and inflammation have quite a significant performance in the o

Externí odkaz: https://doaj.org/article/5ff2964957b941ff9c7ffc77be671432

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Construction of Collision Equivalent Scaled Model for Locomotive Using Multi-Parameter Nondimensional Method

Autor: Kaibo Yan, Sisi Lu, Hui Duan, Yang Shu, Shaojiang Dong

Publikováno v: International Journal of Structural Stability and Dynamics.

At present, the research on crashworthiness of locomotive mainly adopts the method of theoretical analysis, numerical simulation and component test, it is too expensive and less repeatable to carry out vehicle crash tests. Therefore, a method to cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f73937d634bafb440d65f086b12f5e6f
https://doi.org/10.1142/s0219455424500159

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Biochanin A protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/HO-1 axis and alleviates pain symptom in intervertebral disc degeneration rats

Autor: Xiangxiang Pan, Sunli Hu, Jinhao Lin, Chanqiong Zhang, Al Mamun Abdullah, Hongyuan Zhang, Zhichen Jiang, Sisi Lu, Jinhui Du, Sunren Sheng, Haiming Jin

Intervertebral disc degeneration (IVDD) is one of the major causes of severe back pain, but reasonable therapies are still lacking due to its complicated pathology. It has been proved that increased level of interleukin-1β (IL-1β) correlates closel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddb93c75949be4a24085eac1f9cd9529
https://doi.org/10.21203/rs.3.rs-1500235/v1

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Drug repurposing of ilepcimide that ameliorates experimental autoimmune encephalomyelitis via restricting inflammatory response and oxidative stress

Autor: Zhaomin, Xu, Sisi, Lu, Xi, Liu, Lu, Tang, Zehui, Liu, Jiayan, Cui, Wanyan, Wang, Weiqiang, Lu, Jin, Huang

Publikováno v: Toxicology and Applied Pharmacology. 458:116328

Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that remains incurable. Herein, we demonstrated that ilepcimide (Antiepilepsirine), an antiepileptic drug used for decades, protects mice from ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3659d57e3152440ee859caf991b8fda6
https://doi.org/10.1016/j.taap.2022.116328

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Discovery of Orally Available Retinoic Acid Receptor-Related Orphan Receptor γ-t/Dihydroorotate Dehydrogenase Dual Inhibitors for the Treatment of Refractory Inflammatory Bowel Disease

Autor: Ji-An Chen, Hui Ma, Zehui Liu, Jinlong Tian, Sisi Lu, Wenqing Fang, Shuyin Ze, Weiqiang Lu, Qiong Xie, Jin Huang, Yonghui Wang

Publikováno v: Journal of medicinal chemistry. 65(1)

Inflammatory bowel disease (IBD) is a multifactorial autoimmune disease, representing a major clinical challenge. Herein, a strategy of dual-targeting approach employing retinoic acid receptor-related orphan receptor γ-t (RORγt) and dihydroorotate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5d40e13866c567293474092614f164
https://pubmed.ncbi.nlm.nih.gov/34957834

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