Tetrandrine targeting SIRT5 exerts anti-melanoma properties via inducing ROS, ER stress, and blocked autophagy

Autor: Yacong Ji, Chongyang Li, Sicheng Wan, Zhen Dong, Chaolong Liu, Leiyang Guo, Shaomin Shi, Mingxin Ci, Minghao Xu, Qian Li, Huanrong Hu, Hongjuan Cui, Yaling Liu

Publikováno v: Journal of Pharmaceutical Analysis, Vol 14, Iss 10, Pp 101036- (2024)

Tetrandrine (TET), a natural bisbenzyl isoquinoline alkaloid extracted from Stephania tetrandra S. Moore, has diverse pharmacological effects. However, its effects on melanoma remain unclear. Cellular proliferation assays, multi-omics analyses, and x

Externí odkaz: https://doaj.org/article/0df8afc14cc54d81bde2af4f87a5bf68

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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.

Autor: Bhatt DP; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA., Mills CA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Anderson KA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, North Carolina, USA; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Henriques BJ; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Lucas TG; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Francisco S; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Liu J; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Ilkayeva OR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA., Adams AE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Kulkarni SR; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA., Backos DS; Computational Chemistry and Biology Core Facility, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA., Major MB; Department of Cell Biology and Physiology, Washington University in St. Louis, St. Louis, Missouri, USA., Grimsrud PA; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA., Gomes CM; Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal; Departmento de Química e Bioquimica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal., Hirschey MD; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, North Carolina, USA; Sarah W. Stedman Nutrition and Metabolism Center, Duke University School of Medicine, Durham, North Carolina, USA; Departments of Medicine and Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA; Department of Medicine, Division of Endocrinology, Metabolism, and Nutrition, Duke University School of Medicine, Durham, North Carolina, USA. Electronic address: matthew.hirschey@duke.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Apr; Vol. 298 (4), pp. 101723. Date of Electronic Publication: 2022 Feb 12.