Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Sirt1, sirtuin 1"'
Autor:
Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)
Metabolic homeostasis requires dynamic catabolic and anabolic processes. Autophagy, an intracellular lysosomal degradative pathway, can rewire cellular metabolism linking catabolic to anabolic processes and thus sustain homeostasis. This is especiall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58c0ac6db641c550d04c5a5c6ba5a1a
https://doi.org/10.1016/j.apsb.2021.07.021
https://doi.org/10.1016/j.apsb.2021.07.021
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2749-2767 (2021)
Diabetic nephropathy (DN) has been recognized as a severe complication of diabetes mellitus and a dominant pathogeny of end-stage kidney disease, which causes serious health problems and great financial burden to human society worldwide. Conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d8ab4193adc39b242fa3c089b4f517
https://doi.org/10.1016/j.apsb.2020.12.020
https://doi.org/10.1016/j.apsb.2020.12.020
Publikováno v:
Journal of Traditional and Complementary Medicine, Vol 10, Iss 5, Pp 434-439 (2020)
Journal of Traditional and Complementary Medicine
Journal of Traditional and Complementary Medicine
In recent times, many scientists have given great attention to nutraceuticals (complementary medicine) as it widely used for promoting health status. In particular for the prevention and treatment of various neurological diseases or disorders without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0f0bc227bf2031dfbc2afc233615df
http://www.sciencedirect.com/science/article/pii/S2225411020301425
http://www.sciencedirect.com/science/article/pii/S2225411020301425
Autor:
Wen Li, Hiroshi Kurihara, Chang Yan, Zhuo Luo, Rong-Rong He, Yi-Fang Li, Robert Dallmann, Xue Li
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)
Acta Pharmaceutica Sinica B, Vol 10, Iss 3, Pp 383-398 (2020)
Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, is able to establish a lifelong latent infection in the human host. Following primary replication in mucosal epithelial cells, the virus can enter sensory neurons innervating peripheral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e8bd4a9163466778ab2c0a48ebad5d
https://doi.org/10.1016/j.apsb.2019.06.005
https://doi.org/10.1016/j.apsb.2019.06.005
Publikováno v:
Journal of Ginseng Research, Vol 44, Iss 2, Pp 179-193 (2020)
Journal of Ginseng Research
Journal of Ginseng Research
Ginseng products on the market show high variability in their composition and overall quality. This becomes a challenge for both consumers and health-care professionals who are in search of high-quality, reliable ginseng products that have a proven s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d9700de3065929919bceba8f514e74
http://www.sciencedirect.com/science/article/pii/S1226845319300090
http://www.sciencedirect.com/science/article/pii/S1226845319300090
Publikováno v:
Pharmacology & Therapeutics
The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has prompted scientists to address an urgent need for defining mechanisms of disease pathology and treatment. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9934ef0c6702914904ddd32cd943ffca
Autor:
Vera Maria Morsch, Karine Paula Reichert, Milagros Fanny Vera Castro, Naiara Stefanello, Vanessa Valéria Miron, Andréia Machado Cardoso, Maria Rosa Chitolina Schetinger, Charles Elias Assmann, Nathieli B. Bottari
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 137, Iss, Pp 111273-(2021)
Biomedicine & Pharmacotherapy
Biomedicine & Pharmacotherapy
Graphical abstract
Highlights • The coexistence of diabetes and hypertension represents a major risk factor for the onset of cardiovascular problems. • The purinergic signaling pathway constitutes a ubiquitous system of cell–cell communica
Highlights • The coexistence of diabetes and hypertension represents a major risk factor for the onset of cardiovascular problems. • The purinergic signaling pathway constitutes a ubiquitous system of cell–cell communica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34db00a41121e428fb7b9d4795d39e99
http://www.sciencedirect.com/science/article/pii/S0753332221000585
http://www.sciencedirect.com/science/article/pii/S0753332221000585
Autor:
Manuela Viola, Davide Vigetti, Paola Moretto, Evgenia Karousou, Alberto Passi, Ilaria Caon, Arianna Parnigoni
Publikováno v:
Matrix Biology Plus
Matrix Biology Plus, Vol 11, Iss, Pp 100060-(2021)
Matrix Biology Plus, Vol 11, Iss, Pp 100060-(2021)
In the extracellular matrix (ECM), the glycosaminoglycan (GAG) hyaluronan (HA) has different physiological roles favouring hydration, elasticity and cell survival. Three different isoforms of HA synthases (HAS1, 2, and 3) are responsible for the prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b11cc44a8141b5c204d5fea01a8913
http://europepmc.org/articles/PMC8377009
http://europepmc.org/articles/PMC8377009
Autor:
Bhushan Thakur, Kazuho Ishine, Noriaki Shimizu, Mirit I. Aladjem, Ryonosuke Taniguchi, Koichi Utani
Publikováno v:
The Journal of Biological Chemistry
Sirtuin 1 (SIRT1) is a protein deacetylase that maintains genome stability by preventing the activation of latent replication origins. Amplified genes in cancer cells localize on either extrachromosomal double minutes (DMs) or the chromosomal homogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697d87c6d27734a17d75a753638578c9
https://pubmed.ncbi.nlm.nih.gov/33539925
https://pubmed.ncbi.nlm.nih.gov/33539925
Autor:
David G. Le Couteur, Sun Woo Sophie Kang, Glen P Lockwood, Nicholas J. Hunt, Victoria C. Cogger
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1151-1161 (2019)
While the liver demonstrates remarkable resilience during aging, there is growing evidence that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and systemic disease. The aging process in the liver is driven by alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf961c6cce83782d5f12524960f4f45
https://doi.org/10.1016/j.csbj.2019.07.021
https://doi.org/10.1016/j.csbj.2019.07.021