Zobrazeno 1 - 10
of 20 199
pro vyhledávání: '"Sirt1"'
Autor:
Lang Deng, Weixi Xie, Miao Lin, Dayan Xiong, Lei Huang, Xiaohua Zhang, Rui Qian, Xiaoting Huang, Siyuan Tang, Wei Liu
Publikováno v:
Chinese Medicine, Vol 19, Iss 1, Pp 1-19 (2024)
Abstract Background Acute lung injury (ALI) is the most lethal disease associated with sepsis, and there is a lack of effective drug treatment. As the major cells of sepsis-induced ALI, macrophages polarize toward the proinflammatory M1 phenotype and
Externí odkaz:
https://doaj.org/article/58bb519a3d9a4efb89423fdd1c4c23f6
Autor:
Qian Zhao, Guo-yu Zhou, Qiang Niu, Jing-wen Chen, Pei Li, Zhi-yuan Tian, Dong-jie Li, Tao Xia, Shun Zhang, Ai-guo Wang
Publikováno v:
Journal of Advanced Research, Vol 65, Iss , Pp 197-210 (2024)
Introduction: Neurological dysfunction induced by fluoride contamination is still one of major concern worldwide. Recently, neuroprotective roles of silent information regulator 1 (SIRT1) focusing on mitochondrial function have been highlighted. Howe
Externí odkaz:
https://doaj.org/article/691df34dbc7240ad9cb8d404f20530a5
Publikováno v:
Research in Pharmaceutical Sciences, Vol 19, Iss 5, Pp 622-633 (2024)
Background and purpose: Renal injury is a serious disorder that can be caused by some diseases or agents. Rosmarinic acid (RA) is a natural and safe compound with powerful antioxidant and anti-inflammatory properties. In this study, the ameliorative
Externí odkaz:
https://doaj.org/article/198b0d3a34154a11b251377b5adf17a2
Publikováno v:
Egyptian Journal of Medical Human Genetics, Vol 25, Iss 1, Pp 1-10 (2024)
Abstract Background Premature myocardial infarction (PMI) is one of the most pressing global issues in modern cardiology. Recently, the incidence of PMI has gradually increased. Researches found that genetics is a major contributor in its development
Externí odkaz:
https://doaj.org/article/963b18593f5640e397977ead881d3c03
Autor:
Maysa A. Mobasher, Marwa A. Shabana, Mousa O. Germoush, Najlaa Yousef Abuzinadah, Amir Abd-elhameed, Shereen A. Baioumy, Moataz A. ElKot, Marwa M. Esawy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Long-term, uncontrolled diabetes mellitus can lead to micro- and macrovascular problems. The protective function of lncRNA LYPLAL1 is to reduce endothelium cell inflammation by upregulating sirtuin 1 (SIRT1) and reducing microRNA (miR)-204-5
Externí odkaz:
https://doaj.org/article/05bb917edb1d492bbb7620ab1e7e82bc
Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 20, Pp 1919-1929 (2024)
Ya Gao,1 Shuyue Li,1 Jian Zhang,1 Yidan Zhang,1 Yuan Zhao,1 Shuming Zhang,2 Lujie Zuo,3 Guofeng Yang1 1Department of Geriatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, People’s Republic of China; 2Department o
Externí odkaz:
https://doaj.org/article/3126bbd380854cedb535e33f0b4f4817
Autor:
Yufei Zhang, Juxiong Liu, Shuai Yuan, Shu Liu, Meng Zhang, Huijie Hu, Yu Cao, Guiqiu Hu, Shoupeng Fu, Wenjin Guo
Publikováno v:
Journal of Dairy Science, Vol 107, Iss 10, Pp 8722-8735 (2024)
ABSTRACT: High-yield dairy cows typically undergo intense cellular metabolism, leading to oxidative stress in their mammary tissues. Our study found that compared with ordinary cows, these high-yield cows had significantly elevated levels of H2O2, li
Externí odkaz:
https://doaj.org/article/4d4659e45b4041a3bcafe038364b1e03
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background The increasing incidence of diabetes mellitus has established diabetic cataracts (DC) as a significant worldwide public health issue. The mechanisms underlying DC remain unknown, and effective prevention and treatment strategies a
Externí odkaz:
https://doaj.org/article/44abc2921c7e44cb86e9859eea78c7c6
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9895-9905 (2024)
The vascular endothelium is the first line of defense to prevent cardiovascular disease. Its optimal functioning and health are maintained by the interaction of the proteins—endothelial nitric oxide synthase (eNOS), sirtuin 1 (SIRT1), and endotheli
Externí odkaz:
https://doaj.org/article/82f943a2122c4ac790c377b8408d4b8c