Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sirpa Laakso"'
Autor:
Anne Juppo, Sirpa Laakso, Piritta Koistinen, DS Samiulla, Anna Shevchenko, Chira Malmström, Bert van Veen, Krista Ojala, Jukka Salmia, Timo Korjamo, Indu Bansal, Johanna Ylikotila
Publikováno v:
International journal of pharmaceutics. 606
Our objectives were to stabilize a non-clinical suspension for use in toxicological studies and to develop methods to investigate the stability of the formulation in terms of salt disproportionation. The compound under research was a hydrochloride sa
Publikováno v:
Bioanalysis. 2:1185-1194
The relationship between the exposure to drug metabolites and overall drug safety has become an integral part of the drug-development process. In-depth discussions in the scientific community, as well as recent guidelines on Drug Safety Testing of Me
Autor:
Carl Johan Sennbro, Sirpa Laakso, Dietmar Schmidt, Josep Maria Jansat, Achim Freisleben, Hans Mulder, Marcel de Zwart, Pierre Boulanger, Michael P. Andersen, Elizabeth Thomas, Stephanie Fischmann, Nathalie Mokrzycki-Issartel, Dirk Kasel, Morten A. Kall, Philip Timmerman, Richard Hucker, Fernando Romero, Stephen White, Berthold Lausecker, Susanne Globig, Silke Luedtke, Ben Gordon, Norbert Knebel, Peter van Amsterdam, Magnus Knutsson, Richard Abbott, Margarete Brudny-Kloeppel
Publikováno v:
Bioanalysis. 1:1049-1056
Following intensive discussions, review, alignment of procedures and multiple surveys among their member companies, the European Bioanalysis Forum (EBF) is providing a recommendation on how to integrate incurred sample reproducibility (ISR) in the bi
Autor:
Martti Marvola, Pirjo Kortesuo, Minna Kangas, Tiina Leino, Lauri Vuorilehto, Mika Jokinen, Antti Yli-Urpo, Sirpa Laakso, Juha Kiesvaara, Manja Ahola
Publikováno v:
Biomaterials. 23:2795-2801
The objective of this study was to evaluate the possibilities to control the release rate of dexmedetomidine (DMED) from different spray-dried silica gel microparticle formulations. Microparticles were prepared by spray drying a silica sol polymer so
Autor:
Lieve Dillen, Brigitte Buscher, Klaus Pusecker, Philip Timmerman, Winfried Wagner-Redeker, Thomas Pfeifer, Pascal Delrat, Sirpa Laakso, Hermann Mascher, Mira Doig
Publikováno v:
Bioanalysis. 6(5)
Plasma protein binding (PPB) is an important parameter for a drug’s efficacy and safety that needs to be investigated during each drug-development program. Even though regulatory guidance exists to study the extent of PPB before initiating clinical
Autor:
Lauri Vuorilehto, Pirjo Kortesuo, Tiina Leino, Manja Ahola, Martti Marvola, Minna Kangas, Juha Kiesvaara, Antti Yli-Urpo, Sirpa Laakso
Publikováno v:
Journal of Controlled Release. 76:227-238
The effect of alkyl substitution of the silica xerogel matrix on the release rate of dexmedetomidine was evaluated. Silica sol was processed by either casting or spray drying. When the reaction precursor tetraethylorthosilicate (TEOS) was partially s
Publikováno v:
Clinical pharmacology and therapeutics. 57(6)
Objectives The pharmacokinetics of toremifene was investigated in an open study with four parallel groups of 10 subjects each. Subjects with impaired liver function (biopsy-proven liver disease), activated liver function (drug-induced), and impaired
Publikováno v:
Journal of chromatography. 526(2)
A high-performance liquid chromatographic method for the determination of plasma concentrations of erythromycin base and 2'-acetylerythromycin, an ester prodrug of erythromycin, is described. tert.-Butyl methyl ether extracts of 1-ml plasma samples (