Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Siroon, Bekkering"'
Autor:
Julia van Tuijl, Julia I.P. van Heck, Harsh Bahrar, Wieteke Broeders, Johan Wijma, Yvonne M. ten Have, Martin Giera, Heidi Zweers-van Essen, Laura Rodwell, Leo A.B. Joosten, Mihai G. Netea, Lydia A. Afman, Siroon Bekkering, Niels P. Riksen
Publikováno v:
iScience, Vol 27, Iss 11, Pp 111103- (2024)
Summary: Brief exposure of monocytes to atherogenic molecules, such as oxidized lipoproteins, triggers a persistent pro-inflammatory phenotype, named trained immunity. In mice, transient high-fat diet leads to trained immunity, which aggravates ather
Externí odkaz:
https://doaj.org/article/2cbb666c2b6342b7a4a95757c35a8009
Autor:
Siroon Bekkering, Christoph Saner, Boris Novakovic, Toby Mansell, Danielle K. Longmore, Zoe McCallum, Anne-Louise Ponsonby, Markus Juonala, Mihai G. Netea, Matthew A. Sabin, Richard Saffery, Niels P. Riksen, David P. Burgner
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109762- (2024)
Summary: Cardiometabolic risk accrues across the life course and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but pediatric data are scarce. In a cross-sectional and longitudin
Externí odkaz:
https://doaj.org/article/18ea2a93c6124c2c9822b1d8f3285792
Autor:
Jan‐Quinten Mol, Julia van Tuijl, Siroon Bekkering, Laura Rodwell, Gheorghe A. M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 8 (2024)
Externí odkaz:
https://doaj.org/article/1a40ee6e9b894a50824cece00ad022d8
Autor:
Mihaela I. Dregoesc, Helin Tercan, Adrian B. Țigu, Siroon Bekkering, Leo AB. Joosten, Mihai G. Netea, Rosanne C. van Deuren, Alexander Hoischen, Niels P. Riksen, Adrian C. Iancu
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109472- (2024)
Summary: Clonal hematopoiesis (CH) is a risk factor for atherosclerotic cardiovascular disease, but the impact of smaller clones and the effect on inflammatory parameters is largely unknown. Using ultrasensitive single-molecule molecular inversion pr
Externí odkaz:
https://doaj.org/article/f86bcc0f47134c969cae7c331a450621
Autor:
Helin Tercan, Benjamin C. Cossins, Rosanne C. van Deuren, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Alexander Hoischen, Siroon Bekkering, Niels P. Riksen
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 2 (2024)
Background Obesity is accompanied by dysregulated inflammation, which can contribute to vasculometabolic complications including metabolic syndrome and atherosclerosis. Recently, clonal hematopoiesis of indeterminate potential (CHIP) has emerged as a
Externí odkaz:
https://doaj.org/article/386a3cf3b948494e8e35866013b4781d
Autor:
Jan-Quinten Mol, Julia van Tuijl, Siroon Bekkering, Charlotte D.C.C. van der Heijden, Sander A.J. Damen, Benjamin C. Cossins, Liesbeth van Emst, Tim M. Nielen, Laura Rodwell, Yang Li, Gheorghe A.M. Pop, Mihai G. Netea, Niels van Royen, Niels P. Riksen, Saloua El Messaoudi
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107183- (2023)
Summary: An increasing number of patients develop an atherothrombotic myocardial infarction (MI) in the absence of standard modifiable risk factors (SMuRFs). Monocytes and macrophages regulate the development of atherosclerosis, and monocytes can ado
Externí odkaz:
https://doaj.org/article/fc49a727a85442d1b19e4779f98bee00
Autor:
Erika Huijser, Cornelia G. van Helden-Meeuwsen, Dwin G. B. Grashof, Jessica R. Tarn, Zana Brkic, Josje M. A. Huisman, M. Javad Wahadat, Harmen J. G. van de Werken, Ana P. Lopes, Joel A. G. van Roon, Paul L. A. van Daele, Sylvia Kamphuis, Wan-Fai Ng, Siroon Bekkering, Leo A. B. Joosten, Willem A. Dik, Marjan A. Versnel
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundTrained immunity – or innate immune memory – can be described as the long-term reprogramming of innate immune cells towards a hyperresponsive state which involves intracellular metabolic changes. Trained immunity has been linked to athe
Externí odkaz:
https://doaj.org/article/72f7b5e73ccf4457a9a39a2512306f2e
Autor:
Toby Mansell, Richard Saffery, Satvika Burugupalli, Anne-Louise Ponsonby, Mimi LK Tang, Martin O'Hely, Siroon Bekkering, Adam Alexander T Smith, Rebecca Rowland, Sarath Ranganathan, Peter D Sly, Peter Vuillermin, Fiona Collier, Peter Meikle, David Burgner, Barwon Infant Study Investigator Group
Publikováno v:
eLife, Vol 11 (2022)
Background: The risk of adult onset cardiovascular and metabolic (cardiometabolic) disease accrues from early life. Infection is ubiquitous in infancy and induces inflammation, a key cardiometabolic risk factor, but the relationship between infection
Externí odkaz:
https://doaj.org/article/3717633ff6504fb99ff75255c72b0e3a
Autor:
Fiona Collier, Cerys Chau, Toby Mansell, Keshav Faye-Chauhan, Peter Vuillermin, Anne-Louise Ponsonby, Richard Saffery, Mimi L. K. Tang, Martin O’Hely, John Carlin, Lawrence E. K. Gray, Siroon Bekkering, David Burgner, the Barwon Infant Study Investigator Group
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Early childhood is characterised by repeated infectious exposures that result in inflammatory responses by the innate immune system. In addition, this inflammatory response to infection is thought to contribute to the epidemiological evidence linking
Externí odkaz:
https://doaj.org/article/3c7bd062a3004bbeadf0a51f347173e8
Autor:
Mihaela Ioana Dregoesc, Adrian Bogdan Ţigu, Siroon Bekkering, Charlotte D. C. C. van der Heijden, Sorana Daniela Bolboacǎ, Leo A. B. Joosten, Frank L. J. Visseren, Mihai G. Netea, Niels P. Riksen, Adrian Corneliu Iancu
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectiveDespite the advances in the control of traditional risk factors, coronary artery disease (CAD) remains the greatest cause of morbidity and mortality. Our aim was to establish the relation between plasma proteomics analysis and the risk of ca
Externí odkaz:
https://doaj.org/article/4d767bf4e5124724861b43a9f5bb950f