FMRP gains mitochondrial fission control.

Autor: Sirois CL; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA., Sandoval SO; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA., Zhao X; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA. xinyu.zhao@wisc.edu.; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. xinyu.zhao@wisc.edu.

Publikováno v: Nature cell biology [Nat Cell Biol] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.

Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.

Autor: Sandoval SO; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA., Cappuccio G; Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Kruth K; Department of Psychiatry, University of Iowa Health Care, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA 52242, USA., Osenberg S; Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Khalil SM; Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA., Méndez-Albelo NM; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA., Padmanabhan K; Department of Neuroscience, Center for Visual Science, Del Monte Institute for Neuroscience, University of Rochester School of Medicine and Dentistry, Rochester NY 14642, USA., Wang D; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Departments of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI 53705, USA., Niciu MJ; Department of Psychiatry, University of Iowa Health Care, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA 52242, USA., Bhattacharyya A; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Stein JL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Sousa AMM; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Waxman EA; Center for Cellular and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Center for Epilepsy and NeuroDevelopmental Disorders (ENDD), The Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Buttermore ED; Human Neuron Core, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA; F.M. Kirby Neurobiology Department, Boston Children's Hospital, Boston, MA, USA., Whye D; Human Neuron Core, Rosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA; F.M. Kirby Neurobiology Department, Boston Children's Hospital, Boston, MA, USA., Sirois CL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Williams A; Department of Psychiatry, University of Iowa Health Care, Iowa City, IA 52242, USA; Iowa Neuroscience Institute, University of Iowa Health Care, Iowa City, IA 52242, USA. Electronic address: aislinn-williams@uiowa.edu., Maletic-Savatic M; Department of Pediatrics-Neurology, Baylor College of Medicine, Houston, TX, USA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA; Center for Drug Discovery, Baylor College of Medicine, Houston, TX, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA. Electronic address: mirjana.maletic-savatic@bcm.edu., Zhao X; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: xinyu.zhao@wisc.edu.

Publikováno v: Stem cell reports [Stem Cell Reports] 2024 Jun 11; Vol. 19 (6), pp. 796-816. Date of Electronic Publication: 2024 May 16.

Species-specific FMRP regulation of RACK1 is critical for prenatal cortical development.

Autor: Shen M; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Sirois CL; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Guo Y; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Li M; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Dong Q; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA., Méndez-Albelo NM; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Molecular Cellular Pharmacology Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA., Gao Y; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Khullar S; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Departments of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Kissel L; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA., Sandoval SO; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI 53705, USA., Wolkoff NE; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Huang SX; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Xu Z; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Graduate Program in Cell and Molecular Biology, University of Wisconsin-Madison, Madison, WI 53705, USA., Bryan JE; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Departments of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Contractor AM; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Korabelnikov T; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Glass IA; Birth Defects Research Laboratory, University of Washington, Seattle, WA 98195, USA., Doherty D; Birth Defects Research Laboratory, University of Washington, Seattle, WA 98195, USA., Levine JE; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA., Sousa AMM; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Chang Q; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neurology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA., Bhattacharyya A; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Cell and Regenerative Biology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Wang D; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Departments of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA., Werling DM; Laboratory of Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA., Zhao X; Waisman Center, University of Wisconsin-Madison, Madison, WI 53705, USA; Department of Neuroscience, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53705, USA. Electronic address: xinyu.zhao@wisc.edu.

Publikováno v: Neuron [Neuron] 2023 Dec 20; Vol. 111 (24), pp. 3988-4005.e11. Date of Electronic Publication: 2023 Oct 10.

BOMA, a machine-learning framework for comparative gene expression analysis across brains and organoids.

Autor: He C; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Kalafut NC; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, USA., Sandoval SO; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA., Risgaard R; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA., Sirois CL; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA., Yang C; Department of Mathematics, University of Wisconsin-Madison, Madison, WI, USA., Khullar S; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Suzuki M; Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, USA., Huang X; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA., Chang Q; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Departments of Medical Genetics and Neurology, University of Wisconsin-Madison, Madison, WI, USA., Zhao X; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA., Sousa AMM; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, USA., Wang D; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.; Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.; Department of Computer Sciences, University of Wisconsin-Madison, Madison, WI, USA.

Publikováno v: Cell reports methods [Cell Rep Methods] 2023 Feb 15; Vol. 3 (2), pp. 100409. Date of Electronic Publication: 2023 Feb 15 (Print Publication: 2023).

Identification of Small-Molecule Activators of the Ubiquitin Ligase E6AP/UBE3A and Angelman Syndrome-Derived E6AP/UBE3A Variants.

Autor: Offensperger F; Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Müller F; Department of Biology, University of Konstanz, Konstanz, Germany., Jansen J; Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Hammler D; Department of Chemistry, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Götz KH; Department of Chemistry, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Marx A; Department of Chemistry, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Sirois CL; Department of Genetics and Genome Sciences, UConn Health, University of Connecticut, Farmington, CT, USA., Chamberlain SJ; Department of Genetics and Genome Sciences, UConn Health, University of Connecticut, Farmington, CT, USA., Stengel F; Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany., Scheffner M; Department of Biology, University of Konstanz, Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Konstanz, Germany. Electronic address: martin.scheffner@uni-konstanz.de.

Publikováno v: Cell chemical biology [Cell Chem Biol] 2020 Dec 17; Vol. 27 (12), pp. 1510-1520.e6. Date of Electronic Publication: 2020 Sep 22.