Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Sirlester A. Parker"'
Autor:
Jeffrey R. Peterson, Ulrike Rennefahrt, Stefan Knapp, Sirlester A. Parker, Benjamin E. Turk, Sean Deacon, Jonathan Chernoff, Karthik Devarajan, Alexander Beeser
The p21-activated kinases (Paks) serve as effectors of the Rho family GTPases Rac and Cdc42. The six human Paks are divided into two groups based on sequence similarity. Group I Paks (Pak1 to -3) phosphorylate a number of substrates linking this grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51e6ceaae3e3d537b65cb75eb9ce23b
https://ora.ox.ac.uk/objects/uuid:9c75ecff-7d63-46c1-9502-3c6d4a039d01
https://ora.ox.ac.uk/objects/uuid:9c75ecff-7d63-46c1-9502-3c6d4a039d01
Autor:
Masoud Vedadi, Matthieu Schapira, Debra A. Thompson, Sirlester A. Parker, Sirano Dhe-Paganon, P.J. Finerty, Xudong Huang, Benjamin E. Turk, Christine Butler-Cole, John R. Walker
Publikováno v:
Journal of Structural Biology
The mammalian ortholog of the retroviral oncogene v-Eyk, and a receptor tyrosine kinase upstream of antiapoptotic and transforming signals, Mer (MerTK) is a mediator of the phagocytic process, being involved in retinal and immune cell clearance and p
Autor:
Frank H. Niesen, Laurence H. Pearl, Sirlester A. Parker, Antony W. Oliver, Benjamin E. Turk, Ashley C. W. Pike, Stefan Knapp, P. Rellos, Andrew P. Turnbull
Publikováno v:
The EMBO Journal
Protein kinase autophosphorylation of activation segment residues is a common regulatory mechanism in phosphorylation-dependent signalling cascades. However, the molecular mechanisms that guarantee specific and efficient phosphorylation of these site
Autor:
Frank Sobott, Sirlester A. Parker, Benjamin E. Turk, Jeyanthy Eswaran, Judit É. Debreczeni, Antonio Bernad, Stefan Knapp, Rafael Najmanovich, Jose Manuel Ligos, Bárbara Guinea
Publikováno v:
Structure(London, England:1993)
The activation segment of protein kinases is structurally highly conserved and central to regulation of kinase activation. Here we report an atypical activation segment architecture in human MPSK1 comprising a beta sheet and a large alpha-helical ins
Autor:
Stefan Knapp, Eidarus Salah, Panagis Filippakopoulos, Benjamin E. Turk, Gabor Bunkoczi, Wang Min, Frank Sobott, Haifeng Zhang, Sirlester A. Parker, Susanne Müller, Oleg Fedorov
Publikováno v:
Structure(London, England:1993)
Apoptosis signal-regulating kinase 1 (ASK1) plays an essential role in stress and immune response and has been linked to the development of several diseases. Here, we present the structure of the human ASK1 catalytic domain in complex with staurospor
Autor:
Thomas W. Sturgill, Sirlester A. Parker, Jeffrey Shabanowitz, Katherine A. Larson, Konstantin Galaktionov, Philipp Kaldis, Zheng Fu, Raghu K. Chitta, Benjamin E. Turk, Steven M. Cohn, Matthew W. Lawrence, Donald F. Hunt
Publikováno v:
Molecular and Cellular Biology. 26:8639-8654
MAK (male germ cell-associated protein kinase) and MRK/ICK (MAK-related kinase/intestinal cell kinase) are human homologs of Ime2p in Saccharomyces cerevisiae and of Mde3 and Pit1 in Schizosaccharomyces pombe and are similar to human cyclin-dependent
Autor:
Grace R. Jeschke, Matthew C. Good, Xiuqiong Zhou, Nancy M. Hollingsworth, Bruce Stillman, Wendell A. Lim, David F. Stern, Philip M. Kim, Richelle Sopko, Miri Jwa, Brenda J. Andrews, Mark Gerstein, Janine Mok, Stacy Piccirillo, Attila Remenyi, Ved Desai, Michael Snyder, Hugo Y. K. Lam, Sirlester A. Parker, Hengyao Niu, Holly E. Sassi, Clarence S.M. Chan, Benjamin E. Turk, Elisabetta Cameroni, Yi-Jun Sheu, Jia Lin Nianhan Ma, Claudio De Virgilio, Douglas L. Sheridan
Phosphorylation is a universal mechanism for regulating cell behavior in eukaryotes. Although protein kinases target short linear sequence motifs on their substrates, the rules for kinase substrate recognition are not completely understood. We used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8687e86b66c571a7fd1182e9885281
http://doc.rero.ch/record/17524/files/vir_dpk_sm.pdf
http://doc.rero.ch/record/17524/files/vir_dpk_sm.pdf
Autor:
Sirano Dhe-Paganon, Sirlester A. Parker, John R. Walker, Tara L. Davis, Abdellah Allali-Hassani, Benjamin E. Turk
Publikováno v:
The FEBS journal. 276(16)
Ephrin receptor tyrosine kinase A3 (EphA3, EC 2.7.10.1) is a member of a unique branch of the kinome in which downstream signaling occurs in both ligand- and receptor-expressing cells. Consequently, the ephrins and ephrin receptor tyrosine kinases of
Publikováno v:
The Journal of biological chemistry. 283(28)
Mitogen-activated protein kinases (MAPKs) mediate cellular responses to a wide variety of extracellular stimuli. MAPK signal transduction cascades are tightly regulated, and individual MAPKs display exquisite specificity in recognition of their targe
Autor:
Rune Linding, Martin L. Miller, Stefan Knapp, Marina Olhovsky, Francesca Diella, Benjamin E. Turk, Sirlester A. Parker, Gianni Cesareni, Jennifer Bordeaux, Nikolaj Blom, Søren Brunak, Shawn S.-C. Li, Lars Juhl Jensen, Tony Pawson, Lei Li, Claus Jørgensen, Michael B. Yaffe, Peer Bork, Adrian Pasculescu, Marilyn Hsiung, Michele Tinti, Jes Alexander, Thomas Sicheritz-Pontén
Publikováno v:
Science signaling. 1(35)
Systematic and quantitative analysis of protein phosphorylation is revealing dynamic regulatory networks underlying cellular responses to environmental cues. However, matching these sites to the kinases that phosphorylate them and the phosphorylation