Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Sirle Saul"'
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Yiran E. Liu, Sirle Saul, Aditya Manohar Rao, Makeda Lucretia Robinson, Olga Lucia Agudelo Rojas, Ana Maria Sanz, Michelle Verghese, Daniel Solis, Mamdouh Sibai, Chun Hong Huang, Malaya Kumar Sahoo, Rosa Margarita Gelvez, Nathalia Bueno, Maria Isabel Estupiñan Cardenas, Luis Angel Villar Centeno, Elsa Marina Rojas Garrido, Fernando Rosso, Michele Donato, Benjamin A. Pinsky, Shirit Einav, Purvesh Khatri
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Each year 3–6 million people develop life-threatening severe dengue (SD). Clinical warning signs for SD manifest late in the disease course and are nonspecific, leading to missed cases and excess hospital burden. Better SD progn
Externí odkaz:
https://doaj.org/article/793e01a463394919ad34b1afb12b340e
Autor:
Belén Martinez-Gualda, Mirthe Graus, Anita Camps, Emiel Vanhulle, Sirle Saul, Siavash Azari, Do Hoang Nhu Tran, Laura Vangeel, Winston Chiu, Johan Neyts, Dominique Schols, Shirit Einav, Kurt Vermeire, Steven De Jonghe
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
RNA viral infections, including those caused by respiratory syncytial virus (RSV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and Venezuelan Equine encephalitis virus (VEEV), pose a major global health challenge. Here, we report th
Externí odkaz:
https://doaj.org/article/b71621893a6241afbd7e65cfc4b5b2f3
Autor:
Zhiyuan Yao, Fabio Zanini, Sathish Kumar, Marwah Karim, Sirle Saul, Nishank Bhalla, Nuttada Panpradist, Avery Muniz, Aarthi Narayanan, Stephen R Quake, Shirit Einav
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009306 (2021)
Venezuelan Equine Encephalitis Virus (VEEV) is a major biothreat agent that naturally causes outbreaks in humans and horses particularly in tropical areas of the western hemisphere, for which no antiviral therapy is currently available. The host resp
Externí odkaz:
https://doaj.org/article/f3c4a642ed5140daa770391f39a136c3
Publikováno v:
Molecules, Vol 26, Iss 23, p 7338 (2021)
Emerging viral infections, including those caused by dengue virus (DENV) and Venezuelan Equine Encephalitis virus (VEEV), pose a significant global health challenge. Here, we report the preparation and screening of a series of 4-anilinoquinoline libr
Externí odkaz:
https://doaj.org/article/413b3b978f5e4268992a7f1a6a1c76ef
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151616 (2016)
Chikungunya virus (CHIKV; genus Alphavirus, family Togaviridae) has recently caused several major outbreaks affecting millions of people. There are no licensed vaccines or antivirals, and the knowledge of the molecular biology of CHIKV, crucial for d
Externí odkaz:
https://doaj.org/article/3148d0e18a55419294b9bc748444dcf0
Autor:
Margit Mutso, Ainhoa Moliner Morro, Cecilia Smedberg, Sergo Kasvandik, Muriel Aquilimeba, Mona Teppor, Liisi Tarve, Aleksei Lulla, Valeria Lulla, Sirle Saul, Bastian Thaa, Gerald M McInerney, Andres Merits, Margus Varjak
Publikováno v:
Viruses, Vol 10, Iss 5, p 226 (2018)
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae) in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (nsP) (nsP1, nsp2, nsP3 and nsP4) that act as subunits of the virus
Externí odkaz:
https://doaj.org/article/436e6e42498f4d28a75d5d8db1b0d5fb
Autor:
Magnus Essand, Justyna Leja-Jarblad, Andres Merits, Anna Dimberg, Sven Nelander, Sirle Saul, Valeria Lulla, Aleksei Lulla, Lei Zhang, Sathishkumar Baskaran, Matheus Dyczynski, Di Yu, Mohanraj Ramachandran
Background: Glioblastoma multiforme and high-risk neuroblastoma are cancers with poor outcome. Immunotherapy in the form of neurotropic oncolytic viruses is a promising therapeutic approach for these malignancies. Here we evaluate the oncolytic capac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44291d712823d64463f014116a86062d
https://doi.org/10.1158/1078-0432.c.6525494.v1
https://doi.org/10.1158/1078-0432.c.6525494.v1
Autor:
Magnus Essand, Justyna Leja-Jarblad, Andres Merits, Anna Dimberg, Sven Nelander, Sirle Saul, Valeria Lulla, Aleksei Lulla, Lei Zhang, Sathishkumar Baskaran, Matheus Dyczynski, Di Yu, Mohanraj Ramachandran
Supplementary material and methods Supplementary Table 1: miR124, miR125 and miR134 expression relative to human or mouse U6 snRNA in normal mouse CNS tissues, mouse neural stem cells, in vitro-differentiated mouse brain cells, mouse neuroblastoma, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5d2ca48e231cfec5e2bb2a20cf9eee
https://doi.org/10.1158/1078-0432.22463723
https://doi.org/10.1158/1078-0432.22463723
Autor:
Stanford Schor, Szuyuan Pu, Vlad Nicolaescu, Siavash Azari, Mardo Kõivomägi, Marwah Karim, Patricia Cassonnet, Sirle Saul, Gregory Neveu, Andrew Yueh, Caroline Demeret, Jan M. Skotheim, Yves Jacob, Glenn Randall, Shirit Einav
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, 2022, pp.101956. ⟨10.1016/j.jbc.2022.101956⟩
Journal of Biological Chemistry, 2022, pp.101956. ⟨10.1016/j.jbc.2022.101956⟩
International audience; The signaling pathways and cellular functions regulated by the four Numb-associated kinases (NAKs) are largely unknown. We previously reported that AAK1 and GAK control intracellular trafficking of RNA viruses, and recently re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9961ff199620304c8a2dda090507e7
https://hal-pasteur.archives-ouvertes.fr/pasteur-03675835
https://hal-pasteur.archives-ouvertes.fr/pasteur-03675835