Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Sirkku T, Saarikoski"'
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71450 (2013)
People with mood disorders often have disruptions in their circadian rhythms. Recent molecular genetics has linked circadian clock genes to mood disorders. Our objective was to study two core circadian clock genes, CRY1 and CRY2 as well as TTC1 that
Externí odkaz:
https://doaj.org/article/8b540410fa7f4b3990d0efb0ad52c55b
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e10007 (2010)
BACKGROUND: Circadian clocks guide the metabolic, cell-division, sleep-wake, circadian and seasonal cycles. Abnormalities in these clocks may be a health hazard. Circadian clock gene polymorphisms have been linked to sleep, mood and metabolic disorde
Externí odkaz:
https://doaj.org/article/954b6080c3ab491c83f0f9e91fc8739e
Autor:
Hannu Alho, Sirkku T. Saarikoski, Maiju Pankakoski, Leena Kovanen, Syaron Basnet, Sari Castrén, Timo Partonen, Tuuli Lahti
Publikováno v:
European Addiction Research. 22(2):70-79
Background/Aims: Effective treatment strategies are needed for the treatment of pathological gambling (PG). The efficacy of as-needed naltrexone was assessed in a single-centre, randomised, double-blind, placebo-controlled trial. Methods: The partici
Autor:
Seppo Koskinen, Kaisa Silander, Sirkku T. Saarikoski, Noora Rouvinen-Lagerström, Leena Kovanen, Johan G. Eriksson, Katri Räikkönen, Jari Lahti, Aarno Palotie, David A. Sinclair, Hannu Alho, Mauri Aalto, Timo Partonen
Publikováno v:
Alcohol and Alcoholism (Oxford, Oxfordshire)
Aims: The molecular epidemiological studies on the association of the opioid receptor µ-1 (OPRM1) polymorphism A118G (Asn40Asp, rs1799971) and alcohol use disorders have given conflicting results. The aim of this study was to test the possible assoc
Publikováno v:
European Journal of Pharmacology. 687:9-13
Earlier findings suggest that, in addition to its well-known neurotrophic role, brain-derived neurotrophic factor (BDNF) is also involved in the rewarding and reinforcing effects of drugs of abuse. The purpose of the present study was to examine the
Publikováno v:
Alcohol. 45:421-426
In our previous studies on alcohol-preferring AA (Alko alcohol) and nonpreferring ANA (Alko nonalcohol) rats, we have observed that the AA rats exhibit lower endogenous levels of corticosterone, higher testosterone levels, and more frequent alcohol-i
Autor:
Arpo Aromaa, Timo Partonen, Leena Kovanen, Sirkku T. Saarikoski, Sami Pirkola, Jari Haukka, Jouko Lönnqvist
Publikováno v:
Alcohol and Alcoholism. 45:303-311
Aims: Circadian clock genes are involved in the development of drug-induced behaviors and regulate neurotransmission pathways in addiction. Our aim was to study whether circadian clock gene polymorphisms predispose to alcohol dependence or abuse or o
Autor:
Feng Wang, Steven P. Rivera, Ruixue Zhang, Oliver Hankinson, B. E. Chapman, Sirkku T. Saarikoski, Robert T. Taylor
Publikováno v:
Journal of Biological Chemistry. 282:10881-10893
Cytochrome P4502S1 (CYP2S1) is expressed at high levels in epithelial tissues and is inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) via the aryl hydrocarbon receptor (AHR). Transcriptional initiation of mouse Cyp2s1 was found to occur at t
Publikováno v:
Xenobiotica. 37:271-279
Representational difference analysis (RDA) was employed on dioxin-stimulated Hepa-1 mouse hepatoma cells (human breast cancer) MCF-7 cells, mouse liver, and mouse thymocytes in order to identify novel responder genes to dioxin. In addition to several
Autor:
Tom Böhling, Päivi Heikkilä, Caj Haglund, Sirkku T. Saarikoski, Lea Pylkkänen, Markku Sainio, Sebsebe Lemeta, Kirsti Husgafvel-Pursiainen, Johanna Arola, Kaisa Salmenkivi
Publikováno v:
Human Pathology. 37:749-754
Multiple genetic alterations have been associated with pheochromocytoma (PCC). Most PCCs are sporadic, but they also occur in inherited tumor syndromes, including von Hippel-Lindau disease. Although the etiology of most inherited PCCs is well documen