Peptide dendrimers as “lead compounds” for the treatment of chronic lung infections by Pseudomonas aeruginosa in cystic fibrosis patients: in vitro and in vivo studies

Autor: Pompilio A, Geminiani C, Mantini P, Siriwardena TN, Di Bonaventura I, Reymond JL, Di Bonaventura G

Publikováno v: Infection and Drug Resistance, Vol Volume 11, Pp 1767-1782 (2018)

Arianna Pompilio,1,2 Cristina Geminiani,1,2 Paolo Mantini,1,2 Thissa N Siriwardena,3 Ivan Di Bonaventura,3 Jean Louis Reymond,3 Giovanni Di Bonaventura1,2 1Department of Medical, Oral, and Biotechnological Sciences, G d’Annunzio University of Chiet

Externí odkaz: https://doaj.org/article/ba13f2ac69f94f3295ea7cf75065653b

Stereorandomization as a Method to Probe Peptide Bioactivity.

Autor: Siriwardena TN; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland., Gan BH; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland., Köhler T; Department of Microbiology and Molecular Medicine, University of Geneva, Service of Infectious Diseases, University Hospital of Geneva, 1211 Geneva, Switzerland., van Delden C; Department of Microbiology and Molecular Medicine, University of Geneva, Service of Infectious Diseases, University Hospital of Geneva, 1211 Geneva, Switzerland., Javor S; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland., Reymond JL; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012 Bern, Switzerland.

Publikováno v: ACS central science [ACS Cent Sci] 2021 Jan 27; Vol. 7 (1), pp. 126-134. Date of Electronic Publication: 2021 Jan 19.

Peptide dendrimers G3KL and TNS18 inhibit Pseudomonas aeruginosa biofilms.

Autor: Han X; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Liu Y; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Ma Y; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Zhang M; Electricity Information and Automation College, Civil Aviation University of China, Tianjin, 300300, China., He Z; Key Laboratory of Systems Biology, State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China., Siriwardena TN; Department of Chemistry and Biochemistry, University of Bern, 3012, Bern, Switzerland., Xu H; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Bai Y; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Zhang X; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China., Reymond JL; Department of Chemistry and Biochemistry, University of Bern, 3012, Bern, Switzerland. jean-louis.reymond@dcb.unibe.ch., Qiao M; The Key Laboratory of Molecular Microbiology and Technology Ministry of Education, Nankai University, Tianjin, 300071, China. mingqiangqiao@aliyun.com.

Publikováno v: Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2019 Jul; Vol. 103 (14), pp. 5821-5830. Date of Electronic Publication: 2019 May 17.

Optimizing Antimicrobial Peptide Dendrimers in Chemical Space.

Autor: Siriwardena TN; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland., Capecchi A; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland., Gan BH; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland., Jin X; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland., He R; Shanghai Space Peptides Pharmaceutical Co., Ltd., Shanghai, 201210, China., Wei D; Department of General Surgery, Lanzhou General Hospital of Lanzhou Military Region, PLA, 333 South Binhe Road, Qilihe District, Lanzhou, Gansu Province, 730046, China., Ma L; Lanzhou Ruibei Pharmaceutical R&D Co., Ltd., Lanzhou, Gansu Province, 730000, China., Köhler T; Department of Microbiology and Molecular Medicine, University of Geneva.; Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland., van Delden C; Department of Microbiology and Molecular Medicine, University of Geneva.; Service of Infectious Diseases, University Hospital of Geneva, Geneva, Switzerland., Javor S; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland., Reymond JL; Department of Chemistry and Biochemistry, University of Bern, Freiestrasse 3, 3012, Bern, Switzerland.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Jul 09; Vol. 57 (28), pp. 8483-8487. Date of Electronic Publication: 2018 Jun 15.

Lipidated Peptide Dendrimers Killing Multidrug-Resistant Bacteria.

Autor: Siriwardena TN; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., Stach M; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., He R; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland.; Shanghai Space Peptides Pharmaceutical Co. Ltd , Shanghai 201210, China., Gan BH; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., Javor S; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., Heitz M; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., Ma L; Shanghai Space Peptides Pharmaceutical Co. Ltd , Shanghai 201210, China.; College of Pharmacy, Gansu University of Chinese Medicine , Dingxi East Road 35, Chenguan District, Lanzhou, Gansu Province 730000, China.; Lanzhou Ruibei Pharmaceutical R&D Co., Ltd. , Lanzhou, Gansu Province 730000, China., Cai X; College of Pharmacy, Gansu University of Chinese Medicine , Dingxi East Road 35, Chenguan District, Lanzhou, Gansu Province 730000, China., Chen P; Department of General Surgery, Lanzhou General Hospital of Lanzhou Military Region , PLA, 333 South Binhe Road, Qilihe District, Lanzhou, Gansu Province 730046, China., Wei D; Department of General Surgery, Lanzhou General Hospital of Lanzhou Military Region , PLA, 333 South Binhe Road, Qilihe District, Lanzhou, Gansu Province 730046, China., Li H; Department of General Surgery, Lanzhou General Hospital of Lanzhou Military Region , PLA, 333 South Binhe Road, Qilihe District, Lanzhou, Gansu Province 730046, China., Ma J; College of Pharmacy, Gansu University of Chinese Medicine , Dingxi East Road 35, Chenguan District, Lanzhou, Gansu Province 730000, China., Köhler T; Department of Microbiology and Molecular Medicine, University of Geneva , CH-1211 Geneva, Switzerland., van Delden C; Department of Microbiology and Molecular Medicine, University of Geneva , CH-1211 Geneva, Switzerland.; Service of Infectious Diseases, University Hospital of Geneva , CH-1205 Geneva, Switzerland., Darbre T; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland., Reymond JL; Department of Chemistry and Biochemistry, University of Bern , Freiestrasse 3, 3012 Bern, Switzerland.

Publikováno v: Journal of the American Chemical Society [J Am Chem Soc] 2018 Jan 10; Vol. 140 (1), pp. 423-432. Date of Electronic Publication: 2017 Dec 19.