Phenotypic and transcriptomic profiling of induced pluripotent stem cell (iPSC)-derived NK cells and their cytotoxicity against cancers

Autor: Nontaphat Thongsin, Siriwal Suwanpitak, Punn Augsornworawat, Jakkrapatra Srisantitham, Kritayaporn Saiprayong, Piroon Jenjaroenpun, Methichit Wattanapanitch

Publikováno v: Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Background Adoptive immunotherapy using natural killer (NK) cells has attracted considerable interest in numerous clinical trials targeting both hematological and solid tumors. Traditionally, NK cells are primarily derived from either periph

Externí odkaz: https://doaj.org/article/802af8144b704e238751384c7815d68f

CRISPR-Cas9-mediated disruption of B2M and CIITA genes eliminates HLA class I and II expression in human induced pluripotent stem cells (MUSIi001-A-2)

Autor: Nontaphat Thongsin, Siriwal Suwanpitak, Methichit Wattanapanitch

Publikováno v: Stem Cell Research, Vol 71, Iss , Pp 103138- (2023)

Cell-based therapy offers great promise for treating degenerative diseases. Although autologous cell-based therapy is ideal, it may be impractical due to the high manufacturing cost and long production time. Allogeneic cell-based therapy offers a mor

Externí odkaz: https://doaj.org/article/cd08ccb8e2f94c319949d2347b901b06

Generation of an induced pluripotent stem cell line (MUSIi014-A) from an affected member of a family with autosomal dominant diabetes carrying p.L475P mutation in ZYG11A gene associated with a cell cycle arrest in beta-cell

Autor: Chutima Chanprasert, Nutchanawan Promnakhon, Nontaphat Thongsin, Siriwal Suwanpitak, Nattachet Plengvidhya, Pa-thai Yenchitsommanus, Prapaporn Jungtrakoon Thamtarana, Methichit Wattanapanitch

Publikováno v: Stem Cell Research, Vol 60, Iss , Pp 102715- (2022)

A heterozygous mutation (c.T1424C: p.L475P) in ZYG11A completely segregating with hyperglycemia in a Thai family with familial diabetes of the adulthood has been reported as a cause of cell cycle arrest in 1.1B4 cell line. This mutation is a suggesti

Externí odkaz: https://doaj.org/article/1698d188bf40400585f2e0b6540363e5

Multilineage differentiation potential of hematoendothelial progenitors derived from human induced pluripotent stem cells

Autor: Chinnavuth Vatanashevanopakorn, Chartsiam Tipgomut, Ratchapong Netsrithong, Bootsakorn Boonkaew, Lung-Ji Chang, Methichit Wattanapanitch, Siriwal Suwanpitak, Kongtana Trakarnsanga, Kovit Pattanapanyasat

Publikováno v: Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-15 (2020)
Stem Cell Research and Therapy, 11(1):481. BioMed Central
Netsrithong, R, Suwanpitak, S, Boonkaew, B, Trakarnsanga, K, Chang, L J, Tipgomut, C, Vatanashevanopakorn, C, Pattanapanyasat, K & Wattanapanitch, M 2020, ' Multilineage differentiation potential of hematoendothelial progenitors derived from human induced pluripotent stem cells ', Stem Cell Research and Therapy, vol. 11, no. 1, 481 . https://doi.org/10.1186/s13287-020-01997-w
Stem Cell Research & Therapy

Background Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/feeder-free differentiation prot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa1acdda04318b24a178313d1fbcdde
http://link.springer.com/article/10.1186/s13287-020-01997-w

Efficient generation of endothelial cells from induced pluripotent stem cells derived from a patient with peripheral arterial disease

Autor: Bootsakorn Boonkaew, Siriwal Suwanpitak, Kovit Pattanapanyasat, Nuttawut Sermsathanasawadi, Methichit Wattanapanitch

Publikováno v: Cell and tissue research. 388(1)

Peripheral arterial disease (PAD) is caused by atherosclerotic plaque accumulation, which results in ischemia in lower extremity ischemia. Cell-based therapy using endothelial progenitor cells (EPCs) or endothelial cells (ECs) has been challenging du

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a2216212e6838687224b1b8301f53d
https://pubmed.ncbi.nlm.nih.gov/35072793