APP dyshomeostasis in the pathogenesis of Alzheimer's disease: implications for current drug targets.

Autor: Sirisi S; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Sánchez-Aced É; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Belbin O; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Lleó A; Sant Pau Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Sant Quintí 77, Barcelona, 08041, Spain. alleo@santpau.es.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Jun 29; Vol. 16 (1), pp. 144. Date of Electronic Publication: 2024 Jun 29.

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer's Disease Pathogenesis

Autor: Borras, C, Mercer, A, Sirisi, S, Alcolea, D, Escola-Gil, JC, Blanco-Vaca, F, Tondo, M

Publikováno v: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname

The main aim of this work is to review the mechanisms via which high-density lipoprotein (HDL)-mediated cholesterol trafficking through the central nervous system (CNS) occurs in the context of Alzheimer's disease (AD). Alzheimer's disease is charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::f40dcb3d7a1141e3ca24cb0a881f036c
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12274

Synaptic oligomeric tau in Alzheimer's disease - A potential culprit in the spread of tau pathology through the brain.

Autor: Colom-Cadena M; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Davies C; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Sirisi S; Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Lee JE; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh, UK; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4 UU Edinburgh, UK., Simzer EM; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Tzioras M; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Querol-Vilaseca M; Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Sánchez-Aced É; Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Chang YY; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Holt K; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., McGeachan RI; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Rose J; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Tulloch J; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Wilkins L; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK., Smith C; Centre for Clinical Brain Sciences and Sudden Death Brain Bank, The University of Edinburgh, Edinburgh, UK., Andrian T; Nanoscopy for Nanomedicine Lab, Institute of Bioengineering of Catalonia (IBEC Barcelona Institute of Science and Technology), Barcelona, Spain., Belbin O; Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Pujals S; Department of Biological Chemistry, Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, Spain., Horrocks MH; EaStCHEM School of Chemistry, The University of Edinburgh, Edinburgh, UK; IRR Chemistry Hub, Institute for Regeneration and Repair, The University of Edinburgh, EH16 4 UU Edinburgh, UK., Lleó A; Memory Unit, Department of Neurology, Institut d'Investigacions Biomèdiques Sant Pau - Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. Electronic address: alleo@santpau.cat., Spires-Jones TL; The University of Edinburgh Centre for Discovery Brain Sciences and UK Dementia Research Institute, Edinburgh, UK. Electronic address: Tara.spires-jones@ed.ac.uk.

Publikováno v: Neuron [Neuron] 2023 Jul 19; Vol. 111 (14), pp. 2170-2183.e6. Date of Electronic Publication: 2023 May 15.

Myelin loss in C9orf72 hexanucleotide expansion carriers.

Autor: Sirisi S; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Querol-Vilaseca M; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Dols-Icardo O; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Pegueroles J; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Montal V; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Muñoz L; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Torres S; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Ferrer-Raventós P; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Iulita MF; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Sánchez-Aced É; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Blesa R; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Illán-Gala I; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Molina-Porcel L; Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain., Borrego-Ecija S; Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Sánchez-Valle R; Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.; Alzheimer's Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain., Clarimon J; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain., Belbin O; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Fortea J; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Lleó A; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.; Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.

Publikováno v: Journal of neuroscience research [J Neurosci Res] 2022 Oct; Vol. 100 (10), pp. 1862-1875. Date of Electronic Publication: 2022 Jun 29.

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer's Disease Pathogenesis.

Autor: Borràs C; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; CIBERDEM, ISCIII, 28029 Madrid, Spain.; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain., Mercer A; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain., Sirisi S; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain., Alcolea D; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.; CIBERNED, ISCIII, 28029 Madrid, Spain., Escolà-Gil JC; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; CIBERDEM, ISCIII, 28029 Madrid, Spain., Blanco-Vaca F; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; CIBERDEM, ISCIII, 28029 Madrid, Spain.; Department of Biochemistry and Molecular Biology, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.; Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain., Tondo M; Institut d'Investigació Biomèdica Sant Pau (IIB), Sant Quintí 77-79, 08041 Barcelona, Spain.; CIBERDEM, ISCIII, 28029 Madrid, Spain.; Department of Biochemistry, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, Spain.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Aug 19; Vol. 23 (16). Date of Electronic Publication: 2022 Aug 19.