Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Sirintra, Nakjang"'
Autor:
Erhan Aptullahoglu, Sirintra Nakjang, Jonathan P. Wallis, Helen Marr, Scott Marshall, Elaine Willmore, John Lunec
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1388 (2024)
Chronic lymphocytic leukemia (CLL) is a genetically and clinically diverse hematological cancer affecting middle-aged and elderly individuals. Novel targeted therapy options are needed for patients who relapse following initial responses or who are i
Externí odkaz:
https://doaj.org/article/d985462f94fb48a19b17942c67dfd921
Autor:
Marco Youssef William Zaki, Ahmed Khairallah Mahdi, Gillian Lucinda Patman, Anna Whitehead, João Pais Maurício, Misti Vanette McCain, Despina Televantou, Sameh Abou-Beih, Erik Ramon-Gil, Robyn Watson, Charlotte Cox, Jack Leslie, Caroline Wilson, Olivier Govaere, John Lunec, Derek Austin Mann, Sirintra Nakjang, Fiona Oakley, Ruchi Shukla, Quentin Mark Anstee, Dina Tiniakos, Helen Louise Reeves
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) associated hepatocellular carcinoma (HCC) is rising, even in the absence of cirrhosis. We aimed to develop a murine model that would facilitate further understanding of
Externí odkaz:
https://doaj.org/article/c2466e2014fe4723915552556b300a2b
Autor:
Marcela B. Mansur, Caroline L. Furness, Sirintra Nakjang, Amir Enshaei, Donat Alpar, Sue M. Colman, Lynne Minto, Julie Irving, Beth V. Poole, Elda P. Noronha, Suvi Savola, Sameena Iqbal, John Gribben, Maria S. Pombo‐de‐Oliveira, Tony M. Ford, Mel F. Greaves, Frederik W. vanDelft
Publikováno v:
Cancer Medicine, Vol 10, Iss 14, Pp 4864-4873 (2021)
Abstract Background Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T‐cell acute lymphoblastic leukemia (T‐ALL). Understanding the biology of disease in this age group and the
Externí odkaz:
https://doaj.org/article/7d97ea0a9eda427ea4c2aec1f542ddc1
Autor:
Vasily V. Grinev, Farnaz Barneh, Ilya M. Ilyushonak, Sirintra Nakjang, Job Smink, Anita van Oort, Richard Clough, Michael Seyani, Hesta McNeill, Mojgan Reza, Natalia Martinez-Soria, Salam A. Assi, Tatsiana V. Ramanouskaya, Constanze Bonifer, Olaf Heidenreich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5’UTR, altering isoform expression, and controlling
Externí odkaz:
https://doaj.org/article/5eec00d838bf48d7a8a72e936547e1a8
Autor:
Hasan Issa, Laura E. Swart, Milad Rasouli, Minoo Ashtiani, Sirintra Nakjang, Nidhi Jyotsana, Konstantin Schuschel, Michael Heuser, Helen Blair, Olaf Heidenreich
Publikováno v:
Leukemia, 37(4), 820-834. Nature Publishing Group
A hallmark of acute myeloid leukaemias (AMLs) are chromosomal rearrangements that give rise to novel leukaemia-specific fusion genes. Most of these fusion genes are both initiating and driving events in AML and therefore constitute ideal therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abea678692d46c2d675b29c5d9f8dfea
https://pure.eur.nl/en/publications/119613f2-5cef-4bf9-b98e-f1284945767c
https://pure.eur.nl/en/publications/119613f2-5cef-4bf9-b98e-f1284945767c
Autor:
Paul B. Sinclair, Ruth E. Cranston, Prahlad Raninga, Joanna Cheng, Rebecca Hanna, Zoe Hawking, Steven Hair, Sarra L. Ryan, Amir Enshaei, Sirintra Nakjang, Vikki Rand, Helen J. Blair, Anthony V. Moorman, Olaf Heidenreich, Christine J. Harrison
Publikováno v:
Leukemia. 37:636-649
A common problem in the study of human malignancy is the elucidation of cancer driver mechanisms associated with recurrent deletion of regions containing multiple genes. Taking B-cell acute lymphoblastic leukaemia (B-ALL) and large deletions of 6q [d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95ccc2160b30d60b2c3c0b3b3ac00c89
https://doi.org/10.1038/s41375-023-01816-0
https://doi.org/10.1038/s41375-023-01816-0
Autor:
Yuzhe Shi, Melanie C. Beckett, Helen J. Blair, Ricky Tirtakusuma, Sirintra Nakjang, Amir Enshaei, Christina Halsey, Josef Vormoor, Olaf Heidenreich, Anja Krippner-Heidenreich, Frederik W. van Delft
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
T-cell Acute Lymphoblastic Leukemia (T-ALL) is frequently characterized by glucocorticoid (GC) resistance, which is associated with inferior outcomes, thus highlighting the need for novel therapeutic approaches for GC resistant T-ALL. The pTCR/TCR si
Externí odkaz:
https://doaj.org/article/ecb56e8372c24effab7c346052370ef0
Autor:
Paul Milne, Helen J. Blair, Cornelia Eckert, Zoya Kingsbury, Matthew Collin, Anetta Ptasinska, Alex Elder, Roderick Skinner, Janine Stutterheim, Jennifer Becq, Elena Zerkalenkova, Constanze Bonifer, Denis M. Schewe, Peter N. Cockerill, N Martinez-Soria, Oskar A. Haas, Peter Carey, Katarzyna Szoltysek, Deepali Pal, Hesta McNeill, Claus Meyer, Maria Rosaria Imperato, James C. Mulloy, Mark Wunderlich, Catherine Cargo, Paul Evans, Sarah E. Fordham, Shan Lin, Pierre Cauchy, Y Shi, Simon Bailey, Salam A. Assi, Rolf Marschalek, Josef Vormoor, Olaf Heidenreich, A Komkov, Michael J. Thirman, Simon Bomken, Ricky Tirtakusuma, Sirintra Nakjang, Fotini Vogiatzi, James M. Allan, Lisa J. Russell, Jayne Y. Hehir-Kwa, Muzlifah Haniffa, Yulia Olshanskaya, Vasily V. Grinev, Christine J. Harrison, Venetia Bigley, Daniel Williamson, Alex Smith, Natalia Miakova
Publikováno v:
Blood. 140:1875-1890
The fusion gene MLL-AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukaemia. However, relapse can be associated with a switch from acute lymphoblastic to acute myeloid leukaemia. Here we show that these myeloid relapses share oncogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfc1d67bb85567d28d48decb91162f8
https://doi.org/10.1182/blood.2021015036
https://doi.org/10.1182/blood.2021015036
Autor:
Sven-A. Freibert, Alina V. Goldberg, Christian Hacker, Sabine Molik, Paul Dean, Tom A. Williams, Sirintra Nakjang, Shaojun Long, Kacper Sendra, Eckhard Bill, Eva Heinz, Robert P. Hirt, John M Lucocq, T. Martin Embley, Roland Lill
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The functions of the highly reduced mitochondria (mitosomes) of microsporidians are not well-characterized. Here, the authors show that theTrachipleistophora hominismitosome is the site of iron–sulfur cluster assembly and that its retention is like
Externí odkaz:
https://doaj.org/article/e78ff76691884b4cabe49d811630fe3d
Autor:
Zainab Adnan Hatem Alebady, Mahsa Azizyan, Sirintra Nakjang, Emma Lishman-Walker, Dhuha Al-Kharaif, Hui Xian Choo, Rebecca Garnham, Emma Scott, Katya Leonie Johnson, Craig Robson, Kelly Coffey
The methyltransferase, KMT5A has been proposed as an oncogene in prostate cancer and therefore represents a putative therapeutic target. To confirm this hypothesis we have performed a microarray study in a prostate cancer cell line model of androgen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9125853eaf995146cda7c610d2c71fc
https://doi.org/10.20944/preprints202305.2047.v1
https://doi.org/10.20944/preprints202305.2047.v1
