Výsledky vyhledávání - "Siri Tahtinen"

Akademický článek

Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus

Autor: Riikka Havunen, João M. Santos, Suvi Sorsa, Tommi Rantapero, Dave Lumen, Mikko Siurala, Anu J. Airaksinen, Victor Cervera-Carrascon, Siri Tähtinen, Anna Kanerva, Akseli Hemminki

Publikováno v: Molecular Therapy: Oncolytics, Vol 11, Iss , Pp 109-121 (2018)

Cancer treatment with local administration of armed oncolytic viruses could potentially induce systemic antitumor effects, or the abscopal effect, as they self-amplify in tumors, induce danger signaling, and promote tumor-associated antigen presentat

Externí odkaz: https://doaj.org/article/7c4bd36ebe464f6dac1aacc59f618b2a

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Akademický článek

Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy

Autor: Riikka Havunen, Mikko Siurala, Suvi Sorsa, Susanna Grönberg-Vähä-Koskela, Michael Behr, Siri Tähtinen, João Manuel Santos, Pauliina Karell, Juuso Rusanen, Dirk M. Nettelbeck, Anja Ehrhardt, Anna Kanerva, Akseli Hemminki

Publikováno v: Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 77-86 (2017)

Adoptive cell therapy holds much promise in the treatment of cancer but results in solid tumors have been modest. The notable exception is tumor-infiltrating lymphocyte (TIL) therapy of melanoma, but this approach only works with high-dose preconditi

Externí odkaz: https://doaj.org/article/ee6fb35e852f4da1817ebf04ed9d2d6f

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Akademický článek

A novel in silico framework to improve MHC-I epitopes and break the tolerance to melanoma

Autor: Cristian Capasso, Aniket Magarkar, Victor Cervera-Carrascon, Manlio Fusciello, Sara Feola, Martin Muller, Mariangela Garofalo, Lukasz Kuryk, Siri Tähtinen, Lucio Pastore, Alex Bunker, Vincenzo Cerullo

Publikováno v: OncoImmunology, Vol 6, Iss 9 (2017)

Tolerance toward tumor antigens, which are shared by normal tissues, have often limited the efficacy of cancer vaccines. However, wild type epitopes can be tweaked to activate cross-reactive T-cell clones, resulting in antitumor activity. The design

Externí odkaz: https://doaj.org/article/ddd72ddd9f2b4261bd0444b04f94d915

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Akademický článek

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

Autor: Sadia Zafar, Suvi Parviainen, Mikko Siurala, Otto Hemminki, Riikka Havunen, Siri Tähtinen, Simona Bramante, Lotta Vassilev, Hongjie Wang, Andre Lieber, Silvio Hemmi, Tanja de Gruijl, Anna Kanerva, Akseli Hemminki

Publikováno v: OncoImmunology, Vol 6, Iss 2 (2017)

Vaccination with dendritic cells (DCs), the most potent professional antigen-presenting cells in the body, is a promising approach in cancer immunotherapy. However, tumors induce immunosuppression in their microenvironment that suppresses and impairs

Externí odkaz: https://doaj.org/article/566dc122487a44029d2368a84af28d7a

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Akademický článek

Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.

Autor: Siri Tähtinen, Saija Kaikkonen, Maiju Merisalo-Soikkeli, Susanna Grönberg-Vähä-Koskela, Anna Kanerva, Suvi Parviainen, Markus Vähä-Koskela, Akseli Hemminki

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0131242 (2015)

Unfavorable ratios between the number and activation status of effector and suppressor immune cells infiltrating the tumor contribute to resistance of solid tumors to T-cell based therapies. Here, we studied the capacity of FDA and EMA approved recom

Externí odkaz: https://doaj.org/article/41a59eecd82545118ec1428efba0a1ea

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Akademický článek

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

Autor: Mathias Vormehr, Sophie Lehar, Lena M. Kranz, Siri Tahtinen, Yoko Oei, Vincent Javinal, Lélia Delamarre, Kerstin C. Walzer, Mustafa Diken, Sebastian Kreiter, Ira Mellman, Ugur Sahin, Jill M. Schartner, Özlem Türeci

Publikováno v: OncoImmunology, Vol 9, Iss 1 (2020)

Glucocorticosteroids (GCS) have an established role in oncology and are administered to cancer patients in routine clinical care and in drug development trials as co-medication. Given their strong immune-suppressive activity, GCS may interfere with i

Externí odkaz: https://doaj.org/article/8226105be4244dba8929cab8e349dfef

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