Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Siri Kalyan Chirumamilla"'
Autor:
Janak R. Wedagedera, Anthonia Afuape, Siri Kalyan Chirumamilla, Hiroshi Momiji, Robert Leary, Mike Dunlavey, Richard Matthews, Khaled Abduljalil, Masoud Jamei, Frederic Y. Bois
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 755-765 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) models usually include a large number of parameters whose values are obtained using in vitro to in vivo extrapolation. However, such extrapolations can be uncertain and may benefit from inclusio
Externí odkaz:
https://doaj.org/article/b22a6cafc47a40658b0d29adf692a9fc
Autor:
Chunyan Han, Tiancheng Sun, Siri Kalyan Chirumamilla, Frederic Y. Bois, Mandy Xu, Amin Rostami-Hodjegan
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2237 (2023)
The most common method for establishing bioequivalence (BE) is to demonstrate similarity of concentration–time profiles in the systemic circulation, as a surrogate to the site of action. However, similarity of profiles from two formulations in the
Externí odkaz:
https://doaj.org/article/f7821e2ed5894eadb52805257af7eb9e
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1169 (2021)
Acid reducing agents (ARAs) reduce the dissolution rate of weakly basic drugs in the stomach potentially leading to lower bioavailability. Formulating the API as a rapidly dissolving salt is one strategy employed to reduce the impact of ARAs on disso
Externí odkaz:
https://doaj.org/article/31f5d7c1c0e64c6d830ac435beef09f3