Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sira, Gevers"'
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
In p53-deficient colorectal cancer organoids, 5-fluorouracil induces pyrimidine imbalance, which causes DNA damage and cell death. Rewiring glucose metabolism through PDK inhibition by DCA enhances 5-FU toxicity in glycolytic p53-deficient organoids.
Externí odkaz:
https://doaj.org/article/c8a2e24e3c664ab7b22d3021e93d4b64
Autor:
Marlies C. Ludikhuize, Sira Gevers, Nguyen T. B. Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin C. A. Stigter, Jarno Drost, Hans Clevers, Boudewijn M. T. Burgering, Maria J. Rodríguez Colman
Publikováno v:
Communications Biology, 5(1). Nature Research
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4c6e385e7fdeaa49121f97775fe202
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
https://pure.knaw.nl/portal/en/publications/cd17bb28-70e5-4147-9b15-94394daf0df3
Autor:
Marlies Ludikhuize, Sira Gevers, Nguyen Nguyen, Maaike Meerlo, S. Khadijeh Shafiei Roudbari, M. Can Gulersonmez, Edwin Stigter, Jarno Drost, Hans Clevers, Boudewijn Burgering, Maria Rodríguez Colman
5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), however response rates in patients are limited to 50%. Unexpectedly, the molecular mechanisms by which 5-FU ultimately induces toxicity remain debated, limiting the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b473c13f15b7a7f6117bf5b784439ef
https://doi.org/10.21203/rs.3.rs-1054076/v1
https://doi.org/10.21203/rs.3.rs-1054076/v1
Autor:
Marlies C, Ludikhuize, Sira, Gevers, Nguyen T B, Nguyen, Maaike, Meerlo, S Khadijeh Shafiei, Roudbari, M Can, Gulersonmez, Edwin C A, Stigter, Jarno, Drost, Hans, Clevers, Boudewijn M T, Burgering, Maria J, Rodríguez Colman
Publikováno v:
Communications biology. 5(1)
Despite the fact that 5-fluorouracil (5-FU) is the backbone for chemotherapy in colorectal cancer (CRC), the response rates in patients is limited to 50%. The mechanisms underlying 5-FU toxicity are debated, limiting the development of strategies to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3979969f46d2d108887abde4150a538
https://pubmed.ncbi.nlm.nih.gov/36316440
https://pubmed.ncbi.nlm.nih.gov/36316440