Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Siqun Zhou"'
Autor:
Vipul Yadav, Aileen House, Silvia Matiz, Laura E. McCoubrey, Kimberly A. Bettano, Leena Bhave, Meiyao Wang, Peter Fan, Siqun Zhou, Janice D. Woodhouse, Eirini Poimenidou, Liu Dou, Abdul W. Basit, Lily Y. Moy, Robert Saklatvala, Laxminarayan G. Hegde, Hongshi Yu
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2385 (2022)
Janus kinase (JAK) inhibitors, such as tofacitinib (Xeljanz) and filgotinib (Jyseleca), have been approved for treatment of ulcerative colitis with several other JAK inhibitors in late-stage clinical trials for inflammatory bowel disease (IBD). Despi
Externí odkaz:
https://doaj.org/article/f846cb0cf29a4fa0a0c6b7c02c1e2aed
Publikováno v:
Sustainability; Volume 15; Issue 8; Pages: 6989
The digital economy is an essential driving force supporting high-quality green development. Based on the panel data of cities in China’s Yangtze River from 2011 to 2020, this paper builds the digital economy evaluation index system from the five d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3ed07d4151aaf81a3fba33c22dcedc
https://doi.org/10.3390/su15086989
https://doi.org/10.3390/su15086989
Autor:
Derek Wiswell, Minchao Chen, SuChun Hsieh, Shuli Zhang, Siqun Zhou, Fahimeh Raoufi, Wolfgang Seghezzi
Publikováno v:
Journal of immunological methods. 494
Peggy Sue is a capillary-based western/immunoassay platform that can separate and characterize proteins by size or charge. A quick and automated immunogenicity assay was developed on Peggy Sue based on charge separation and compared with a traditiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb854c59a14c341713b44ec20123783d
https://pubmed.ncbi.nlm.nih.gov/33775673
https://pubmed.ncbi.nlm.nih.gov/33775673
Autor:
Larry Jang, Xianfeng Li, M. Nuria De Francisco, Steven W. Ferla, J. Russell Grove, Siqun Zhou, Jennifer D. Irvine, Yijun Pan, Caiding Xu, Joy A. Miguel, Natalie Macher, Ashok Bhandari, Christopher P. Holmes, Claire M. Moody, Brian Troy Frederick
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:2719-2724
We have synthesized and evaluated a series of triaryl sulfonamide-based PTP1B inhibitors in which a difluoro-methylenephosphonate group of a potent lead has been replaced by potential bioisosteric replacements. Several mono- or di-charged compounds (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b2e335bf814e75cabe54aa2bb86c94
https://doi.org/10.1016/j.bmcl.2008.03.007
https://doi.org/10.1016/j.bmcl.2008.03.007
Autor:
Theresa Branchek, Lakmal W. Boteju, Raisa Nagorny, Rita Raddatz, Maricel S. Guevarra, Beth Borowsky, Christophe P. G. Gerald, Gabriel S. Lerman, Evguenia V. Kouranova, Amy E. Wilson, Pierre J.-J. Vaysse, Siqun Zhou, Carlos Forray, Nika Adham, Meng Dai, Roman Artymyshyn, James A. Bonini
Publikováno v:
Journal of Biological Chemistry. 275:32452-32459
Two structurally related, G-protein-coupled receptors were identified as receptors for the neuropeptide, neuromedin U. This peptide is found in highest levels in the gut and genitourinary system where it potently contracts smooth muscle but is also e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6e285f2285774657abe34f6411afc6
https://doi.org/10.1074/jbc.m004613200
https://doi.org/10.1074/jbc.m004613200
Autor:
Kui Lin, Lori Friedman, Michael Degtyarev, Jarrod Tremayne, Ulka Vijapurkar, Leanne Ross, Liliane Robillard, Tom Truong, Marcia Belvin, Elizabeth Blackwood, Siqun Zhou, Zhonghua Pei
Publikováno v:
Cancer letters. 326(2)
The mammalian target of rapamycin (mTOR) is a central node in a complex signaling network that is regulated by several pathways deregulated in human cancers, including the PI3K/Akt and MAPK pathways. Targeting mTOR therefore presents an opportunity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8c9e3ae1a9bb3a6ea1640ff7c5bf30
https://pubmed.ncbi.nlm.nih.gov/22902509
https://pubmed.ncbi.nlm.nih.gov/22902509
Autor:
Hua, Xu, Zhuo, Wang, John C, Donaldson, Hong, Yao, Siqun, Zhou, Andrew B, Kelson, Wenli, Ma, Kevin T, Weber, Edgardo, Laborde, Mingshan, Cheng, Lidia, Sambucetti, James G, Keck
Publikováno v:
Anticancer research. 29(10)
DNA-damaging agents are widely used for the treatment of human malignancies. Agents containing the multifunctional alkylating moiety tetrakis(2-chloroethyl)phosphorodiamidic acid are currently under development as cancer therapeutics.TLK58747, a phop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::feabf9394ff7e8b99c1efb2e6a7170e2
https://pubmed.ncbi.nlm.nih.gov/19846918
https://pubmed.ncbi.nlm.nih.gov/19846918
Autor:
J. Russell Grove, Claire M. Moody, Xianfeng Li, Jennifer D. Irvine, Steven W. Ferla, Siqun Zhou, Larry Jang, Joy A. Miguel, Caiding Xu, Brian Troy Frederick, Ashok Bhandari, Yijun Pan, Christopher P. Holmes, Natalie Macher, M. Nuria De Francisco
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
A series of novel sulfonamides containing a single difluoromethylene-phosphonate group were discovered to be potent inhibitors of protein tyrosine phosphatase 1B. Structure–activity relationships around the scaffold were investigated, leading to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb846b06d0d8cf78ef9246c0ae0210d
https://pubmed.ncbi.nlm.nih.gov/16046123
https://pubmed.ncbi.nlm.nih.gov/16046123
Publikováno v:
Fungal genetics and biology : FGB. 21(3)
We have cloned four Neurospora crassa genes by complementation analysis. Cloned genes include the arginine-1 ( arg-1 ), methionine-6 ( met-6 ), unknown-7 ( un-7 ), and ribosome production-1 ( rip-1 ) loci. Chromosome walks were initiated in ordered c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a794e990318b7d56a1980e6aa7a2f6
https://pubmed.ncbi.nlm.nih.gov/9290245
https://pubmed.ncbi.nlm.nih.gov/9290245