Výsledky vyhledávání

Akademický článek

Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer

Autor: Thiago Vidotto, Eddie L. Imada, Farzana Faisal, Sanjana Murali, Adrianna A. Mendes, Harsimar Kaur, Siqun Zheng, Jianfeng Xu, Edward M. Schaeffer, William B. Isaacs, Karen S. Sfanos, Luigi Marchionni, Tamara L. Lotan

Publikováno v: JCI Insight, Vol 8, Iss 3 (2023)

The genomic and immune landscapes of prostate cancer differ by self-identified race. However, few studies have examined the genome-wide copy number landscape and immune content of matched cohorts with genetic ancestry data and clinical outcomes. Here

Externí odkaz: https://doaj.org/article/ecd843645058485e9f5dc48d24f26852

Zobrazit plný text záznamu

Akademický článek

Polygenic risk score is a predictor of adenomatous polyps at screening colonoscopy

Autor: Michael J. Northcutt, Zhuqing Shi, Michael Zijlstra, Ayush Shah, Siqun Zheng, Eugene F. Yen, Omar Khan, Mohammad Imran Beig, Polina Imas, Adam Vanderloo, Obaid Ansari, Jianfeng Xu, Jay L. Goldstein

Publikováno v: BMC Gastroenterology, Vol 21, Iss 1, Pp 1-7 (2021)

Abstract Background Single nucleotide polymorphism (SNP)-based polygenic risk scoring is predictive of colorectal cancer (CRC) risk. However, few studies have investigated the association of genetic risk score (GRS) with detection of adenomatous poly

Externí odkaz: https://doaj.org/article/b7a44f8c28f5494c91b4f7454a98eb10

Zobrazit plný text záznamu

Plný text ve formátu HTML

Abstract PO-100: Association of B7-H3 expression with racial ancestry, immune cell density and AR activation in prostate cancer

Autor: Adrianna A. Mendes, Jiayun Lu, Harsimar B Kaur, Siqun Zheng, Jianfeng Xu, Edward M. Schaeffer, Karen S. Sfanos, Janielle Maynard, Ashley E. Ross, Steven P. Balk, Mary-Ellen Taplin, Emmanuel S. Antonarakis, Corinne E. Joshu, Eugene Shenderov, Tamara L. Lotan

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 31:PO-100

Background: B7-H3 (CD276, PD-L3) is an immunomodulatory molecule highly expressed in prostate cancer and belonging to the B7 superfamily that also includes PD-L1 (B7-H1). Immunotherapies (antibodies, antibody-drug conjugates, and CAR-T cells) targeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ea65e319bd309893be6368c4e9f9f790
https://doi.org/10.1158/1538-7755.disp21-po-100

Zobrazit plný text záznamu

Abstract PO-146: Copy number landscape of primary African-American and European-American prostate tumors

Autor: Thiago Vidotto, Eddie Imada, Farzana Faizal, Siqun Zheng, Jianfeng Xu, Karen S. Sfanos, Luigi Marchionni, Tamara L. Lotan

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 31:PO-146

African-American (AA) men are more likely to be diagnosed with and to die of prostate cancer than their European-American counterparts. Much of this disparity is due to access to care and social determinants of health; however, there is emerging evid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cb486f41817d9faaa34741788bb7aa04
https://doi.org/10.1158/1538-7755.disp21-po-146

Zobrazit plný text záznamu

Akademický článek

Genome-wide association scan for variants associated with early-onset prostate cancer.

Autor: Ethan M Lange, Anna M Johnson, Yunfei Wang, Kimberly A Zuhlke, Yurong Lu, Jessica V Ribado, Gregory R Keele, Jin Li, Qing Duan, Ge Li, Zhengrong Gao, Yun Li, Jianfeng Xu, William B Isaacs, Siqun Zheng, Kathleen A Cooney

Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93436 (2014)

Prostate cancer is the most common non-skin cancer and the second leading cause of cancer related mortality for men in the United States. There is strong empirical and epidemiological evidence supporting a stronger role of genetics in early-onset pro

Externí odkaz: https://doaj.org/article/98d573dd13d54d61b2bd7817179e867d

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání