Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Siquan Chen"'
Autor:
Min Pan, William C. Wright, Richard H. Chapple, Asif Zubair, Manbir Sandhu, Jake E. Batchelder, Brandt C. Huddle, Jonathan Low, Kaley B. Blankenship, Yingzhe Wang, Brittney Gordon, Payton Archer, Samuel W. Brady, Sivaraman Natarajan, Matthew J. Posgai, John Schuetz, Darcie Miller, Ravi Kalathur, Siquan Chen, Jon Patrick Connelly, M. Madan Babu, Michael A. Dyer, Shondra M. Pruett-Miller, Burgess B. Freeman, Taosheng Chen, Lucy A. Godley, Scott C. Blanchard, Elizabeth Stewart, John Easton, Paul Geeleher
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
CX-5461 recently progressed through phase I clinical trial as a first-inhuman inhibitor of RNA-POL I. Here, the authors demonstrate that CX-5461 synergizes with topoisomerase I inhibitors to inhibit neuroblastoma cells and that its primary target in
Externí odkaz:
https://doaj.org/article/eab356ebc3d24e3c88297e4fc7fbc176
Autor:
Andrew D Skol, Segun C Jung, Ana Marija Sokovic, Siquan Chen, Sarah Fazal, Olukayode Sosina, Poulami P Borkar, Amy Lin, Maria Sverdlov, Dingcai Cao, Anand Swaroop, Ionut Bebu, DCCT/EDIC Study group, Barbara E Stranger, Michael A Grassi
Publikováno v:
eLife, Vol 9 (2020)
We determined differential gene expression in response to high glucose in lymphoblastoid cell lines derived from matched individuals with type 1 diabetes with and without retinopathy. Those genes exhibiting the largest difference in glucose response
Externí odkaz:
https://doaj.org/article/fd876869d7b14602a155dc80b39fa088
Publikováno v:
Materials, Vol 15, Iss 7, p 2433 (2022)
Axial extrusion-connection technology is one of the important connection technologies for hydraulic piping systems, with high sealing performance and mechanical strength. In this paper, the finite-element-modeling method is used to simulate the exper
Externí odkaz:
https://doaj.org/article/e50c3e7147db4f02bcb21f0c9be7fff9
Autor:
Andrea E. Murmann, Elizabeth T. Bartom, Matthew J. Schipma, Jacob Vilker, Siquan Chen, Marcus E. Peter
Publikováno v:
iScience, Vol 23, Iss 2, Pp - (2020)
Summary: MicroRNAs (miRNAs) are short double-stranded noncoding RNAs (19-23 nucleotides) that regulate gene expression by suppressing mRNAs through RNA interference. Targeting is determined by the seed sequence (position 2-7/8) of the mature miRNA. A
Externí odkaz:
https://doaj.org/article/d9db1aba7711450a8d10d6d04a200676
Autor:
Quan Q. Gao, William E. Putzbach, Andrea E. Murmann, Siquan Chen, Aishe A. Sarshad, Johannes M. Peter, Elizabeth T. Bartom, Markus Hafner, Marcus E. Peter
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Small interfering (siRNAs) can be toxic to cancer cells. Here the authors investigate the toxicity of microRNA in cancer cells by performing a siRNA screen that tests the miRNA activities of an extensive list of miRNAs with different 6mer seed sequen
Externí odkaz:
https://doaj.org/article/c78972507df3463e9a2616f3688e2bbe
Autor:
Michael A Grassi, Vidhya R Rao, Siquan Chen, Dingcai Cao, Xiaoyu Gao, Patricia A Cleary, R Stephanie Huang, Andrew D Paterson, Rama Natarajan, Jalees Rehman, Timothy S Kern, DCCT/EDIC Research Group
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160504 (2016)
White blood cells have been shown in animal studies to play a central role in the pathogenesis of diabetic retinopathy. Lymphoblastoid cells are immortalized EBV-transformed primary B-cell leukocytes that have been extensively used as a model for con
Externí odkaz:
https://doaj.org/article/e7d108ef4b6e49109b225979ab3f8be2
Autor:
Michael A Grassi, Vidhya Rao, Kathryn P Winkler, Wei Zhang, Joseph D Bogaard, Siquan Chen, Bonnie LaCroix, Divya Lenkala, Jalees Rehman, Asrar B Malik, Nancy J Cox, R Stephanie Huang
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87883 (2014)
ObjectiveTo determine the genetic contribution to leukocyte endothelial adhesion.MethodsLeukocyte endothelial adhesion was assessed through a novel cell-based assay using human lymphoblastoid cell lines. A high-throughput screening method was develop
Externí odkaz:
https://doaj.org/article/8ac2cae563834316b10ab997c85eba30
Publikováno v:
MATEC Web of Conferences; 2024, Vol. 395, p1-6, 6p
Autor:
Jeremiah Y. Kim, Matthew G. Rosenberger, Siquan Chen, Carman KM IP, Azadeh Bahmani, Qing Chen, Jinjing Shen, Yifeng Tang, Andrew Wang, Emma Kenna, Minjun Son, Savaş Tay, Andrew L. Ferguson, Aaron P. Esser-Kahn
Publikováno v:
ACS Central Science. 9:427-439
Autor:
Ernst Lengyel, Marc Ferrer, Juan Marugan, Kyle R. Brimacombe, Yen-Ju Chen, Chun-Yi Chiang, Siquan Chen, Sarah Fazal, Kristen Wroblewski, Dominik A. Nahotko, Betul Kara, Min Shen, Madhu Lal-Nag, Hilary A. Kenny
Supplementary Figure S4 shows the activity of non-lead compounds in secondary biological assays.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa4da14d7c7e052f7a053a7c7a1cad7
https://doi.org/10.1158/1535-7163.22506267.v1
https://doi.org/10.1158/1535-7163.22506267.v1