Evolutionary Stability Optimizer (ESO): A Novel Approach to Identify and Avoid Mutational Hotspots in DNA Sequences While Maintaining High Expression Levels.

Autor: Menuhin-Gruman I; School of Mathematical Sciences, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv, Israel 6997801., Arbel M; Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 6997801., Amitay N; School of Electrical Engineering, The Iby and Aladar Fleischman Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel 6997801., Sionov K; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel 6997801., Naki D; Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 6997801., Katzir I; Shmunis School of Biomedicine and Cancer Research, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel 6997801., Edgar O; School of Medicine, The Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel 6997801., Bergman S; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel 6997801., Tuller T; Department of Biomedical Engineering, Tel Aviv University, Tel Aviv, Israel 6997801.; The Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel 6997801.

Publikováno v: ACS synthetic biology [ACS Synth Biol] 2022 Mar 18; Vol. 11 (3), pp. 1142-1151. Date of Electronic Publication: 2021 Dec 20.