Utility of ctDNA to support patient selection for early phase clinical trials: the TARGET study

Autor: Kristopher K. Frese, Donna M. Graham, Nicholas Hickson, Alexandra Clipson, Crispin J. Miller, Sumitra Mohan, Saba Ferdous, Matthew G Krebs, Alexander J Vickers, Bedirhan Kilerci, Helen Eaton, Caroline Dive, Siobhan Southam, Roopa Kurup, Hannah Frost, Ciara O’Brien, Fiona C Thistlethwaite, Richard Marais, Allan M. Jordan, Mahmood Ayub, Robert Metcalf, Jaseela Chiramel, Louise Carter, Daniel J. White, Emma Dean, Matthew Howell, Sreeja Aruketty, Avinash Gupta, Joanne Dransfield, Ged Brady, Kamrun Nessa, Donal Landers, Claire L. S. Kelly, Shaun Villa, Julie Stevenson, Dominic G. Rothwell, Nigel K Smith, Andrew Hughes, Nadina Tinsley, Natalie Cook, Sakshi Gulati, Andrew L. Wallace

Publikováno v: Rothwell, D, Ayub, M, Cook, N, Thistlethwaite, F, Carter, L, Dean, E, Smith, N, Villa, S, Dransfield, J, Clipson, A, White, D, Nessa, K, Ferdous, S, Howell, M, Gupta, A, Kilerci, B, Mohan, S, Frese, K, Gulati, S, Miller, C, Jordan, A, Eaton, H, Hickson, N, O'Brien, C, Graham, D, Kelly, C, Aruketty, S, Metcalf, R, Chiramel, J, Tinsley, N, Vickers, AJ, Kurup, R, Frost, H, Stevenson, J, Southam, S, Landers, D, Wallace, A, Marais, R, Hughes, AM, Brady, G, Dive, C & Krebs, M 2019, ' Utility of ctDNA to support patient selection for early phase clinical trials: The TARGET Study ', Nature Medicine, vol. 25, no. 5, pp. 738-743 . https://doi.org/10.1038/s41591-019-0380-z, https://doi.org/10.1038/s41591-019-0380-z

Next-generation sequencing (NGS) of circulating tumor DNA (ctDNA) supports blood-based genomic profiling but is not yet routinely implemented in the setting of a phase I trials clinic. TARGET is a molecular profiling program with the primary aim to m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab8deb506ba3c33e67a2a24472d46ac
https://doi.org/10.1038/s41591-019-0380-z

Application of variant interpretation software to decipher pathogenicity of mutations for a molecular tumour board (MTB)

Autor: Donna M. Graham, Matthew G Krebs, Mahmood Ayub, Siobhan Southam, Dominic G. Rothwell, Julie Stevenson

Publikováno v: Annals of Oncology. 30:vii10

Background Comprehensive genomic profiling (CGP) of tumours using next generation sequencing (NGS) is increasingly used to guide management. Broad panel sequencing may increase treatment options by identifying more potential targets but generates lar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cfe323483c8366e66849b4ccc4e2f11
https://doi.org/10.1093/annonc/mdz413.037

Volume 68 Table of Contents.

Publikováno v: Arthritis Care & Research; Dec2016, Vol. 68 Issue 12, p1912-1944, 5p