Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Siobhan Ramcharran"'
Autor:
Charles A. Nicolette, Alexander Steinkasserer, Stephen Brand, Firas Zahr ElDeen, Hao Wang, W. Ge, Jifu Jiang, Bertha Garcia, Jacqueline Arp, Miren L. Baroja, Siobhan Ramcharran, Dameng Lian, Perry Chou, Elisabeth Zinser, Weihua Liu
Publikováno v:
Transplantation. 90:1145-1156
Background. Dendritic cells (DCs) are crucial regulators of immunity and important in inducing and maintaining tolerance. Here, we investigated the potential of a novel DC-immunomodulating agent, soluble CD83 (sCD83), in inducing transplant tolerance
Autor:
Bertha Garcia, Robert Zhong, J. Arp, Siobhan Ramcharran, Jifu Jiang, Hao Wang, Russell P. Rother, David Gies, Susan J. Faas, Weihua Liu
Publikováno v:
The Journal of Immunology. 179:4451-4463
Ab-mediated rejection (AMR) remains the primary obstacle in presensitized patients following organ transplantation, as it is refractory to anti-T cell therapy and can lead to early graft loss. Complement plays an important role in the process of AMR.
Autor:
Wei-Ping Min, Bertha Garcia, Jacqueline Arp, Weihua Liu, Peta J. O’Connell, Robert Zhong, Nobuyuki Kanai, Siobhan Ramcharran, Xuyan Huang, Hao Wang, Jifu Jiang
Publikováno v:
The Journal of Immunology. 176:3525-3535
We determined whether distinct subclasses of dendritic cells (DC) could polarize cytokine production and regulate the pattern of xenograft rejection. C57BL/6 recipients, transplanted with Lewis rat hearts, exhibited a predominantly CD11c+CD8α+ splen
Publikováno v:
Transplantation Reviews. 19:213-220
The current overwhelming unmet demand for donor organs warrants the search for alternative sources. Pig-to-human xenotransplantation represents a promising approach; however, before this solution can be realized, there are many immunological hurdles