Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Siobhan M. Hughes"'
Autor:
Todd A. Anzelon, Yao Xiao, Gabriel C. Lander, Saikat Chowdhury, Siobhan M. Hughes, Ian J. MacRae
Publikováno v:
Nature
PIWI proteins use PIWI-interacting RNAs (piRNAs) to identify and silence transposable elements and thereby maintain genome integrity between metazoan generations1. The targeting of transposable elements by PIWI has been compared to mRNA target recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d006012a04dd149fd6d39b3cb4f3e5a
https://doi.org/10.1038/s41586-021-03856-x
https://doi.org/10.1038/s41586-021-03856-x
Autor:
Saikat Chowdhury, Siobhan M. Hughes, Ian J. MacRae, Gabriel C. Lander, Yao Xiao, Todd A. Anzelon
SummaryPiwi proteins use PIWI-interacting RNAs (piRNAs) to identify and silence the transposable elements (TEs) pervasively found in animal genomes. The Piwi targeting mechanism is proposed to be similar to targeting by Argonaute proteins, which empl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2ca9180ea53aace715eb9f4873026dd
https://doi.org/10.1101/2020.12.07.413112
https://doi.org/10.1101/2020.12.07.413112
Autor:
Siobhan M. Hughes, Stefania Federico, Valerie E. Pye, Nicola O’Reilly, Samual D. Dick, Peter Cherepanov
Publikováno v:
962.e4
Structure(London, England:1993)
Structure(London, England:1993)
Summary CDC7 is an essential Ser/Thr kinase that acts upon the replicative helicase throughout the S phase of the cell cycle and is activated by DBF4. Here, we present crystal structures of a highly active human CDC7-DBF4 construct. The structures re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60e4e94bce642b8bbd0aecfbb2200c6d
https://doi.org/10.1016/j.str.2020.05.010
https://doi.org/10.1016/j.str.2020.05.010
Autor:
Stephen Matthews, Ai C Wong, Peter Cherepanov, Frédéric Elustondo, Andrea Di Fonzo, Frédéric G Leroux, Siobhan M. Hughes, Ambrosius P. Snijders
Publikováno v:
Nature structuralmolecular biology. 19(11)
CDC7 is a serine/threonine kinase that is essential for the initiation of eukaryotic DNA replication. CDC7 activity is controlled by its activator, DBF4. Here we present crystal structures of human CDC7-DBF4 in complex with a nucleotide or ATP-compet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9de9e3b5215747094b405ad8891c6fa
https://pubmed.ncbi.nlm.nih.gov/23064647
https://pubmed.ncbi.nlm.nih.gov/23064647
Autor:
Siobhan M. Hughes, Patricia Haus, Vanessa Petrucci, Thomas Leiser, Matthew J. Fuchter, S.S. Samlal, Andrew J. P. White, Robert J.K. Wood, Stephen Neidle, Fabrice Turlais, Matthias G. J. Baud, Ai Ching Wong, Lakjaya Buluwela, Franz-Josef Meyer-Almes, Mekala Gunaratnam
Publikováno v:
Journal of medicinal chemistry. 55(4)
Psammaplin A (11c) is a marine metabolite previously reported to be a potent inhibitor of two classes of epigenetic enzymes: histone deacetylases and DNA methyltransferases. The design and synthesis of a focused library based on the psammaplin A core
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746e44178705daaa043dcd345e13d517
https://pubmed.ncbi.nlm.nih.gov/22280363
https://pubmed.ncbi.nlm.nih.gov/22280363
Lens epithelium-derived growth factor (LEDGF) is an important co-factor of human immunodeficiency virus DNA integration; however, its cellular functions are poorly characterized. We now report identification of the Cdc7-activator of S-phase kinase (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bf22841b2149f1c6ebf68c33c78c29f
https://europepmc.org/articles/PMC2804203/
https://europepmc.org/articles/PMC2804203/
Autor:
Peter Cherepanov, Alan Engelman, Ming-Chieh Shun, Paul Kellam, Janet E. Daigle, Nick Vandegraaff, Nidhanapati K. Raghavendra, Siobhan M. Hughes
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their enzymatic activities and chromosomal association. A novel genetic knockout model was established that allowed us for the first time to analyze HIV-1 integration in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac47c3918df1a021003a80c3f10709f
https://europepmc.org/articles/PMC1920171/
https://europepmc.org/articles/PMC1920171/
Autor:
Siobhan M. Hughes, Thomas Leiser, Mekala Gunaratnam, S.S. Samlal, Franz-Josef Meyer-Almes, Fabrice Turlais, Ai Ching Wong, Robert J.K. Wood, Stephen Neidle, Matthias G. J. Baud, Lakjaya Buluwela, Matthew J. Fuchter
Publikováno v:
Molecular Cancer Therapeutics. 10:B166-B166
Naturally isolated products continue to play a significant role in anticancer drug discovery. In line with our interest in small molecule compounds which effect epigenetic gene regulation, we are interested in the structural and biological properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19b546df9e0869de1d670de99e2b238
https://doi.org/10.1158/1535-7163.targ-11-b166
https://doi.org/10.1158/1535-7163.targ-11-b166