Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Siobhan Glavey"'
Autor:
Lyndsey Flanagan, Aisling Coughlan, Nicola Cosgrove, Andrew Roe, Yu Wang, Stephanie Gilmore, Izabela Drozdz, Claire Comerford, Jeremy Ryan, Emma Minihane, Salma Parvin, Michael O’Dwyer, John Quinn, Philip Murphy, Simon Furney, Siobhan Glavey, Tríona Ní Chonghaile, Leukemia Research Foundation, Science Foundation Ireland, Breakthrough Cancer Research
Publikováno v:
Haematologica, Vol 999, Iss 1 (2024)
Multiple Myeloma (MM) is an incurable plasma cell malignancy, that despite an unprecedented increase in overall survival, lacks truly risk-adapted or targeted treatments. A proportion of patients with MM depend on BCL-2 for survival and recently the
Externí odkaz:
https://doaj.org/article/4727a29ad4d04f6192236d546d187e2e
Publikováno v:
Frontiers in Hematology, Vol 3 (2024)
There is growing recognition of the importance of sialylation as a critical post translational modification in cancer. In this article we review the role of increased cell surface sialylation (hypersialylation) in Multiple Myeloma as it relates to ce
Externí odkaz:
https://doaj.org/article/f586f68ca55c465981fdf07ac019f9a2
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11259 (2023)
Extramedullary multiple myeloma (or extramedullary disease, EMD) is an aggressive form of multiple myeloma (MM) that occurs when malignant plasma cells become independent of the bone marrow microenvironment. This may occur alongside MM diagnosis or i
Externí odkaz:
https://doaj.org/article/ecb5c0d11c23427181bbe4f42c549a50
Publikováno v:
Cancers, Vol 15, Iss 9, p 2633 (2023)
Despite significant improvements in the treatment of multiple myeloma (MM), it remains mostly incurable, highlighting a need for new therapeutic approaches. Patients with high-risk disease characteristics have a particularly poor prognosis and limite
Externí odkaz:
https://doaj.org/article/68613cbbb1864d4b89e0fb8f57ba654d
Publikováno v:
Cancers, Vol 15, Iss 6, p 1819 (2023)
Multiple myeloma (MM) is the second most common haematological neoplasm of adults in the Western world. Overall survival has doubled since the advent of proteosome inhibitors (PIs), immunomodulatory agents (IMiDs), and monoclonal antibodies. However,
Externí odkaz:
https://doaj.org/article/a69ffa9c00234e599605e73a45d67c39
Autor:
Amy P Worrall, Claire Kelly, Aine O'Neill, Murray O'Doherty, Eoin Kelleher, Anne Marie Cushen, Cora McNally, Samuel McConkey, Siobhan Glavey, Michelle Lavin, Eoghan de Barra
Publikováno v:
JMIR Formative Research, Vol 5, Iss 8, p e21817 (2021)
BackgroundEarly evidence of COVID-19–associated coagulopathy disseminated rapidly online during the first months of 2020, followed by clinical debate about how best to manage thrombotic risks in these patients. The rapid online spread of case repor
Externí odkaz:
https://doaj.org/article/8d4772766e0149a189eed5d852c02e2e
Publikováno v:
eJHaem, Vol 1, Iss 1, Pp 312-314 (2020)
Externí odkaz:
https://doaj.org/article/705a3e0b78604ec8932b1b0642e2e797
Autor:
Aldo M. Roccaro, Yuji Mishima, Antonio Sacco, Michele Moschetta, Yu-Tzu Tai, Jiantao Shi, Yong Zhang, Michaela R. Reagan, Daisy Huynh, Yawara Kawano, Ilyas Sahin, Marco Chiarini, Salomon Manier, Michele Cea, Yosra Aljawai, Siobhan Glavey, Elizabeth Morgan, Chin Pan, Franziska Michor, Pina Cardarelli, Michelle Kuhne, Irene M. Ghobrial
Publikováno v:
Cell Reports, Vol 12, Iss 4, Pp 622-635 (2015)
Extra-medullary disease (EMD) in multiple myeloma (MM) is associated with poor prognosis and resistance to chemotherapy. However, molecular alterations that lead to EMD have not been well defined. We developed bone marrow (BM)- and EMD-prone MM synge
Externí odkaz:
https://doaj.org/article/c17cc3846a7d44b0a97692c30372fb41
Autor:
Wenjing Zhang, Yaoyu E Wang, Yu Zhang, Xavier Leleu, Michaela Reagan, Yong Zhang, Yuji Mishima, Siobhan Glavey, Salomon Manier, Antonio Sacco, Bo Jiang, Aldo M Roccaro, Irene M Ghobrial
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110973 (2014)
Epigenetic changes frequently occur during tumorigenesis and DNA hypermethylation may account for the inactivation of tumor suppressor genes in cancer cells. Studies in Multiple Myeloma (MM) have shown variable DNA methylation patterns with focal hyp
Externí odkaz:
https://doaj.org/article/cf08cdb52ee0441a9a83c818eadb3a8d
Autor:
Claire Comerford, Sukhraj Pal Singh Dhami, Philip Murphy, Sean Patmore, Soracha Ward, Nadiya Pushkar, Ulrich Budde, Ellie Karampini, James S. O'Donnell, Siobhan Glavey, John Quinn, Jamie M. O'Sullivan
Publikováno v:
Thrombosis Research. 226:136-140