Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Siobhan Cunniffe"'
Autor:
Anna M Rose, Tomas Goncalves, Siobhan Cunniffe, Helene E B Geiller, Thomas Kent, Sam Shepherd, Malitha Ratnaweera, Roderick J O’Sullivan, Richard J Gibbons, David Clynes
Publikováno v:
Nucleic Acids Research.
Telomere maintenance is a hallmark of malignant cells and allows cancers to divide indefinitely. In some cancers, this is achieved through the alternative lengthening of telomeres (ALT) pathway. Whilst loss of ATRX is a near universal feature of ALT-
Autor:
Thomas Kent, Sam Shepherd, Sangwoo Kim, Richard J. Gibbons, David Clynes, Tomas Goncalves, Siobhan Cunniffe, Tim Humphrey
A key requisite for indefinite growth of cancer cells is the ability to continuously elongate telomeres to circumvent the onset of senescence or apoptosis. In approximately 10 – 15% of cancers this is achieved through the Alternative Lengthening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f3ae17a8c1751e0ac6337acbcd54734
https://doi.org/10.21203/rs.3.rs-362334/v1
https://doi.org/10.21203/rs.3.rs-362334/v1
Autor:
Xin Chen, Dengfu Yao, Bruno Vaz, Samuel Hume, Siobhan Cunniffe, Mattia Poletto, Grigory L. Dianov, Kristijan Ramadan, Arnaud J. Legrand
Publikováno v:
Cellular Oncology (Dordrecht)
Background To deliver efficacious personalised cancer treatment, it is essential to characterise the cellular metabolism as well as the genetic stability of individual tumours. In this study, we describe a new axis between DNA repair and detoxificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3bb074982b870df38c595dd8f5dd0d
https://doi.org/10.1007/s13402-018-0390-8
https://doi.org/10.1007/s13402-018-0390-8
Publikováno v:
Mutation Research
Highlights • A dL lesion is not repaired as effectively as an AP site. • The repair of a cluster with dL and 8-oxodGuo lesions is compromised. • Delayed repair of the cluster leads to an increase in mutation frequency.
A signature of ioniz
A signature of ioniz
Ionizing radiation induces clustered DNA damaged sites, defined as two or more lesions formed within one or two helical turns of the DNA through passage of a single radiation track. It is now established that clustered DNA damage sites are found in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75012f2c78b7c80e45cd4d8d93504278
https://ora.ox.ac.uk/objects/uuid:bc729068-e75a-4ff2-b42c-6954c7f42747
https://ora.ox.ac.uk/objects/uuid:bc729068-e75a-4ff2-b42c-6954c7f42747
To characterize the DNA damage induced by K-shell ionization of phosphorus atom in DNA backbone on the level of hydration, the yields of DNA strand breaks and base lesions arising from the interaction of ultrasoft X rays with energies around the phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f4b49e5182fbb7bab17ceafb3661ae
https://doi.org/10.1667/rr1609.1
https://doi.org/10.1667/rr1609.1
Publikováno v:
Nucleic Acids Research
Localized clustering of damage is a hallmark of certain DNA-damaging agents, particularly ionizing radiation. The potential for genetic change arising from the effects of clustered damage sites containing combinations of AP sites, 8-oxo-7,8-dihydrogu
Publikováno v:
Biochemistry. 43:11017-11026
Ionizing radiation induces clustered DNA damage sites which have been shown to challenge the repair mechanism(s) of the cell. Evidence demonstrating that base excision repair is compromised during the repair of an abasic (AP) site present within a cl
Publikováno v:
International Journal of Radiation Biology
Purpose Ionizing radiation induces DNA damage, some of which are present in clusters, defined as two or more lesions within one to two helical turns of DNA by passage of a single radiation track. These clusters are thought to contribute to the detrim
Publikováno v:
Radiation research. 172(5)
Ionizing radiation can induce clustered DNA damage (two or more lesions formed within one to two helical turns of DNA by passage of a single ionization track). Using oligonucleotide constructs containing clustered DNA lesions at defined positions, ev