Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Siobhan, O'Brien"'
Autor:
Libby Brown, Aldrin V. Vidal, Ana Laura Dias, Tiago Rodrigues, Anna Sigurdardottir, Toby Journeaux, Siobhan O’Brien, Thomas V. Murray, Peter Ravn, Monika Papworth, Gonçalo J. L. Bernardes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Cyclization provides a general strategy for improving the proteolytic stability, cell membrane permeability and target binding affinity of peptides. Insertion of a stable, non-reducible linker into a disulphide bond is a commonly used approa
Externí odkaz:
https://doaj.org/article/0dbb71bb3e424358b642bfa50634c304
Autor:
Kristina Turner, Siobhan O’Brien, Helena Wallström, Katarina Samuelsson, Sirkka-Liisa Marjatta Uusimäki
Publikováno v:
International Journal of Educational Technology in Higher Education, Vol 20, Iss 1, Pp 1-17 (2023)
Abstract This article reports on a study analysing changes in the use of digital technologies and working from home during the COVID-19 crisis and the impact of these changes on the wellbeing of five female university lecturers from Australia and Swe
Externí odkaz:
https://doaj.org/article/503444011d7e44ab8e7fa78fc531c292
Autor:
Siobhan O’Brien, Alice H. Berger
Publikováno v:
Cell Reports: Methods, Vol 3, Iss 10, Pp 100618- (2023)
Publishing in Science, Girish and colleagues achieve chromosome-level genome editing to reveal a requirement for aneuploidy in breast and melanoma cancers. Authors developed and leveraged ReDACT (restoring disomy in aneuploid cells using CRISPR targe
Externí odkaz:
https://doaj.org/article/a5297b29c490486a9eea025f7902fe81
Publikováno v:
F1000Research, Vol 11 (2022)
The respiratory tract is a compartmentalised and heterogenous environment. The nasopharynx and sinuses of the upper airways have distinct properties from the lungs and these differences may shape bacterial adaptation and evolution. Upper airway niche
Externí odkaz:
https://doaj.org/article/1f11b0ff41484b5da4e2637771e27865
Autor:
Matt J Barter, Kathleen Cheung, Julia Falk, Andreas C Panagiotopoulos, Caitlin Cosimini, Siobhan O’Brien, Karina Teja-Putri, Graham Neill, David J Deehan, David A. Young
Publikováno v:
Epigenetics, Vol 16, Iss 1, Pp 106-119 (2021)
Dynamic modifications of chromatin allow rapid access of the gene regulatory machinery to condensed genomic regions facilitating subsequent gene expression. Inflammatory cytokine stimulation of cells can cause rapid gene expression changes through di
Externí odkaz:
https://doaj.org/article/f3384607721b41a5a198673cf0f7c3ea
Publikováno v:
Evolution Letters, Vol 4, Iss 2, Pp 155-163 (2020)
Abstract Heterogeneity in resources is a ubiquitous feature of natural landscapes affecting many aspects of biology. However, the effect of environmental heterogeneity on the evolution of cooperation has been less well studied. Here, using a mixture
Externí odkaz:
https://doaj.org/article/26310b81de094ec788ea08448e4d334d
Autor:
Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sørensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes
Publikováno v:
Molecular Metabolism, Vol 55, Iss , Pp 101392- (2022)
Objective: Obesity-linked type 2 diabetes (T2D) is a worldwide health concern and many novel approaches are being considered for its treatment and subsequent prevention of serious comorbidities. Co-administration of glucagon like peptide 1 (GLP-1) an
Externí odkaz:
https://doaj.org/article/b325ef86371a42baa07ae1549ba9e3b0
Publikováno v:
International Journal of Integrated Care, Vol 19, Iss 4 (2019)
Introduction: Socially excluded individuals have higher morbidity and mortality, use a disproportionate amount of healthcare resources and generate a large volume of potentially preventable healthcare and other costs compared to more privileged indiv
Externí odkaz:
https://doaj.org/article/7ca7dddd4c43473db22e4be3c67b18fb
Autor:
Yuyong Tao, Monika Mis, Levi Blazer, Mart Ustav Jnr, Zachary Steinhart, Rony Chidiac, Elli Kubarakos, Siobhan O'Brien, Xiaomei Wang, Nick Jarvik, Nish Patel, Jarrett Adams, Jason Moffat, Stephane Angers, Sachdev S Sidhu
Publikováno v:
eLife, Vol 8 (2019)
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6. The hydrophobicity of Wnt proteins has complicated their purification and limited the
Externí odkaz:
https://doaj.org/article/0536d3ce52994e848a42a3b00dc17aa9
Publikováno v:
International Journal of Mentoring and Coaching in Education, 2016, Vol. 5, Issue 2, pp. 144-157.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/IJMCE-10-2015-0031