Multi‐phase multi‐layer mechanistic dermal absorption (MPML MechDermA) model to predict local and systemic exposure of drug products applied on skin

Autor: Nikunjkumar Patel, James F. Clarke, Farzaneh Salem, Tariq Abdulla, Frederico Martins, Sumit Arora, Eleftheria Tsakalozou, Arran Hodgkinson, Omid Arjmandi‐Tash, Sinziana Cristea, Priyanka Ghosh, Khondoker Alam, Sam G. Raney, Masoud Jamei, Sebastian Polak

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 1060-1084 (2022)

Abstract Physiologically‐based pharmacokinetic models combine knowledge about physiology, drug product properties, such as physicochemical parameters, absorption, distribution, metabolism, excretion characteristics, formulation attributes, and tria

Externí odkaz: https://doaj.org/article/afd2ab177bf7434a8488d0d0e8d82e93

The Predictive Value of Glomerular Filtration Rate-Based Scaling of Pediatric Clearance and Doses for Drugs Eliminated by Glomerular Filtration with Varying Protein-Binding Properties

Autor: Catherijne A. J. Knibbe, Karel Allegaert, Sinziana Cristea, Elke H. J. Krekels

Publikováno v: Clinical Pharmacokinetics, 59(10), 1291-1301. Adis
Clinical Pharmacokinetics

Introduction For drugs eliminated by glomerular filtration (GF), clearance (CL) is determined by GF rate (GFR) and the unbound fraction of the drug. When predicting CL of GF-eliminated drugs in children, instead of physiologically based pharmacokinet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68dc2357abce1e3e6ec1c202d8e46621
https://pure.eur.nl/en/publications/f0a8349c-f349-412d-a1c5-dc016e317d43

Larger Dose Reductions of Vancomycin Required in Neonates with Patent Ductus Arteriosus Receiving Indomethacin versus Ibuprofen

Autor: Sinziana Cristea, Karel Allegaert, Amílcar Falcão, Anne Smits, F. Falcao, Ranil de Silva, Catherijne A. J. Knibbe, Ehj Krekels

Publikováno v: Antimicrobial Agents & Chemotherapy, 63(8):e00853-19. American Society for Microbiology
Antimicrobial Agents and Chemotherapy, 63(8), e00853

Ibuprofen and indomethacin are commonly used to induce ductus arteriosus closure in preterm neonates. Our group previously reported that ibuprofen decreased vancomycin clearance by 16%. In this study, we quantified the impact of indomethacin coadmini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237d9b9135f8846db576107192a4425d
https://lirias.kuleuven.be/handle/123456789/638388

Amikacin Pharmacokinetics To Optimize Dosing in Neonates with Perinatal Asphyxia Treated with Hypothermia

Autor: Sinziana Cristea, Catherijne A. J. Knibbe, Anne Smits, Karel Allegaert, Mirjam M. van Weissenbruch, Aida Kulo, Elke H. J. Krekels

Publikováno v: Antimicrobial Agents & Chemotherapy, 61(12):e01282-17. American Society for Microbiology
Cristea, S, Smits, A, Kulo, A, Knibbe, C A J, Van Weissenbruch, M, Krekels, E H J & Allegaert, K 2017, ' Amikacin pharmacokinetics to optimize dosing in neonates with perinatal asphyxia treated with hypothermia ', Antimicrobial Agents and Chemotherapy, vol. 61, no. 12, e01282 . https://doi.org/10.1128/AAC.01282-17
Antimicrobial Agents and Chemotherapy, 61(12):e01282. American Society for Microbiology

Aminoglycosides pharmacokinetics (PK) is expected to change in neonates with perinatal asphyxia treated with therapeutic hypothermia (PATH). Several amikacin dosing guidelines have been proposed to treat neonates with (suspected) septicemia, however,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bffb2557d59ec58bb08f56744de5846
https://pure.eur.nl/en/publications/122725f0-c9ef-4db1-909d-1333d1317090