The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection.

Autor: Quintana, Juan F.^1,2,3 (AUTHOR) juan.quintana@glasgow.ac.uk, Sinton, Matthew C.^1,4 (AUTHOR), Chandrasegaran, Praveena³ (AUTHOR), Kumar Dubey, Lalit⁵ (AUTHOR), Ogunsola, John³ (AUTHOR), Al Samman, Moumen³ (AUTHOR), Haley, Michael^1,2 (AUTHOR), McConnell, Gail⁶ (AUTHOR), Kuispond Swar, Nono-Raymond⁷ (AUTHOR), Ngoyi, Dieudonné Mumba⁷ (AUTHOR), Bending, David⁸ (AUTHOR), de Lecea, Luis⁹ (AUTHOR), MacLeod, Annette³ (AUTHOR), Mabbott, Neil A.¹⁰ (AUTHOR)

Publikováno v: PLoS Biology. 11/20/2023, Vol. 21 Issue 11, p1-45. 45p.

Integrated spatial and single cell transcriptomic analyses reveal a critical role for V6  T cells in the control of skin inflammation during infection

Autor: Quintana, Juan F, Sinton, Matthew C, Chandrasegaran, Praveena, Nabilla Lestari, Agatha, Cheaib, Bachar, Ogunsola, John, Heslop, Rhiannon, Ngoyi, Dieudonne Mumba, Kuispond Star, Nono-Raymond, Cooper, Anneli, Coffelt, Seth B., MacLeod, Annette

African trypanosome parasites colonise the skin in a process important for parasite transmission. However, how the skin responses to trypanosome infection remain unresolved. Here, using a combination of spatial and single cell transcriptomics, couple

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The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection:Functional characterisation of the murine meninges during chronic infections

Autor: Quintana, Juan F., Sinton, Matthew C., Chandrasegaran, Praveena, Dubey , Lalit Kumar, Ogunsola, John, Samman, Moumen Al, Haley, Michael J, McConnell, Gail, Swar, Nono-Raymond Kuispond, Ngoyi, Dieudonne Mumba, Mabbott, Neil, MacLeod, Annette

Publikováno v: Quintana, J F, Sinton, M C, Chandrasegaran, P, Dubey, L K, Ogunsola, J, Samman, M A, Haley, M J, McConnell, G, Swar, N-R K, Ngoyi, D M, Mabbott, N & MacLeod, A 2023 ' The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection : Functional characterisation of the murine meninges during chronic infections ' bioRxiv . https://doi.org/10.1101/2023.04.30.538710

The meningeal space is an important structure in the brain borders, which provides immunosurveillance for the central nervous system, but the impact of infections on the meningeal immune landscape is far from being fully understood. The extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::4db185ef88c22334c8daec6d12d3d39f
https://hdl.handle.net/20.500.11820/e2f0043a-4910-4132-beda-39ea6bc3b2cb

IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection.

Autor: Sinton, Matthew C., Chandrasegaran, Praveena R. G., Capewell, Paul, Cooper, Anneli, Girard, Alex, Ogunsola, John, Perona-Wright, Georgia, M Ngoyi, Dieudonné, Kuispond, Nono, Bucheton, Bruno, Camara, Mamadou, Kajimura, Shingo, Bénézech, Cécile, Mabbott, Neil A., MacLeod, Annette, Quintana, Juan F.

Publikováno v: Nature Communications; 11/3/2023, Vol. 14 Issue 1, p1-21, 21p