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Orally bioavailable STING antagonist synthesized via multi-component Povarov-Doebner type reaction.

Autor: Owusu KB; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. hsintim@purdue.edu.; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, USA., Samal J; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. hsintim@purdue.edu.; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, USA., Hernandez DE; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. hsintim@purdue.edu., Sintim HO; Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907, USA. hsintim@purdue.edu.; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, USA.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, IN, 47907, USA.

Publikováno v: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Oct 15; Vol. 60 (83), pp. 11932-11935. Date of Electronic Publication: 2024 Oct 15.

Borrelia burgdorferi Secretes c-di-AMP as an Extracellular Pathogen-Associated Molecular Pattern to Elicit Type I Interferon Responses in Mammalian Hosts.

Autor: Priya R; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Ye M; Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China., Raghunanadanan S; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Liu Q; National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.; Wenzhou key laboratory of sanitary microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical UniversityDepartment of Chemistry, 560 Oval Drive, West Lafayette, IN 47907, USA., Li W; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Yu Q; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Lou Y; Wenzhou key laboratory of sanitary microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical UniversityDepartment of Chemistry, 560 Oval Drive, West Lafayette, IN 47907, USA., Sintim HO; Institute for Drug Discovery, Purdue University, 720 Clinic Drive, West Lafayette, IN 47907, USA.; Purdue Institute of Inflammation, Immunology, and Infectious Disease, West Lafayette, IN 47907, USA.; James Tarpo Jr. and Margaret Tarpo Department of Chemistry, Purdue University, 560 Oval Drive, IN 47907, USA., Yang XF; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 20. Date of Electronic Publication: 2024 Aug 20.

Alkynyl nicotinamides show antileukemic activity in drug-resistant acute myeloid leukemia.

Autor: Ramdas B; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Dayal N; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Pandey R; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Larocque E; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Kanumuri R; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Pasupuleti SK; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Liu S; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Kanellopoulou C; KinaRx, Inc, Rockville, Maryland, USA., Chu EFY; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Mohallem R; Department of Comparative Pathobiology., Virani S; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA., Chopra G; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.; Tyler Trent Pediatric Cancer Research Center, Purdue University Institute for Cancer Research.; Department of Computer Science (by courtesy).; Regenstrief Center for Healthcare Engineering.; Purdue Institute for Drug Discovery, and., Aryal UK; Department of Comparative Pathobiology.; Purdue Proteomics Facility, Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, USA., Lapidus R; KinaRx, Inc, Rockville, Maryland, USA.; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA., Wan J; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Emadi A; KinaRx, Inc, Rockville, Maryland, USA.; University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore, Maryland, USA., Haneline LS; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA., Holtsberg FW; KinaRx, Inc, Rockville, Maryland, USA., Aman MJ; KinaRx, Inc, Rockville, Maryland, USA., Sintim HO; Department of Chemistry, Purdue University, West Lafayette, Indiana, USA.; KinaRx, Inc, Rockville, Maryland, USA.; Tyler Trent Pediatric Cancer Research Center, Purdue University Institute for Cancer Research., Kapur R; Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Microbiology and Immunology, and.; Department of Molecular Biology and Biochemistry, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 Jun 17; Vol. 134 (12). Date of Electronic Publication: 2024 Jun 17.