Výsledky vyhledávání - "Sinthyia Ahmed"

Akademický článek

Investigation of the impact of nonsynonymous mutations on thyroid peroxidase dimer.

Autor: Mst Noorjahan Begum, Rumana Mahtarin, Sinthyia Ahmed, Imrul Shahriar, Shekh Rezwan Hossain, Md Waseque Mia, Syed Saleheen Qadri, Firdausi Qadri, Kaiissar Mannoor, Sharif Akhteruzzaman

Publikováno v: PLoS ONE, Vol 18, Iss 9, p e0291386 (2023)

Congenital hypothyroidism is one of the most common preventable endocrine disorders associated with thyroid dysgenesis or dyshormonogenesis. Thyroid peroxidase (TPO) gene defect is mainly responsible for dyshormonogenesis; a defect in the thyroid hor

Externí odkaz: https://doaj.org/article/eb14f6e5b78c4edf8ebc49654215a74b

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Akademický článek

Molecular modelling approaches predicted 1,2,3-triazolyl ester of ketorolac (15K) to be a novel allosteric modulator of the oncogenic kinase PAK1

Autor: Md Shahinozzaman, Sinthyia Ahmed, Rashiduzzaman Emran, Shinkichi Tawata

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)

Abstract P21-activated kinases (PAKs) are serine/threonine protein kinase which have six different isoforms (PAK1–6). Of those, PAK1 is overexpressed in many cancers and considered to be a major chemotherapeutic target. Most of the developed PAK1 i

Externí odkaz: https://doaj.org/article/97627965dec141f385e331f0e5a399ac

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Akademický článek

Isolation and In Silico Prediction of Potential Drug-like Compounds with a New Dimeric Prenylated Quinolone Alkaloid from Zanthoxylum rhetsa (Roxb.) Root Extracts Targeted against SARS-CoV-2 (Mpro)

Autor: Fatema Tuz Zohora, A. T. M. Zafrul Azam, Sinthyia Ahmed, Khondaker Miraz Rahman, Mohammad A. Halim, Md. Rafi Anwar, Md. Hossain Sohrab, Fatema Tabassum, Choudhury Mahmood Hasan, Monira Ahsan

Publikováno v: Molecules, Vol 27, Iss 23, p 8191 (2022)

A new dimeric prenylated quinolone alkaloid, named 2,11-didemethoxy-vepridimerine A, was isolated from the root bark of Zanthoxylum rhetsa, together with twelve known compounds. The structure of the new compound was elucidated on the basis of spectro

Externí odkaz: https://doaj.org/article/cceaae2c32c84ac58d9f42e199163a12

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Molecular Investigation of TSHR gene in Bangladeshi Congenital Hypothyroid patients

Autor: Mst. Noorjahan Begum, Rumana Mahtarin, Md Tarikul Islam, Sinthyia Ahmed, Tasnia Kawsar Konika, Kaiissar Mannoor, Sharif Akhteruzzaman, Firdausi Qadri

The disorder of thyroid gland development or thyroid dysgenesis (TH) accounts for 80-85% cases of congenital hypothyroidism (CH). Hence, the understanding of molecular etiology of TH is prerequisite. Mutations in TSHR gene is mostly associated with t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a37aa6dcd92bae356b14a10db4870b6
https://doi.org/10.1101/2023.02.20.529210

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Molecular modelling approaches predicted 1,2,3-triazolyl ester of ketorolac (15K) to be a novel allosteric modulator of the oncogenic kinase PAK1

Autor: Shahinozzaman, Sinthyia Ahmed, Shinkichi Tawata, Rashiduzzaman Emran

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports

P21-activated kinases (PAKs) are serine/threonine protein kinase which have six different isoforms (PAK1–6). Of those, PAK1 is overexpressed in many cancers and considered to be a major chemotherapeutic target. Most of the developed PAK1 inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c8fc0d9973944ead24bcead45ce164
https://doaj.org/article/97627965dec141f385e331f0e5a399ac

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Isolation and In silico prediction of potential drug-like compounds with a new dimeric prenylated quinolone alkaloid from Zanthoxylum rhetsa (Roxb.) root extracts targeted against SARS-CoV-2 (Mpro)

Autor: Fatema -Tuz- Zohora, Sinthyia Ahmed, Khondaker Miraz Rahman, Mohammad A. Halim, Md. Rafi Anwar, Md. Hossain Sohrab, Fatema Tabassum, Choudhury Mahmood Hasan, Monira Ahsan

A new dimeric prenylated quinolone alkaloid, named 2,11-didemethoxy-vepridimerine A, was isolated from the root bark of Zanthoxylum rhetsa, together with thirteen known compounds. The structure of the new compound was elucidated on the basis of spect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::92a5747abb46da21fb86187a74b2ca4c
https://doi.org/10.21203/rs.3.rs-1678790/v1

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Investigating the binding affinity, interaction, and structure-activity-relationship of 76 prescription antiviral drugs targeting RdRp and Mpro of SARS-CoV-2

Autor: R. Islam, Shaila Akter, Nayeem Hossain, Ackas Ali, Rimon Parves, Mohammad A. Halim, Sayeda Samina Ahmed, Rumana Mahtarin, Mossammad Umme Chand Sultana, M. Obayed Ullah, Abdulla Al Mamun, Sinthyia Ahmed, Shamiul Islam

Publikováno v: Journal of Biomolecular Structure & Dynamics
article-version (VoR) Version of Record
Journal of Biomolecular Structure and Dynamics

SARS-CoV-2 virus outbreak poses a major threat to humans worldwide due to its highly contagious nature. In this study, molecular docking, molecular dynamics, and structure-activity relationship are employed to assess the binding affinity and interact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ef71e185d2127dc663e9ec80bd923d
https://doi.org/10.1080/07391102.2020.1796804

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Virtual screening, molecular dynamics, density functional theory and quantitative structure activity relationship studies to design peroxisome proliferator-activated receptor-γ agonists as anti-diabetic drugs

Autor: Mohammad A. Halim, Sayo O. Fakayode, Nadia Afrin, Sinthyia Ahmed, Nazrul Islam, Shahinozzaman

Publikováno v: Journal of Biomolecular Structure and Dynamics. 39:728-742

Type 2 diabetes (T2D) is generally characterized by elevated blood glucose levels, insulin resistance, and relative lack of insulin; however, insulin resistance is the predominant risk factor. Hence, the use of insulin sensitizer drugs to increase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85832a8a3593ce3536e3e9a4fe841d31
https://doi.org/10.1080/07391102.2020.1714482

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Remdesivir analogs against SARS-CoV-2 RNA-dependent RNA polymerase

Autor: Sinthyia Ahmed, Sayeda Samina Ahmed, Rumana Mahtarin, Abdulla Al Mamun, Shamiul Islam, Ackas Ali, Susmita Das

Publikováno v: Journal of biomolecular structuredynamics. 40(21)

The COVID-19 pandemic has already taken many lives but is still continuing its spread and exerting jeopardizing effects. This study is aimed to find the most potent ligands from 703 analogs of remdesivir against RNA-dependent RNA polymerase (RdRp) pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5a6f991cfd3b880d4c0111ddf112cc
https://pubmed.ncbi.nlm.nih.gov/34315339

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Designing potent inhibitors against the multidrug resistance P-glycoprotein

Autor: Mohammad A. Halim, Md. Rimon Parves, Sayo O. Fakayode, Md. Arif Khan, Lamiya Tabussum, Shafi Mahmud, Md. Ackas Ali, Md. Jahirul Islam, Sinthyia Ahmed

Publikováno v: Journal of biomolecular structuredynamics. 40(19)

The multidrug transporter P-glycoprotein is an ATP binding cassette (ABC) exporter responsible for resistance to tumor cells during chemotherapy. This study was designed with computational approaches aimed at identifying the best potent inhibitors of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333e4b8d7eb1141f7b5692315d657492
https://pubmed.ncbi.nlm.nih.gov/34060432

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