Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

Autor: Galetzka, Danuta, B��ck, Julia, Wagner, Lukas, Dittrich, Marcus, Sinizyn, Olesja, Ludwig, Marco, Rossmann, Heidi, Spix, Claudia, Radsak, Markus, Scholz-Kreisel, Peter, Mirsch, Johanna, Linke, Matthias, Brenner, Walburgis, Marron, Manuela, Poplawski, Alicia, Haaf, Thomas, Schmidberger, Heinz, Prawitt, Dirk

Publikováno v: EXCLI journal, 21:117-143

Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. However, risk factors might trigger the oncogenic transformation of cells. Among other regulatory signals, hypermethylation of RAD9A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b01e9716f2fb0e3655b0151dd488a0d
https://repository.publisso.de/resource/frl:6433666

Molecular karyotyping and gene expression analysis in childhood cancer patients

Autor: Kartal Nergiz, Prawitt Dirk, Müller Tobias, Mirsch Johanna, Poplawski Alicia, Rapp Steffen, Chorzempa Heather, Sinizyn Olesja, Galetzka Danuta, Spix Claudia, Rossmann Heidi, Müller Christian, Scholz-Kreisel Peter, Endres Miriam, Haaf Thomas, Hankeln Thomas, Zeller Tanja, Schmidberger Heinz, Dittrich Marcus, Marron Manuela

Publikováno v: Journal of Molecular Medicine (Berlin, Germany)
Journal of molecular medicine, 98:1107-1123

Abstract The genetic etiology of sporadic childhood cancer cases remains unclear. We recruited a cohort of 20 patients who survived a childhood malignancy and then developed a second primary cancer (2N), and 20 carefully matched patients who survived

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e9200189adc0b7c9e555d052b1b3837

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation.

Autor: Galetzka D; Department of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany., Böck J; Institute of Human Genetics, Julius Maximilians University, Würzburg, Germany.; Institute of Pathology, Julius Maximilians University, Würzburg, Germany., Wagner L; Center for Pediatrics and Adolescent Medicine, University Medical Centre, Mainz, Germany., Dittrich M; Bioinformatics Department, Julius Maximilians University, Würzburg, Germany., Sinizyn O; Department of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany., Ludwig M; DRK Medical Centre, Alzey, Germany., Rossmann H; Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre, Mainz, Germany., Spix C; Division of Childhood Cancer Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Mainz, Germany., Radsak M; Department of Hematology, University Medical Centre, Mainz, Germany., Scholz-Kreisel P; Federal Office of Radiation, Neuherberg, Germany., Mirsch J; Radiation Biology and DNA Repair, Technical University of Darmstadt, Germany., Linke M; Institute of Human Genetics, University Medical Centre, Mainz, Germany., Brenner W; Department of Obstetrics and Women's Health, University Medical Centre, Mainz, Germany., Marron M; Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany., Poplawski A; Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Mainz, Germany., Haaf T; Institute of Human Genetics, Julius Maximilians University, Würzburg, Germany., Schmidberger H; Department of Radiation Oncology and Radiation Therapy, University Medical Centre, Mainz, Germany., Prawitt D; Center for Pediatrics and Adolescent Medicine, University Medical Centre, Mainz, Germany.

Publikováno v: EXCLI journal [EXCLI J] 2022 Jan 07; Vol. 21, pp. 117-143. Date of Electronic Publication: 2022 Jan 07 (Print Publication: 2022).