Zobrazeno 1 - 10
of 250
pro vyhledávání: '"Sinisa Savic"'
Autor:
Paula David, Saptarshi Sinha, Khizer Iqbal, Gabriele De Marco, Sahar Taheri, Ella McLaren, Sheetal Maisuria, Gururaj Arumugakani, Zoe Ash, Catrin Buckley, Lauren Coles, Chamila Hettiarachchi, Emma Payne, Sinisa Savic, Gayle Smithson, Maria Slade, Rahul Shah, Helena Marzo-Ortega, Mansoor Keen, Catherine Lawson, Joanna Mclorinan, Sharmin Nizam, Hanu Reddy, Omer Sharif, Shabina Sultan, Gui Tran, Mark Wood, Samuel Wood, Pradipta Ghosh, Dennis McGonagle
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105136- (2024)
Summary: Background: Anti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5+-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 is an RNA sensor and a key pattern rec
Externí odkaz:
https://doaj.org/article/1889cb427e554efead61e6d652dc683d
Autor:
Heledd H Jarosz-Griffiths, Lindsey Gillgrass, Laura R Caley, Giulia Spoletini, Ian J Clifton, Christine Etherington, Sinisa Savic, Michael F McDermott, Daniel Peckham
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0304555 (2024)
Inflammation is a key driver in the pathogenesis of cystic fibrosis (CF). We assessed the effectiveness of elexacaftor/tezacaftor/ivacaftor (ETI) therapy on downregulating systemic and immune cell-derived inflammatory cytokines. We also monitored the
Externí odkaz:
https://doaj.org/article/caa59c7e9d2246b8a30553c4cecf4594
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 6, p 1717 (2024)
Common Variable Immunodeficiency (CVID) is a heterogeneous primary immunodeficiency disorder characterised by impaired antibody production, leading to recurrent infections and an increased susceptibility to viral pathogens. This literature review aim
Externí odkaz:
https://doaj.org/article/e90f82b38dc6456891b18c17a5eea401
Autor:
Sarah Tonkin-Crine, Sinisa Savic, Robert M West, Ly-Mee Yu, Sue Pavitt, Ushma Galal, Christopher C Butler, Marta Wanat, Johanna Cook, Bethany Shinkins, Mina Davoudianfar, Emily Bongard, Philip Howard, Marta Santillo, Jenny Boards, Jonathan A T Sandoe, Ruben Mujica-Mota, Razan Saman, Kelsey Fiona Armitage, Catherine E Porter, Shadia Ahmed, Kate Corfield
Publikováno v:
BMJ Open, Vol 13, Iss 9 (2023)
Introduction Incorrect penicillin allergy records are recognised as an important barrier to the safe treatment of infection and affect an estimated 2.7 million people in England. Penicillin allergy records are associated with worse health outcome and
Externí odkaz:
https://doaj.org/article/fb3989c207db43b5b4991134f8fc2fb5
Autor:
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James Poulter, David G. Kent, Sinisa Savic, on behalf of the ImmunAID consortium
Publikováno v:
HemaSphere, Vol 7, Iss 8, p e934 (2023)
Externí odkaz:
https://doaj.org/article/d91f072a395a4835b1c491213ce371f7
Autor:
Adrian M. Shields, Susan Tadros, Adam Al-Hakim, Jeremy M. Nell, Me Me Nay Lin, Michele Chan, Sarah Goddard, John Dempster, Magdalena Dziadzio, Smita Y. Patel, Shuayb Elkalifa, Aarnoud Huissoon, Christopher J. A. Duncan, Archana Herwadkar, Sujoy Khan, Claire Bethune, Suzanne Elcombe, James Thaventhiran, Paul Klenerman, David M. Lowe, Sinisa Savic, Siobhan O. Burns, Alex G. Richter
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundIndividuals with primary and secondary immunodeficiency (PID/SID) were shown to be at risk of poor outcomes during the early stages of the SARS-CoV-2 pandemic. SARS-CoV-2 vaccines demonstrate reduced immunogenicity in these patients.Objecti
Externí odkaz:
https://doaj.org/article/49c785e79b714896b5548d584cac175b
Autor:
Marta Wanat, Sibyl Anthierens, Christopher C. Butler, Louise Savic, Sinisa Savic, Sue H. Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine
Publikováno v:
BMC Family Practice, Vol 22, Iss 1, Pp 1-9 (2021)
Abstract Background Six percent of patients are allergic to penicillin according to their medical records. While this designation protects a small number of truly allergic patients from serious reactions, those who are incorrectly labelled may be den
Externí odkaz:
https://doaj.org/article/6241ca20f770475f824acbca229348e5
Autor:
Adrian M. Shields, Sian E. Faustini, Harriet J. Hill, Saly Al-Taei, Chloe Tanner, Fiona Ashford, Sarita Workman, Fernando Moreira, Nisha Verma, Hollie Wagg, Gail Heritage, Naomi Campton, Zania Stamataki, Mark T. Drayson, Paul Klenerman, James E. D. Thaventhiran, Shuayb Elkhalifa, Sarah Goddard, Sarah Johnston, Aarnoud Huissoon, Claire Bethune, Suzanne Elcombe, David M. Lowe, Smita Y. Patel, Sinisa Savic, Alex G. Richter, Siobhan O. Burns, the COV-AD consortium, Zahra Ahmed, Angus Best, Joanne Dasgin, Mohammad Dinally, Elena Efstathiou, Theresa McCarthy, Madeeha Hoque, Shannon Page, Timothy Plant, Zehra Suleiman, Neil Townsend, Charlotte Trinham, Sinead Walder, Hollie Bancroft, Michelle Bates, Hayley Clifford, Christopher McGee, Samuel Chee, Lucy Common, Archana Herwadkar, Karen Knowles, Maria Poulaka, Georgina Davis, Daniel Mullan, Stuart Wareham, Fatima Dhalla, Rashmi Jain, Hadeil Morsi, Nicholas Peters, Mark Gompels, Malgorzata Slowinsksa, Dan Hartland, Emily Heritage, Joe Humphreys, Deborah Hughes, Ann Ivory, Sinead Kelly, Eileen O’Grady, Archana Shajidevadas
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundPatients with primary and secondary antibody deficiency are vulnerable to COVID-19 and demonstrate diminished responses following two-dose SARS-CoV-2 vaccine schedules. Third primary vaccinations have been deployed to enhance their humoral
Externí odkaz:
https://doaj.org/article/734129a987774428ad5c1764ee4dea11
Autor:
Ivan O. Rosas, Norbert Bräu, Michael Waters, Ronaldo C. Go, Atul Malhotra, Bradley D. Hunter, Sanjay Bhagani, Daniel Skiest, Sinisa Savic, Ivor S. Douglas, Julia Garcia-Diaz, Mariam S. Aziz, Nichola Cooper, Taryn Youngstein, Lorenzo Del Sorbo, David J. De La Zerda, Andrew Ustianowski, Antonio Cubillo Gracian, Kevin G. Blyth, Jordi Carratalà, Bruno François, Thomas Benfield, Derrick Haslem, Paolo Bonfanti, Cor H. van der Leest, Nidhi Rohatgi, Lothar Wiese, Charles Edouard Luyt, Rebecca N. Bauer, Fang Cai, Ivan T. Lee, Balpreet Matharu, Louis Metcalf, Steffen Wildum, Emily Graham, Larry Tsai, Min Bao
Publikováno v:
EClinicalMedicine, Vol 47, Iss , Pp 101409- (2022)
Summary: Background: In COVACTA, a randomised, placebo-controlled trial in patients hospitalised with coronavirus disease-19 (COVID-19), tocilizumab did not improve 28-day mortality, but shortened hospital and intensive care unit stay. Longer-term ef
Externí odkaz:
https://doaj.org/article/0cce1eb2d409455cafdb2877f5cbfad7
Autor:
Marta Wanat, Sibyl Anthierens, Marta Santillo, Catherine Porter, Joanne Fielding, Mina Davoudianfar, Emily Bongard, Ly-Mee Yu, Christopher Butler, Louise Savic, Sinisa Savic, Johanna Cook, Kelsey Armitage, Philip Howard, Sue Pavitt, Jonathan A. T. Sandoe, Sarah Tonkin-Crine
Publikováno v:
Medical Sciences Forum, Vol 15, Iss 1, p 8 (2023)
An estimated 2.7 million people in the UK are potentially prevented from accessing highly effective and inexpensive penicillins as a result of incorrect penicillin allergy records. Removing incorrect penicillin allergy records may lead to improved pa
Externí odkaz:
https://doaj.org/article/8e8e6421ad014e9b8448974f126ae35f