Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sining Leng"'
Autor:
Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V. Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T. Breault, David Penton
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low p
Externí odkaz:
https://doaj.org/article/17c862d14a5b4e46b23bf19918c8d968
Autor:
Aayushi Patel, Andrew Miles, Tara Strackhouse, Logan Cook, Sining Leng, Shrina Patel, Kelsey Klinger, Sairam Rudrabhatla, Shobha D. Potlakayala
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Agriculture has supported human life from the beginning of civilization, despite a plethora of biotic (pests, pathogens) and abiotic (drought, cold) stressors being exerted on the global food demand. In the past 50 years, the enhanced understanding o
Externí odkaz:
https://doaj.org/article/0d7903148e1743cf9e9d44bf9676e5f5
Autor:
Juliane Münch, Carolin Kloft, Madhi Farhan, Vladislav Fishman, Sining Leng, Hans Martin Bosse, Viviane Klingmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 701 (2023)
This single-centre, open-label, randomised, parallel-group study assessed the acceptability, swallowability, palatability, and safety of film-coated, 3 mm diameter mini-tablets in children aged ≥2–
Externí odkaz:
https://doaj.org/article/5b6560658f2a4014952f4718f015ec82
Autor:
Nick A. Guagliardo, Peter M. Klein, Christina A. Gancayco, Adam Lu, Sining Leng, Rany R. Makarem, Chelsea Cho, Craig G. Rusin, David T. Breault, Paula Q. Barrett, Mark P. Beenhakker
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Aldosterone-producing zona glomerulosa cells in the adrenal gland arrange into rosette structures known to be important for morphogenesis. Here the authors show that the cells in the rosettes produce coordinated calcium activity bursts in response to
Externí odkaz:
https://doaj.org/article/c1975079f3f541bbb5287c6fb622c60d
Autor:
Sining Leng, Emanuele Pignatti, Radhika S. Khetani, Manasvi S. Shah, Simiao Xu, Ji Miao, Makoto M. Taketo, Felix Beuschlein, Paula Q. Barrett, Diana L. Carlone, David T. Breault
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Multicellular rosettes are known to mediate complex cellular reorganization such as epithelial folding and branching during embryonal organogenesis. Here the authors show that rosette formation regulated by β-Catenin and FGFR2 mediate postnatal adre
Externí odkaz:
https://doaj.org/article/964dbe99eb3a48cf943bd37deee261d2
Autor:
Emanuele Pignatti, Sining Leng, Yixing Yuchi, Kleiton S. Borges, Nick A. Guagliardo, Manasvi S. Shah, Gerard Ruiz-Babot, Dulanjalee Kariyawasam, Makoto Mark Taketo, Ji Miao, Paula Q. Barrett, Diana L. Carlone, David T. Breault
Publikováno v:
Cell Reports, Vol 31, Iss 3, Pp - (2020)
Summary: Activating mutations in the canonical Wnt/β-catenin pathway are key drivers of hyperplasia, the gateway for tumor development. In a wide range of tissues, this occurs primarily through enhanced effects on cellular proliferation. Whether add
Externí odkaz:
https://doaj.org/article/475eba2b900146b99eaa1eb277eefd2f
Autor:
Mark P. Beenhakker, Nick A. Guagliardo, Rany R. Makarem, Craig G. Rusin, Christina A. Gancayco, Chelsea Cho, Paula Q. Barrett, Sining Leng, Peter M. Klein, Adam C Lu, David T. Breault
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications
Nature Communications
Aldosterone-producing zona glomerulosa (zG) cells of the adrenal gland arrange in distinct multi-cellular rosettes that provide a structural framework for adrenal cortex morphogenesis and plasticity. Whether this cyto-architecture also plays function
Autor:
Johannes Loffing, Mesut Berber, David Penton, Felix Beuschlein, David T. Breault, Sining Leng
Publikováno v:
The FASEB Journal. 35
Autor:
Emanuele Pignatti, William C. Engeland, David T. Breault, Mary E. Piper, Sining Leng, Paulo Kofuji, Shubhendu Mishra, Diana L. Carlone, Logan Massman, J. Marina Yoder
Publikováno v:
Endocrinology. 159:3950-3964
The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by an adrenal clock synchronized by SCN-dependent signals. Targeted deletion of the core clock gene Bma
Publikováno v:
Mol Cell Endocrinol
How morphology informs function is a fundamental biological question. Here, we review the morphological features of the adrenal zona glomerulosa (zG), highlighting recent cellular and molecular discoveries that govern its formation. The zG consists o