Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sini M. Kinnunen"'
Autor:
Mikael Jumppanen, Sini M. Kinnunen, Matej Zore, Mika J. Välimäki, Virpi Talman, Gustav Boije af Gennäs, Heikki J. Ruskoaho, Jari Yli-Kauhaluoma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Heart failure is a serious medical condition with a poor prognosis. Current treatments can only help manage the symptoms and slow the progression of heart failure. However, there is currently no cure to prevent and reverse cardiac remodeling
Externí odkaz:
https://doaj.org/article/2029b729860d4650ad7fb8a5f2680938
Autor:
Lotta Pohjolainen, Sini M. Kinnunen, Samuli Auno, Alexandros Kiriazis, Saana Pohjavaara, Julia Kari-Koskinen, Matej Zore, Mikael Jumppanen, Jari Yli-Kauhaluoma, Virpi Talman, Heikki Ruskoaho, Mika J. Välimäki
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Background The prevalence of heart failure is constantly increasing, and the prognosis of patients remains poor. New treatment strategies to preserve cardiac function and limit cardiac hypertrophy are therefore urgently needed. Human induced
Externí odkaz:
https://doaj.org/article/e9849cfeb7e34860b937a7a7a18376a5
Autor:
Mika J. Välimäki, Robert S. Leigh, Sini M. Kinnunen, Alexander R. March, Ana Hernández de Sande, Matias Kinnunen, Markku Varjosalo, Merja Heinäniemi, Bogac L. Kaynak, Heikki Ruskoaho
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-18 (2021)
Abstract Background Pharmacological modulation of cell fate decisions and developmental gene regulatory networks holds promise for the treatment of heart failure. Compounds that target tissue-specific transcription factors could overcome non-specific
Externí odkaz:
https://doaj.org/article/614c3e9ddc044f04a27581297b6207ab
Autor:
Laura Vainio, Saija Taponen, Sini M. Kinnunen, Eveliina Halmetoja, Zoltan Szabo, Tarja Alakoski, Johanna Ulvila, Juhani Junttila, Päivi Lakkisto, Johanna Magga, Risto Kerkelä
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13586 (2021)
Prior studies show that glycogen synthase kinase 3β (GSK3β) contributes to cardiac ischemic injury and cardiac hypertrophy. GSK3β is constitutionally active and phosphorylation of GSK3β at serine 9 (S9) inactivates the kinase and promotes cellula
Externí odkaz:
https://doaj.org/article/8de1a1bbbd7d42f4ab4e54d5aacbe51b