Výsledky vyhledávání - "Sini Flückiger-Isler"

Direct comparison of the Ames microplate format (MPF) test in liquid medium with the standard Ames pre-incubation assay on agar plates by use of equivocal to weakly positive test compounds

Autor: Markus Kamber, Sini Flückiger-Isler

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 747:36-45

The Ames microplate format (MPF™) test, which uses liquid media and in 384-well microplates with a readout based on a colour-change, has been used for over 10 years at several major pharmaceutical companies for screening the genotoxic potential of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c714fd34b0d89d676912df55c34f85
https://doi.org/10.1016/j.mrgentox.2012.03.014

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Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity

Autor: Markus Kamber, Rudolf Jaeckh, Errol Zeiger, Sini Flückiger-Isler, Giinter Engelhardt

Publikováno v: Mutagenesis. 24:359-366

The Ames II Salmonella mutagenicity assay procedure was used to test 71 chemicals, and the results were compared with those from the traditional Ames Salmonella test using the NTP database as the reference. All Ames II tests were performed using a fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75674c3660449992bfeabad275368e3f
https://doi.org/10.1093/mutage/gep017

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The Ames II and Ames MPF Penta I Assay: A Liquid Microplate Format Modification of the Classic Ames Test

Autor: Markus Kamber, Sini Flückiger-Isler

Publikováno v: Genotoxicity and DNA Repair ISBN: 9781493910670

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c583f05467ae58387a47d2ae32021cc
https://doi.org/10.1007/978-1-4939-1068-7_2

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Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments

Autor: Sini Flückiger-Isler, Tobias Schulze, Stefanie Lohrmann, Mahmoud Bataineh, Werner Brack, Jiri Neca, Urte Lübcke-von Varel, Ivonne Löffler, Miroslav Machala

Publikováno v: Environment International, Vol 44, Iss, Pp 31-39 (2012)

Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f17a4aa7c29fd6a2bb6dd34a0858fd
https://pubmed.ncbi.nlm.nih.gov/22336528

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Polar compounds dominate in vitro effects of sediment extracts

Autor: Jana M. Weiss, Katerina Pencikova, Miroslav Machala, Jan Vondráček, Jiri Neca, Urte Lübcke-von Varel, Marja H. Lamoree, Werner Brack, Sini Flückiger-Isler, Miroslav Ciganek, Georg Streck, Georg Reifferscheid, Ivonne Löffler, Lenka Pálková

Publikováno v: Environmental Science and Technology, 45(6), 2384-2390. American Chemical Society
Lubecke-von Varel, U, Machala, M, Ciganek, M, Neca, J, Pencikova, K, Palkova, L, Vondracek, J, Löffler, I, Streck, G, Reifferscheid, G, Flueckiger-Isler, S, Weiss, J M, Lamoree, M H & Brack, W 2011, ' Polar compounds dominate in vitro effects of sediment extracts ', Environmental Science and Technology, vol. 45, no. 6, pp. 2384-2390 . https://doi.org/10.1021/es103381y

Sediment extracts from three polluted sites of the river Elbe basin were fractionated using a novel on-line fractionation procedure. Resulting fractions were screened for mutagenic, aryl hydrocarbon (AhR)-mediated, transthyretin (TTR)-binding and est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4667a24c88938e68119136975e646b4c
http://publications.jrc.ec.europa.eu/repository/handle/JRC61139

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Comparison of the Salmonella/microsome microsuspension assay with the new microplate fluctuation protocol for testing the mutagenicity of environmental samples

Autor: Sini Flückiger-Isler, Gisela de Aragão Umbuzeiro, Simone Correia, Markus Kamber, Giselli Helena Lima Cardenette, Célia Maria Rech, Ana Marcela Di Dea Bergamasco

Publikováno v: Environmental and Molecular Mutagenesis.

The objective of this study was to compare the responses of the Salmonella/microsome microsuspension assay with the new microplate fluctuation protocol (MPF) for the evaluation of the mutagenic activity of environmental samples. Organic extracts of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2c35b0ee142d1b21ad9bcb8544180c
https://doi.org/10.1002/em.20504

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