Convection enhanced delivery of panobinostat (LBH589)-loaded pluronic nano-micelles prolongs survival in the F98 rat glioma model

Autor: Singleton WG, Collins AM, Bienemann AS, Killick-Cole CL, Haynes HR, Asby DJ, Butts CP, Wyatt MJ, Barua NU, Gill SS

Publikováno v: International Journal of Nanomedicine, Vol Volume 12, Pp 1385-1399 (2017)

WG Singleton,1,2 AM Collins,3 AS Bienemann,1 CL Killick-Cole,1 HR Haynes,4 DJ Asby,1 CP Butts,5 MJ Wyatt,1 NU Barua,1,2 SS Gill1,2 1Functional Neurosurgery Research Group, School of Clinical Sciences, University of Bristol, 2Department of Neurosurger

Externí odkaz: https://doaj.org/article/aab501023622452a81f2d895f5be6579

shRNA-mediated PPARα knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth.

Autor: Haynes HR; Brain Tumour Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Department of Cellular Pathology, North Bristol NHS Trust, Bristol, UK., Scott HL; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Killick-Cole CL; Functional Neurosurgery Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Shaw G; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Brend T; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Hares KM; Multiple Sclerosis and Stem Cell Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Redondo J; Multiple Sclerosis and Stem Cell Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kemp KC; Multiple Sclerosis and Stem Cell Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Ballesteros LS; Flow Cytometry Facility, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Herman A; Flow Cytometry Facility, School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK., Cordero-Llana O; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Singleton WG; Functional Neurosurgery Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Department of Neurosurgery, North Bristol NHS Trust, Bristol, UK., Mills F; Department of Clinical Biochemistry, North Bristol NHS Trust, Bristol, UK., Batstone T; Bioinformatics Facility, School of Biological Sciences, University of Bristol, Bristol, UK., Bulstrode H; Department of Clinical Neuroscience and Stem Cell Institute, University of Cambridge, Cambridge, UK., Kauppinen RA; Clinical Research and Imaging Centre, University of Bristol, Bristol, UK., Wurdak H; Stem Cells and Brain Tumour Group, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Uney JB; Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Short SC; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK., Wilkins A; Multiple Sclerosis and Stem Cell Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Kurian KM; Brain Tumour Research Group, Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Publikováno v: The Journal of pathology [J Pathol] 2019 Apr; Vol. 247 (4), pp. 422-434. Date of Electronic Publication: 2018 Dec 27.

Therapeutic Targeting of Histone Modifications in Adult and Pediatric High-Grade Glioma.

Autor: Williams MJ; Brain Tumour Research Group, Institute of Clinical Neurosciences, University of Bristol , Bristol , UK., Singleton WG; Functional Neurosurgery Research Group, Institute of Clinical Neurosciences, University of Bristol , Bristol , UK., Lowis SP; Department of Paediatric and Adolescent Oncology, Bristol Royal Hospital for Children , Bristol , UK., Malik K; Cancer Epigenetics Laboratory, Cellular and Molecular Medicine, University of Bristol , Bristol , UK., Kurian KM; Brain Tumour Research Group, Institute of Clinical Neurosciences, University of Bristol , Bristol , UK.

Publikováno v: Frontiers in oncology [Front Oncol] 2017 Mar 28; Vol. 7, pp. 45. Date of Electronic Publication: 2017 Mar 28 (Print Publication: 2017).

Chronic headaches due to periventricular nodular heterotopia causing obstructive hydrocephalus.

Autor: Singleton WG; Department of Paediatric Neurosurgery, Frenchay Hospital, Bristol, UK., Bacon A, Edwards RJ

Publikováno v: Pediatric neurosurgery [Pediatr Neurosurg] 2012; Vol. 48 (4), pp. 258-60. Date of Electronic Publication: 2013 Apr 06.

Amyloidosis presenting as bilateral transudative pleural effusions with normal cardiac investigations: a case report.

Autor: Briggs JH; Department of Respiratory Medicine, Heatherwood and Wexham Park Hospitals NHS Foundation Trust, King Edward VII Hospital,Windsor, Berkshire, SL4 3DP, UK. jhbriggs@mac.com, Singleton WG, Burke MM, Hart LA, Parker RJ

Publikováno v: Cases journal [Cases J] 2009 Jul 21; Vol. 2, pp. 6963. Date of Electronic Publication: 2009 Jul 21.