Zobrazeno 1 - 10
of 449
pro vyhledávání: '"Single-cell OMICs"'
Autor:
Shuang Zhou, Nanfei Lin, Liying Yu, Xiaoshan Su, Zhenlong Liu, Xiaowan Yu, Hongzhi Gao, Shu Lin, Yiming Zeng
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 431-445 (2024)
Digestive system cancers are prevalent diseases with a high mortality rate, posing a significant threat to public health and economic burden. The diagnosis and treatment of digestive system cancer confront conventional cancer problems, such as tumor
Externí odkaz:
https://doaj.org/article/d011d875492847e59ece547666389729
Autor:
Xinyu Guo, Wenyan Jin, Yuchen Wen, Zhiqin Wang, Xiaotong Ren, Zhaoyun Liu, Rong Fu, Zhigang Cai, Lijuan Li
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Myelodysplastic syndrome (MDS) is a complicated hematopoietic malignancy characterized by bone marrow (BM) dysplasia with symptoms like anemia, neutropenia, or thrombocytopenia. MDS exhibits considerable heterogeneity in prognosis
Externí odkaz:
https://doaj.org/article/c5c0e8f4b0e844d2a0ad9963d12ce26e
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/f8548cfd4bce48b89f21de407e10b78a
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract The Drosophila eye has been an important model to understand principles of differentiation, proliferation, apoptosis and tissue morphogenesis. However, a single cell RNA sequence resource that captures gene expression dynamics from the initi
Externí odkaz:
https://doaj.org/article/5e03546cc0204130927c7bb86ef5bb06
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-9 (2024)
Abstract This review examines how single-cell omics technologies, particularly single-cell RNA sequencing (scRNAseq), enhance our understanding of pulmonary arterial hypertension (PAH). PAH is a multifaceted disorder marked by pulmonary vascular remo
Externí odkaz:
https://doaj.org/article/d35f57d68afa4dd9aa1b3db58e7eb01e
Autor:
Lu Pan, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker M. Lauschke, Bradley A. Maron, Paola Paci, Ingemar Ernberg, Nguan Soon Tan, Zehuan Liao, Weiyao Yin, Sundararaman Rengarajan, Xuexin Li, The SCA Consortium
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-21 (2024)
Abstract Single-cell sequencing datasets are key in biology and medicine for unraveling insights into heterogeneous cell populations with unprecedented resolution. Here, we construct a single-cell multi-omics map of human tissues through in-depth cha
Externí odkaz:
https://doaj.org/article/bfac2c6a06f6422a8ceb3444a8f601fb
Publikováno v:
Biomarker Research, Vol 12, Iss 1, Pp 1-28 (2024)
Abstract Tumor-associated macrophages (TAMs) are a heterogeneous population that play diverse functions in tumors. Their identity is determined not only by intrinsic factors, such as origins and transcription factors, but also by external signals fro
Externí odkaz:
https://doaj.org/article/185594542fa441fdb008711f7a0a1b6f
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/33479fce00784d0aaa14e0a46239f0ff
Publikováno v:
BMC Genomics, Vol 24, Iss 1, Pp 1-17 (2023)
Abstract In recent single-cell -omics studies, both the differential activity of transcription factors regulating cell fate determination and differential genome activation have been tested for utility as descriptors of cell types. Naturally, genome
Externí odkaz:
https://doaj.org/article/c97863e09d7c49dab090a6788d3c8122
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 21, Iss 5, Pp 950-961 (2023)
During mammalian preimplantation development, a totipotent zygote undergoes several cell cleavages and two rounds of cell fate determination, ultimately forming a mature blastocyst. Along with compaction, the establishment of apicobasal cell polarity
Externí odkaz:
https://doaj.org/article/64db95cec60b401b929b34f8275d0f3f