Zobrazeno 1 - 10
of 413
pro vyhledávání: '"Single chain fragment variable"'
Autor:
Rukhshan Zahid, Juncheng Wang, Zecheng Cai, Ayesha Ishtiaq, Meng Liu, Dan Ma, Yan Liang, Yuekang Xu
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Cardiovascular diseases (CVDs) remain a significant global health challenge, leading to substantial morbidity and mortality. Despite recent advancements in CVD management, pharmaceutical treatments often suffer from poor pharmacokinetics and high tox
Externí odkaz:
https://doaj.org/article/0f3adf6caf7340fa983bd5f07dd00738
Autor:
Hamideh Raeisi, Mohammad Reza Safarnejad, Seyed Mehdi Alavi, Maxuel de Oliveira Andrade, Naser Farrokhi, Seyed Ali Elahinia
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Citrus canker is a bacterial disease caused by Xanthomonas citri subsp. citri (Xcc) that affects the citrus industry worldwide. Hrp pili subunits (HrpE), an essential component of Type III secretion system (T3SS) bacteria, play a crucial rol
Externí odkaz:
https://doaj.org/article/6ad4f43af4784cdc940e5f58b32e3597
Publikováno v:
مجله علمی دانشگاه علوم پزشکی کردستان, Vol 28, Iss 4, Pp 12-23 (2023)
Background and Aim: Conventional treatments have shown little success in cancer treatment. Using antibody fragments conjugated with specific proteins and targeting specific receptors is a new strategy for producing anticancer drugs. Despite the advan
Externí odkaz:
https://doaj.org/article/9489d72e67d74ab2ae9f5fc3dba58d2c
Publikováno v:
PeerJ, Vol 12, p e17143 (2024)
Phage display technology has become an important research tool in biological research, fundamentally changing the traditional monoclonal antibody preparation process, and has been widely used in the establishment of antigen-antibody libraries, drug d
Externí odkaz:
https://doaj.org/article/8018e25c42b84663a3db61c173f900ab
Autor:
Lidia Riaño-Umbarila, Timoteo Olamendi-Portugal, José Alberto Romero-Moreno, Gustavo Delgado-Prudencio, Fernando Z. Zamudio, Baltazar Becerril, Lourival D. Possani
Publikováno v:
Toxins, Vol 16, Iss 7, p 301 (2024)
Alternative recombinant sources of antivenoms have been successfully generated. The application of such strategies requires the characterization of the venoms for the development of specific neutralizing molecules against the toxic components. Five t
Externí odkaz:
https://doaj.org/article/2757b26640214d0bb2e84de5a5f7c203
Publikováno v:
Foods, Vol 13, Iss 13, p 2009 (2024)
Deoxynivalenol (DON) is a common mycotoxin that contaminates cereals. Therefore, the development of sensitive and efficient detection methods for DON is essential to guarantee food safety and human health. In this study, an enzyme cascade amplificati
Externí odkaz:
https://doaj.org/article/b7f9f9df1fb8499baa270ca9b5ae72b4
Autor:
Hocheol Lim, Kyoung Tai No
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Background Monoclonal antibodies (mAbs) have been used as therapeutic agents, which must overcome many developability issues after the discovery from in vitro display libraries. Especially, polyreactive mAbs can strongly bind to a specific t
Externí odkaz:
https://doaj.org/article/3d2513a4031c4213ae01ca396b072fff
Autor:
Hamideh Raeisi, Masoumeh Azimirad, Hamid Asadzadeh Aghdaei, Amir-Hassan Zarnani, Jalal Abdolalizadeh, Abbas Yadegar, Mohammad Reza Zali
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 5 (2023)
ABSTRACT TcdA and TcdB are known as the major virulence attributes of Clostridioides difficile. Hence, neutralizing the TcdA and TcdB activities can be considered as an efficient therapeutic approach against C. difficile infection (CDI). In this work
Externí odkaz:
https://doaj.org/article/3f88b7890aa4434fb990d70e393d138e
Akademický článek
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Autor:
Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionChimeric antigen receptor T (CAR-T) cell therapy presents a promising treatment option for various cancers, including solid tumors. Carcinoembryonic antigen (CEA) is an attractive target due to its high expression in many tumors, particul
Externí odkaz:
https://doaj.org/article/1415e85e1eaf46499d38e7b6799f482d