Zobrazeno 1 - 10
of 490
pro vyhledávání: '"Single cell RNAseq"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Dysfunction of motile cilia can impair mucociliary clearance in the airway and result in primary ciliary dyskinesia (PCD). We previously showed that mutations in central pair apparatus (CPA) genes perturb ciliary motility and result in PCD i
Externí odkaz:
https://doaj.org/article/45e7917a3d85434eaec4c01203fb4161
Autor:
Beatriz Miguelena Chamorro, Sodiq Ayobami Hameed, Jean-Baptiste Claude, Lauriane Piney, Ludivine Chapat, Gokul Swaminathan, Hervé Poulet, Karelle De Luca, Egbert Mundt, Stéphane Paul
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-6 (2024)
Abstract In the human and veterinary fields, oral vaccines generate considerable interest. In dogs, these vaccines are newly developed, and understanding their mechanisms is crucial. Mesenteric lymph nodes (MLNs) and Peyer's patches (PPs) are importa
Externí odkaz:
https://doaj.org/article/7ecace756129414b95374e5e8b17eece
Assessing transcriptomic heterogeneity of single-cell RNASeq data by bulk-level gene expression data
Publikováno v:
BMC Bioinformatics, Vol 25, Iss 1, Pp 1-35 (2024)
Abstract Background Single-cell RNA sequencing (sc-RNASeq) data illuminate transcriptomic heterogeneity but also possess a high level of noise, abundant missing entries and sometimes inadequate or no cell type annotations at all. Bulk-level gene expr
Externí odkaz:
https://doaj.org/article/0166b14c9e644ff1b5c5c99a4ab226c6
Autor:
Shanshan Song, Helena Oft, Shamseldin Metwally, Satya Paruchuri, John Bielanin, Victoria Fiesler, Chaim Sneiderman, Gary Kohanbash, Dandan Sun
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-19 (2024)
Abstract Microglial Na/H exchanger-1 (NHE1) protein, encoded by Slc9a1, plays a role in white matter demyelination of ischemic stroke brains. To explore underlying mechanisms, we conducted single cell RNA-seq transcriptome analysis in conditional Slc
Externí odkaz:
https://doaj.org/article/05706d6ac14f40cf989e0aa769aef028
Autor:
Alberto Ayllon-Hermida, Marc Nicolau-Fernandez, Ane M. Larrinaga, Iris Aparici-Herraiz, Elisabet Tintó-Font, Oriol Llorà-Batlle, Agnes Orban, María Fernanda Yasnot, Mariona Graupera, Manel Esteller, Jean Popovici, Alfred Cortés, Hernando A. del Portillo, Carmen Fernandez-Becerra
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Recent studies indicate that human spleen contains over 95% of the total parasite biomass during chronic asymptomatic infections caused by Plasmodium vivax. Previous studies have demonstrated that extracellular vesicles (EVs) secreted from infected r
Externí odkaz:
https://doaj.org/article/4c0c66b50a03457bb1b958779ad6f4d4
Autor:
Leshan Wang, Peidong Gao, Chaoyang Li, Qianglin Liu, Zeyang Yao, Yuxia Li, Xujia Zhang, Jiangwen Sun, Constantine Simintiras, Matthew Welborn, Kenneth McMillin, Stephanie Oprescu, Shihuan Kuang, Xing Fu
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 2152-2167 (2023)
Abstract Background Intramuscular fat (IMF) and intramuscular connective tissue (IMC) are often seen in human myopathies and are central to beef quality. The mechanisms regulating their accumulation remain poorly understood. Here, we explored the pos
Externí odkaz:
https://doaj.org/article/e77cbf1d0fc54af0a6bb0da511022bf8
Autor:
Amadeo Muñoz García, Juri Juksar, Nathalie Groen, Arnaud Zaldumbide, Eelco de Koning, Françoise Carlotti
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionInflammation of the pancreas contributes to the development of diabetes mellitus. Although it is well-accepted that local inflammation leads to a progressive loss of functional beta cell mass that eventually causes the onset of the diseas
Externí odkaz:
https://doaj.org/article/d57e3b657e1449fa8533efe9f3165e01
Autor:
Md Jashim Uddin, Brandon Thompson, Jhansi L. Leslie, Casey Fishman, Katia Sol-church, Pankaj Kumar, William A. Petri
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT Innate lymphoid cells (ILCs) play a critical role in maintaining intestinal health in homeostatic and diseased conditions. During Clostridium difficile infection (CDI), IL-33 activates ILC2 to protect from colonic damage and mortality. The f
Externí odkaz:
https://doaj.org/article/a9114d612dec4b05b683cdb7d721fb7b
Autor:
Aixin Zhang, Lei Jin, Shenqin Yao, Makoto Matsuyama, Cindy TJ van Velthoven, Heather Anne Sullivan, Na Sun, Manolis Kellis, Bosiljka Tasic, Ian Wickersham, Xiaoyin Chen
Publikováno v:
eLife, Vol 12 (2024)
Mapping the connectivity of diverse neuronal types provides the foundation for understanding the structure and function of neural circuits. High-throughput and low-cost neuroanatomical techniques based on RNA barcode sequencing have the potential to
Externí odkaz:
https://doaj.org/article/112417cc5f8d47a4bcb098605ba0a640
Publikováno v:
Journal of Inflammation Research, Vol Volume 16, Pp 2129-2147 (2023)
Chao Cao,1– 4 Obulkasim Memet,1– 3 Fuli Liu,1,2 Hanbing Hu,1– 3 Lin Zhang,1,2 Heng Jin,4 Yiqun Cao,4 Jian Zhou,3,5,6 Jie Shen1– 3 1Center of Emergency and Critical Medicine, Jinshan Hospital of Fudan University, Shanghai, People’s Republic
Externí odkaz:
https://doaj.org/article/615049c6f3854d49a38ce73bee5ed230