Zobrazeno 1 - 10
of 2 573
pro vyhledávání: '"Single Particle Analysis"'
Publikováno v:
IUCrJ, Vol 11, Iss 5, Pp 723-729 (2024)
Single-particle cryo-electron microscopy (cryo-EM) has become an essential structural determination technique with recent hardware developments making it possible to reach atomic resolution, at which individual atoms, including hydrogen atoms, can be
Externí odkaz:
https://doaj.org/article/274a233e1353469aa8ae96e18a562693
Autor:
Yi-Ning Hou, Li-Juan Zhang, Lei Du, Dan-Dan Fu, Jing Li, Liu Liu, Peng-Fei Xu, Ya-Wen Zheng, Dai-Wen Pang, Hong-Wu Tang
Publikováno v:
Virulence, Vol 15, Iss 1 (2024)
Viral diseases are among the main threats to public health. Understanding the factors affecting viral invasion is important for antiviral research. Until now, it was known that most viruses have very low plaque-forming unit (PFU)-to-particle ratios.
Externí odkaz:
https://doaj.org/article/e39b4e3d47f440e9a1d6ce2935590979
Publikováno v:
Fundamental Research, Vol 3, Iss 4, Pp 488-504 (2023)
Lipid-based nanomedicines (LBNMs), including liposomes, lipid nanoparticles (LNPs) and extracellular vesicles (EVs), are recognized as one of the most clinically acceptable nano-formulations. However, the bench-to-bedside translation efficiency is fa
Externí odkaz:
https://doaj.org/article/c2e9cf6b59344fa182a908557a8af8a8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Structure-based drug design (SBDD) has gained popularity owing to its ability to develop more potent drugs compared to conventional drug-discovery methods. The success of SBDD relies heavily on obtaining the three-dimensional structures of drug targe
Externí odkaz:
https://doaj.org/article/53e527e4c07343eca4ca344c878f7bd0
Autor:
Bernhard Schuster
Publikováno v:
eLife, Vol 13 (2024)
The surface layer of Sulfolobus acidocaldarius consists of a flexible but stable outer protein layer that interacts with an inner, membrane-bound protein.
Externí odkaz:
https://doaj.org/article/59b53e3af8444e468d2a52a9bcfb4bd5
Publikováno v:
Current Research in Structural Biology, Vol 7, Iss , Pp 100143- (2024)
The 21st amino acid, selenocysteine (Sec), is synthesized on its dedicated transfer RNA (tRNASec). In bacteria, Sec is synthesized from Ser-tRNA[Ser]Sec by Selenocysteine Synthase (SelA), which is a pivotal enzyme in the biosynthesis of Sec. The stru
Externí odkaz:
https://doaj.org/article/8b684bcf006f41a59ed54c861d9482ae
Publikováno v:
Biological Imaging, Vol 4 (2024)
Cryo-electron microscopy (cryo-EM) is an imaging technique that allows the visualization of proteins and macromolecular complexes at near-atomic resolution. The low electron doses used to prevent radiation damage to the biological samples result in i
Externí odkaz:
https://doaj.org/article/2f70dd78e4864697b9b42a4bc2d7e0af
Autor:
Lavinia Gambelli, Mathew McLaren, Rebecca Conners, Kelly Sanders, Matthew C Gaines, Lewis Clark, Vicki AM Gold, Daniel Kattnig, Mateusz Sikora, Cyril Hanus, Michail N Isupov, Bertram Daum
Publikováno v:
eLife, Vol 13 (2024)
Surface layers (S-layers) are resilient two-dimensional protein lattices that encapsulate many bacteria and most archaea. In archaea, S-layers usually form the only structural component of the cell wall and thus act as the final frontier between the
Externí odkaz:
https://doaj.org/article/42b28b40f3aa4a40a7d545c8974c8522
Autor:
Yongmin Kwon, Jaesung Park
Publikováno v:
Micro and Nano Systems Letters, Vol 10, Iss 1, Pp 1-13 (2022)
Abstract Extracellular vesicles (EVs) are nano-sized vesicles derived from cells that transport biomaterials between cells through biofluids. Due to their biological role and components, they are considered as potential drug carriers and for diagnost
Externí odkaz:
https://doaj.org/article/c51fad08ee524691878195815586149a
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 8, Pp n/a-n/a (2023)
Abstract Although lipophilic membrane dyes (LMDs) or probes (LMPs) are widely used to label extracellular vesicles (EVs) for detection and purification, their labelling performance has not been systematically characterized. Through concurrent side sc
Externí odkaz:
https://doaj.org/article/d1cdbc85dfd04aae8c9eeb3e7a9fbe47