Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Single Domain Antibodies, Libraries and Innovations"'
Autor:
Lilia A. Rabia, Kathryn E. Tiller, Evan K. Day, Mark C. Julian, Christine C. Lee, Peter M. Tessier, Arthur J. Schick
Publikováno v:
Protein Engineering Design and Selection. 28:339-350
An attractive approach for designing lead antibody candidates is to mimic natural protein interactions by grafting peptide recognition motifs into the complementarity-determining regions (CDRs). We are using this approach to generate single-domain (V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3353117125bd1696a4197638dfca7f98
https://doi.org/10.1093/protein/gzv050
https://doi.org/10.1093/protein/gzv050
Autor:
Jennifer L. Johnson, Raquel L. Lieberman, Kevin C. Entzminger, Jennifer A. Maynard, Jeongmin Hyun
Publikováno v:
Protein Engineering Design and Selection. 28:365-377
Antibody aggregation is frequently mediated by the complementarity determining regions within the variable domains and can significantly decrease purification yields, shorten shelf-life and increase the risk of anti-drug immune responses. Aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6a0fad3dbaf1880a814bf4300fa593
https://doi.org/10.1093/protein/gzv037
https://doi.org/10.1093/protein/gzv037