Výsledky vyhledávání - "Singireddi Srinivasarao"

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Seeking potent anti-tubercular agents: design and synthesis of substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives as anti-tubercular agents

Autor: Davie Cappoen, Adinarayana Nandikolla, Linda De Voogt, A.V. Suresh, Kondapalli Venkata Gowri Chandra Sekhar, Kevin Van Calster, Sankaranarayanan Murugesan, Balaram Ghosh, Himanshu Aggarwal, Singireddi Srinivasarao

Publikováno v: RSC Advances. 10:12272-12288

Pyrazinamide is an important first-line drug used in shortening TB therapy. In our current work, a series of novel substituted-N-(6-(4-(pyrazine-2-carbonyl)piperazine/homopiperazine-1-yl)pyridin-3-yl)benzamide derivatives were designed, synthesized,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3769cc4648c0eb5f322d1d2fd9e437f
https://doi.org/10.1039/d0ra01348j

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Design, synthesis and biological evaluation of 1,2,3-triazole based 2-aminobenzimidazoles as novel inhibitors of LasR dependent quorum sensing in Pseudomonas aeruginosa

Autor: Naresh Kumar, Singireddi Srinivasarao, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar, Tsz Tin Yu, Adinarayana Nandikolla, Balaram Ghosh, Shashidhar Nizalapur, Sravani Pulya

Publikováno v: RSC Advances. 9:29273-29292

Bacteria regulate their phenotype, growth and population via a signalling pathway known as quorum sensing. In this process, bacteria produce signalling molecules (autoinducers) to recognize their population density. Inhibiting this quorum sensing sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db5161db7d144eb076be51dd4c8b1f8a
https://doi.org/10.1039/c9ra05059k

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Design, synthesis and biological evaluation of novel 1,2,3-triazole analogues of Imidazo-[1,2-a]-pyridine-3-carboxamide against Mycobacterium tuberculosis

Autor: Scott G. Franzblau, Banoth Karan Kumar, Adinarayana Nandikolla, Kondapalli Venkata Gowri Chandra Sekhar, Gauri Shetye, Sankaranarayanan Murugesan, Singireddi Srinivasarao, Rui Ma, Yogesh Mahadu Khetmalis

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 74

Twenty-eight novel 1,2,3-triazole analogues of imidazo-[1,2-a]-pyridine-3-carboxamide were designed and synthesized based on hybridization approach. The structure of the final compounds are characterized using 1HNMR, 13CNMR, LCMS and elemental analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c494900b877d016e182b17733c784912
https://pubmed.ncbi.nlm.nih.gov/33684466

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Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues

Autor: Louise L. Major, Singireddi Srinivasarao, Kondapalli Venkata Gowri Chandra Sekhar, Adinarayana Nandikolla, Sankaranarayanan Murugesan, Banoth Karan Kumar, Terry K. Smith, Himanshu Aggarwal

KVGCS and SM thank DBT, New Delhi [BT/IN/Spain/39/SMl2017-18] for providing financial support. The financial assistance provided by DIST FIST grant (SR/FST/CSI-240/2012), New Delhi is gratefully acknowledged. SS thanks CSIR for providing SRF fellowsh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81be590f4a33b9f7b1dada3060ac7b4f
https://hdl.handle.net/10023/20969

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Inhibitors of pantothenate synthetase of

Autor: Amaroju, Suresh, Singireddi, Srinivasarao, Yogesh Mahadu, Khetmalis, Shashidhar, Nizalapur, Murugesan, Sankaranarayanan, Kondapalli Venkata, Gowri Chandra Sekhar

Publikováno v: RSC advances. 10(61)

Tuberculosis (TB), one of the most prevalent infections, is on the rise today. Although there are drugs available in the market to combat this lethal disorder, there are several shortcomings with the current drug regimen, such as prolonged treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::477b9646af0da2a001b245a4a2535dca
https://pubmed.ncbi.nlm.nih.gov/35521286

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Discovery of 1,2,3-triazole based quinoxaline-1,4-di-N-oxide derivatives as potential anti-tubercular agents

Autor: Augustynowicz-Kopeć Ewa, Agnieszka Głogowska, Sravani Pulya, Himanshu Aggarwal, Kondapalli Venkata Gowri Chandra Sekhar, Adinarayana Nandikolla, Sankaranarayanan Murugesan, Balaram Ghosh, Singireddi Srinivasarao, Banoth Karan Kumar, A.V. Suresh

Publikováno v: Bioorganic chemistry. 100

A series of thirty one novel 2-(((1-(substituted phenyl)-1H-1,2,3-triazol-4-yl)methoxy)carbonyl)-3-methylquinoxaline-1,4-dioxide (7a-l), 3-(((1-(substituted phenyl)-1H-1,2,3-triazol-4-yl)methoxy)carbonyl)-6-chloro-2-methylquinoxaline-1,4-dioxide (8a-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9023ec33300547827d8a6e0857b6cd7
https://pubmed.ncbi.nlm.nih.gov/32464405

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Novel phenanthridine amide analogs as potential anti-leishmanial agents: In vitro and in silico insights

Autor: Banoth Karan Kumar, Singireddi Srinivasarao, Rafael Balaña-Fouce, Sankaranarayanan Murugesan, Yolanda Pérez-Pertejo, Adinarayana Nandikolla, Estela Melcon-Fernandez, Himanshu Aggarwal, Kondapalli Venkata Gowri Chandra Sekhar

Publikováno v: Bioorganic Chemistry. 117:105414

In the current work, sixteen novel amide derivatives of phenanthridine were designed and synthesized using 9-fluorenone, 4-Methoxy benzyl amine, and alkyl/aryl acids. The characterization of the title compounds was performed using LCMS, elemental ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb457d35ab2b230346d54e35846d49e6
https://doi.org/10.1016/j.bioorg.2021.105414

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