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Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.

Autor: Harris PA, Berger SB, Jeong JU, Nagilla R, Bandyopadhyay D, Campobasso N, Capriotti CA, Cox JA, Dare L, Dong X, Eidam PM, Finger JN, Hoffman SJ, Kang J, Kasparcova V, King BW, Lehr R, Lan Y, Leister LK, Lich JD, MacDonald TT; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Miller NA, Ouellette MT, Pao CS, Rahman A, Reilly MA, Rendina AR, Rivera EJ, Schaeffer MC, Sehon CA, Singhaus RR, Sun HH, Swift BA, Totoritis RD, Vossenkämper A; Centre for Immunobiology, Blizard Institute, Barts, and The London School of Medicine and Dentistry, Queen Mary University of London , E1 2AD London, U.K., Ward P, Wisnoski DD, Zhang D, Marquis RW, Gough PJ, Bertin J

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2017 Feb 23; Vol. 60 (4), pp. 1247-1261. Date of Electronic Publication: 2017 Feb 10.

4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.

Autor: Bernotas RC; Chemical Sciences, Wyeth Pharmaceuticals, 500 Arcola Road, Collegeville, PA 19426, USA. bernotr@wyeth.com, Singhaus RR, Kaufman DH, Travins JM, Ullrich JW, Unwalla R, Quinet E, Evans M, Nambi P, Olland A, Kauppi B, Wilhelmsson A, Goos-Nilsson A, Wrobel J

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 01; Vol. 20 (1), pp. 209-12. Date of Electronic Publication: 2009 Oct 31.

Biarylether amide quinolines as liver X receptor agonists.

Autor: Bernotas RC; Chemical and Screening Sciences, Wyeth Pharmaceuticals, 500 Arcola Road, Collegeville, PA 19426, USA. bernotr@wyeth.com, Singhaus RR, Kaufman DH, Ullrich J, Fletcher H 3rd, Quinet E, Nambi P, Unwalla R, Wilhelmsson A, Goos-Nilsson A, Farnegardh M, Wrobel J

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2009 Feb 15; Vol. 17 (4), pp. 1663-70. Date of Electronic Publication: 2008 Dec 27.

Synthesis of 1-Amino-3-[2-(1,7-dicarba-closo-dodecaboran(12)-1-yl)ethyl]cyclobutanecarboxylic Acid: A Potential BNCT Agent.

Autor: Srivastava RR; Departments of Chemistry and Radiology, University of Tennessee, Knoxville, Tennessee 37996-1600., Singhaus RR, Kabalka GW

Publikováno v: The Journal of organic chemistry [J Org Chem] 1997 Jun 27; Vol. 62 (13), pp. 4476-4478.