Atomically accurate de novo design of single-domain antibodies.

Autor: Bennett NR; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA., Watson JL; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Ragotte RJ; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Borst AJ; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., See DL; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Weidle C; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Biswas R; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA., Shrock EL; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Leung PJY; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Graduate Program in Molecular Engineering, University of Washington, Seattle, WA 98105, USA., Huang B; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Department of Bioengineering, University of Washington, Seattle, WA, USA., Goreshnik I; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA., Ault R; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.; Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA., Carr KD; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Singer B; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Criswell C; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Vafeados D; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Sanchez MG; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Kim HM; Center for Biomolecular and Cellular Structure, Institute for Basic Science (IBS), Daejeon, 34126, Republic of Korea.; Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea., Torres SV; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Graduate Program in Biological Physics, Structure and Design, University of Washington, Seattle, WA, USA., Chan S; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA., Baker D; Department of Biochemistry, University of Washington, Seattle, WA 98105, USA.; Institute for Protein Design, University of Washington, Seattle, WA 98105, USA.; Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 18. Date of Electronic Publication: 2024 Mar 18.