Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Sinensky, Michael"'
Autor:
Dechat, Thomas, Shimi, Takeshi, Adam, Stephen A., Rusinol, Antonio E., Andres, Douglas A., Spielmann, H. Peter, Sinensky, Michael S., Goldman, Robert D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2007 Mar . 104(12), 4955-4960.
Externí odkaz:
https://www.jstor.org/stable/25427126
Autor:
Rusiñol, Antonio E., Yang, Lin, Thewke, Douglas, Panini, Sankhavaram R., Kramer, Marianne F., Sinensky, Michael S.
Publikováno v:
ETSU Faculty Works.
Oxidized low density lipoprotein (oxLDL) induces apoptosis in macrophages, smooth muscle cells, and endothelial cells. To elucidate the molecular mechanism of oxLDL-induced cytotoxicity and determine its tissue specificity, we have used Chinese hamst
Autor:
Rusiñol, Antonio E., Thewke, Douglas, Liu, June, Freeman, Natalie, Panini, Sankhavaram R., Sinensky, Michael S.
Publikováno v:
ETSU Faculty Works.
Cells of the vasculature, including macrophages, smooth muscle cells, and endothelial cells, exhibit apoptosis in culture upon treatment with oxidized low density lipoprotein, as do vascular cells of atherosclerotic plaque. Several lines of evidence
Autor:
Freeman, Natalie E., Rusinol, Antonio E., Linton, MacRae, Hachey, David L., Fazio, Sergio, Sinensky, Michael S., Thewke, Douglas
Publikováno v:
ETSU Faculty Works.
7-Ketocholesterol (7KC) is a cytotoxic component of oxidized low density lipoproteins (OxLDLs) and induces apoptosis in macrophages by a mechanism involving the activation of cytosolic phospholipase A2 (cPLA 2). In the current study, we examined the
Autor:
Kilic, Fusun, Dalton, Marguerite B., Burrell, Sarah K., Mayer, John P., Patterson, Scott D., Sinensky, Michael
Publikováno v:
ETSU Faculty Works.
The 72-kDa nuclear lamina protein lamin A is synthesized as a 74-kDa farnesylated precursor. Conversion of this precursor to mature lamin A appears to be mediated by a specific endoprotease. Prior studies of overexpressed wild-type and mutant lamin A
Publikováno v:
ETSU Faculty Works.
Activation of genes containing SRE-1 (sterol regulatory element 1) sequences is known to be under the regulation of sterols through modulation of the proteolytic maturation of SREBPs (SRE-1-binding proteins). Previous work has demonstrated SREBP-medi
Publikováno v:
ETSU Faculty Works.
Oncogenic p21(ras) proteins can only exert their stimulation of cellular proliferation when plasma membrane-associated. This membrane association has an absolute requirement for post-translational modification with isoprenoids. The mechanism by which
Autor:
Panini, Sankhavaram R., Yang, Lin, Rusinol, Antonio E., Sinensky, Michael S., Bonventre, Joseph V., Leslie, Christina C.
Publikováno v:
ETSU Faculty Works.
Owing at least in part to oxysterol components that can induce apoptosis, oxidized LDL (oxLDL) is cytotoxic to mammalian cells with receptors that can internalize it. Vascular cells possess such receptors, and it appears that the apoptotic response o
Externí odkaz:
https://dc.etsu.edu/etsu-works/19101
Autor:
Sinensky, Michael
Publikováno v:
ETSU Faculty Works.
Externí odkaz:
https://dc.etsu.edu/etsu-works/18895
Autor:
Liu, June, Thewke, Douglas P., Su, Yan Ru, Linton, MacRae F., Fazio, Sergio, Sinensky, Michael S.
Publikováno v:
ETSU Faculty Works.
Objective - The majority of apoptotic cells in atherosclerotic lesions are macrophages. However, the pathogenic role of macrophage apoptosis in the development of atherosclerosis remains unclear. Elevated expression of Bax, one of the pivotal proapop
Externí odkaz:
https://dc.etsu.edu/etsu-works/18469