Výsledky vyhledávání - "Sinem Milanos"

Akademický článek

Metabolic Products of Linalool and Modulation of GABAA Receptors

Autor: Sinem Milanos, Shaimaa A. Elsharif, Dieter Janzen, Andrea Buettner, Carmen Villmann

Publikováno v: Frontiers in Chemistry, Vol 5 (2017)

Terpenoids are major subcomponents in aroma substances which harbor sedative physiological potential. We have demonstrated that various monoterpenoids such as the acyclic linalool enhance GABAergic currents in an allosteric manner in vitro upon overe

Externí odkaz: https://doaj.org/article/3cb2c3e0b00d4a8494774bf88c162f19

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Structural changes at the myrtenol backbone reverse its positive allosteric potential into inhibitory GABAA receptor modulation

Autor: Thomas M. Frimurer, Daniel Gilbert, Dieter Janzen, Carmen Villmann, Manju Sasi, Sinem Milanos, Katharina Kuenzel, Andrea Buettner

Publikováno v: Biological chemistryReferences. 399(6)

GABAA receptors are ligand-gated anion channels that form pentameric arrangements of various subunits. Positive allosteric modulators of GABAA receptors have been reported as being isolated either from plants or synthesized analogs of known GABAA rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce34c93f6d330ca1b66ee09cb20bc047
https://pubmed.ncbi.nlm.nih.gov/29408795

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