Výsledky vyhledávání - "Sinead M. Flannery"

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

Autor: Christina Paulus, Jessica F. Almine, Gillian Dunphy, Andrew G. Bowie, Michael Nevels, Sinead M. Flannery, Leonie Unterholzner, Martin R. Jakobsen, Dympna J. Connolly, Kasper L Jønsson

Publikováno v: Dunphy, G, Flannery, S M, Almine, J F, Connolly, D J, Paulus, C, Jønsson, K L, Jakobsen, M R, Nevels, M M, Bowie, A G & Unterholzner, L 2018, ' Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage ', Molecular Cell, vol. 71, no. 5, pp. 745-760.e5 . https://doi.org/10.1016/j.molcel.2018.07.034
Molecular Cell

Summary DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6795a2e235e6f9e4dee4197c761c1f21
https://pure.au.dk/portal/da/publications/noncanonical-activation-of-the-dna-sensing-adaptor-sting-by-atm-and-ifi16-mediates-nfb-signaling-after-nuclear-dna-damage(d7ae71a7-c1f9-4b6f-aff7-5ad67fff82d9).html

Zobrazit plný text záznamu

Poxviral Protein A52 Stimulates p38 Mitogen-activated Protein Kinase (MAPK) Activation by Causing Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Self-association Leading to Transforming Growth Factor β-activated Kinase 1 (TAK1) Recruitment

Autor: Sebastian Rupp, Andrew G. Bowie, Tara Hurst, Shun-ichiro Oda, Amir R. Khan, Sinead M. Flannery, Julianne Stack, Kiva Brennan

Publikováno v: Journal of Biological Chemistry. 288:33642-33653

Vaccinia virus encodes a number of proteins that inhibit and manipulate innate immune signaling pathways that also have a role in virulence. These include A52, a protein shown to inhibit IL-1- and Toll-like receptor-stimulated NFκB activation, via i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0472c6c59132ecf51f5e4126932eb587
https://doi.org/10.1074/jbc.m113.485490

Zobrazit plný text záznamu

A frequent hypofunctional IRAK2 variant is associated with reduced spontaneous hepatitis C virus clearance

Publikováno v: Hepatology, Vol. 62, No 5 (2015) pp. 1375-1387

UNLABELLED Patients carrying very rare loss-of-function mutations in interleukin-1 receptor-associated kinase 4 (IRAK4), a critical signaling mediator in Toll-like receptor signaling, are severely immunodeficient, highlighting the paramount role of I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1505f54e1137c98b76a1cf0d274fd5c8
https://www.zora.uzh.ch/id/eprint/117853/

Zobrazit plný text záznamu

A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival

Autor: Bénédicte Manoury, Melanie Bevier, Marco Binder, Julie George, Sabine Dickhöfer, Sinead M. Flannery, Marta E. Alarcón-Riquelme, Søren R. Paludan, Joschka Willemsen, Asta Försti, Andriy V. Kubarenko, Tica Pichulik, Alexander N.R. Weber, Andrew G. Bowie, Clemens Schafmayer, Hui Wang, Stefanie Huhn, Jesús Lascorz

Publikováno v: Wang, H, Flannery, S M, Dickhöfer, S, Huhn, S, George, J, Kubarenko, A V, Lascorz, J, Bevier, M, Willemsen, J, Pichulik, T, Schafmayer, C, Binder, M, Manoury, B, Paludan, S R, Alarcon-Riquelme, M, Bowie, A G, Försti, A & Weber, A N R 2014, ' A coding IRAK2 protein variant compromises Toll-like receptor (TLR) signaling and is associated with colorectal cancer survival ', Journal of Biological Chemistry, vol. 289, no. 33, pp. 23123-31 . https://doi.org/10.1074/jbc.M113.492934

Within innate immune signaling pathways, interleukin-1 receptor-associated kinases (IRAKs) fulfill key roles downstream of multiple Toll-like receptors and the interleukin-1 receptor. Although human IRAK4 deficiency was shown to lead to severe immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25279c7a7c11e3b44663b0c54bf8da9d
https://pure.au.dk/portal/da/publications/a-coding-irak2-protein-variant-compromises-tolllike-receptor-tlr-signaling-and-is-associated-with-colorectal-cancer-survival(e35523db-ae46-49f7-a120-038974c9d6c8).html

Zobrazit plný text záznamu

The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling

Autor: Andrew G. Bowie, Sinead M. Flannery

Publikováno v: Biochemical pharmacology. 80(12)

The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways. TLRs are pattern recognition receptors of the innate immune response that are responsible for s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e28ebfdcde8d3ee368809cdf1cf041
https://pubmed.ncbi.nlm.nih.gov/20599782

Zobrazit plný text záznamu

Akademický článek

Prophylactic pegfilgrastim to prevent febrile neutropenia among patients receiving biweekly (Q2W) chemotherapy regimens: a systematic review of efficacy, effectiveness and safety

Autor: Reshma Mahtani, Jeffrey Crawford, Sinéad M. Flannery, Tatiana Lawrence, Jennifer Schenfeld, Prasad L. Gawade

Publikováno v: BMC Cancer, Vol 21, Iss 1, Pp 1-19 (2021)

Abstract Background Pegfilgrastim, a long-acting granulocyte colony-stimulating factor (G-CSF), is commonly used to prevent febrile neutropenia (FN), a potentially life-threatening complication, following myelosuppressive chemotherapy. The FDA label

Externí odkaz: https://doaj.org/article/1b326982c9d54f28ab74259e0e246318

Zobrazit plný text záznamu

Somatic MyD88 mutations and a germline IRAK2 variant contribute to lymphoma by differential effects on NF-κB (INM7P.354)

Autor: Oliver Wolz, Hui Wang, Souhayla El Maadidi, Janett Fischer, Sinead M. Flannery, Sabine Dickhöfer, Katja Butterbach, Alexandra Nieters, Andrew Bowie, Alexander Weber

Publikováno v: The Journal of Immunology. 194:194.11-194.11

Within innate immune signaling pathways, Myeloid differentiation (MyD) 88 and Interleukin-1 receptor associated kinases (IRAKs) fulfill pivotal roles downstream of multiple Toll-like receptors (TLR). Somatic MyD88 mutations in B cells were reported t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::03986f42dd40bad4c3becc752129b324
https://doi.org/10.4049/jimmunol.194.supp.194.11

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání