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Autor:
Daria L. Bancescu, Haiyan Tang, Weimin Zhong, Yan Zhou, Pétur Henry Petersen, Kaiyong Zou, Sinead B. Stewart, Santiago B. Rompani, Joshua B. Atkins
Publikováno v:
Cell. 129(1):163-178
SummaryMammalian neural progenitor cells divide asymmetrically to self-renew and produce a neuron by segregating cytosolic Numb proteins primarily to one daughter cell. Numb signaling specifies progenitor over neuronal fates but, paradoxically, also